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- W1918223485 abstract "Aim: The aim of this study was to investigate the prevalence and the mechanisms of carbapenem and colistin resistance in Acinetobacter baumannii clinical isolates in an Algerian hospital. Results: Twelve isolates were collected between October 2013 and March 2014. All isolates were resistant to almost all antibiotics tested with a high-level resistance to imipenem (minimum inhibitory concentrations [MICs] >32 mg/L) with one strain showing resistance to colistin (MIC=16 mg/L). The results of the modified Hodge test and the modified Carba NP test were positive for all isolates. Besides, the activity of β-lactamases was inhibited by EDTA in only two isolates. All the 12 isolates contained the naturally occurring blaOXA-51-like gene. Ten of them harbored the OXA β-lactamases: blaOXA-23 (six isolates) and blaOXA-24 (four isolates) genes, while two isolates were positive for blaNDM-1 gene. The colistin-resistant isolate producing OXA-24 enzyme harbored a single mutation in the pmrB gene. Multilocus sequence typing demonstrated that the 12 isolates belonged to 2 clones: 10 to ST2 and 2 to ST85. Conclusions: Here, we describe the mechanisms of carbapenem resistance and we report the first colistin and carbapenemase-producing A. baumannii clinical isolate from a patient in Algeria." @default.
- W1918223485 created "2016-06-24" @default.
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- W1918223485 date "2015-06-01" @default.
- W1918223485 modified "2023-10-18" @default.
- W1918223485 title "Emergence of Colistin- and Carbapenem-Resistant <i>Acinetobacter baumannii</i> ST2 Clinical Isolate in Algeria: First Case Report" @default.
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- W1918223485 doi "https://doi.org/10.1089/mdr.2014.0214" @default.
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