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- W1918281504 abstract "Metastatic dissemination is the leading cause of death in cancer patients, which is particularly evident for high-risk sarcomas such as Ewing sarcoma, osteosarcoma, and rhabdomyosarcoma. Previous research identified a crucial role for YB-1 in the epithelial-to-mesenchymal transition (EMT) and metastasis of epithelial malignancies. Based on clinical data and two distinct animal models, we now report that YB-1 is also a major metastatic driver in high-risk sarcomas. Our data establish YB-1 as a critical regulator of hypoxia-inducible factor 1α (HIF1α) expression in sarcoma cells. YB-1 enhances HIF1α protein expression by directly binding to and activating translation of HIF1A messages. This leads to HIF1α-mediated sarcoma cell invasion and enhanced metastatic capacity in vivo, highlighting a translationally regulated YB-1-HIF1α axis in sarcoma metastasis." @default.
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- W1918281504 date "2015-05-01" @default.
- W1918281504 modified "2023-10-16" @default.
- W1918281504 title "Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis" @default.
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- W1918281504 doi "https://doi.org/10.1016/j.ccell.2015.04.003" @default.
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