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• W1918097712 endingPage "1679" @default.
• W1918097712 startingPage "1673" @default.
• W1918097712 abstract "Chronic infection with hepatitis B viruses (hepadnaviruses) is a major cause of hepatocellular carcinoma (HCC), but the incubation time varies from 1 to 2 years to several decades in different host species infected with indigenous viruses. To discern the influence of viral and host factors on the kinetics of induction of HCC, we exploited the recent observation that ground squirrel hepatitis virus (GSHV) is infectious in woodchucks (C. Seeger, P. L. Marion, D. Ganem, and H. E. Varmus, J. Virol. 61:3241-3247, 1987) to compare the pathogenic potential of GSHV and woodchuck hepatitis virus (WHV) in chronically infected woodchucks. Chronic GSHV infection in woodchucks produces mild to moderate portal hepatitis, similar to that observed in woodchucks chronically infected with WHV. However, HCC developed in GSHV carriers about 18 months later than in WHV carriers. Thus, although both viruses are oncogenic in woodchucks, GSHV and WHV differ in oncogenic determinants that can affect the kinetics of appearance of HCC in chronically infected animals." @default.
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• W1918097712 date "1991-04-01" @default.
• W1918097712 modified "2023-10-12" @default.
• W1918097712 title "Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host" @default.
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• W1918097712 doi "https://doi.org/10.1128/jvi.65.4.1673-1679.1991" @default.
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