FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1918366368> ?p ?o ?g. }

• W1918366368 endingPage "250" @default.
• W1918366368 startingPage "235" @default.
• W1918366368 abstract "ABSTRACT Experiments were performed invitro specifically to elucidate the underlying mechanism(s) of the attenuated adrenergic responses of eel (Anguillarostrata) erythrocytes. This was achieved by comparing β-adrenoceptor numbers and affinities in addition to (i) Na+/H+ exchange activity, (ii) cell swelling and (iii) cyclic AMP formation mediated by catecholamines in eel and trout (Oncorhynchusmykiss) erythrocytes under normoxic and hypoxic conditions. Under normoxic conditions, eel erythrocytes displayed a total absence of Na+/H+ exchange activity (as determined from measurements of extracellular pH) after addition of noradrenaline (50–1000 nmol l− 1) in contrast to a pronounced dose-dependent response in trout. Incubation of the blood under hypoxic conditions, to achieve approximately 50% haemoglobin O2-saturation, further increased the extent of Na+/H+ exchange activation in trout and elicited a statistically significant, although physiologically small (10% of the response in trout), activation of H+ extrusion activity in eel. Catecholamine-mediated cell swelling, although obvious in trout, was absent in eel when estimated under hypoxic conditions. Eel erythrocytes possessed approximately 50% fewer surface β-adrenoceptors than did trout erythrocytes, although the dissociation constants (KD) of these receptors did not differ between eel and trout. The numbers and affinities of the erythrocyte β-adrenoceptors were not significantly affected by the hypoxic incubation. Both eel and trout erythrocytes displayed a dose-dependent elevation of cyclic AMP concentration in response to noradrenaline that was further increased by hypoxia. Surprisingly, eel erythrocytes produced larger quantities of cyclic AMP despite the lower numbers of surface ^adrenoceptors. Thus, the absence of adrenergic swelling and the attenuated H+ extrusion response in eel erythrocytes cannot be attributed to insufficient numbers of β-adrenoceptors or to functional uncoupling of these receptors from adenylate cyclase. Instead, the differences between trout and eel may reflect differing numbers of Na+/H+ exchangers or fundamental differences in the manner by which these exchangers are activated by cyclic AMP." @default.
• W1918366368 created "2016-06-24" @default.
• W1918366368 creator A5028844049 @default.
• W1918366368 creator A5085589370 @default.
• W1918366368 date "1992-06-01" @default.
• W1918366368 modified "2023-10-18" @default.
• W1918366368 title "The Relationship Between <i>β</i>-Adrenoceptors and Adrenergic Responsiveness in Trout (<i>Oncorhynchus Mykiss</i>) and Eel (<i>Anguilla Rostrata</i>) Erythrocytes" @default.
• W1918366368 cites W183751255 @default.
• W1918366368 cites W1877513091 @default.
• W1918366368 cites W1900311455 @default.
• W1918366368 cites W1903585685 @default.
• W1918366368 cites W1922081365 @default.
• W1918366368 cites W1928903987 @default.
• W1918366368 cites W1968728965 @default.
• W1918366368 cites W1974164203 @default.
• W1918366368 cites W1981780789 @default.
• W1918366368 cites W1983649348 @default.
• W1918366368 cites W1990783328 @default.
• W1918366368 cites W1998667416 @default.
• W1918366368 cites W1999962748 @default.
• W1918366368 cites W2005961424 @default.
• W1918366368 cites W2006536617 @default.
• W1918366368 cites W2015274981 @default.
• W1918366368 cites W2020641095 @default.
• W1918366368 cites W2023689262 @default.
• W1918366368 cites W2028695056 @default.
• W1918366368 cites W2031893631 @default.
• W1918366368 cites W2034125793 @default.
• W1918366368 cites W2035634305 @default.
• W1918366368 cites W2035663578 @default.
• W1918366368 cites W2035820431 @default.
• W1918366368 cites W2042244484 @default.
• W1918366368 cites W2049741377 @default.
• W1918366368 cites W2065613764 @default.
• W1918366368 cites W2074862730 @default.
• W1918366368 cites W2082481253 @default.
• W1918366368 cites W2107348469 @default.
• W1918366368 cites W2112620534 @default.
• W1918366368 cites W2113034726 @default.
• W1918366368 cites W2124183721 @default.
• W1918366368 cites W2136835253 @default.
• W1918366368 cites W2140886961 @default.
• W1918366368 cites W2148431088 @default.
• W1918366368 cites W2161411881 @default.
• W1918366368 cites W2184645745 @default.
• W1918366368 cites W2186770200 @default.
• W1918366368 cites W2189238283 @default.
• W1918366368 cites W2253247090 @default.
• W1918366368 cites W2278302492 @default.
• W1918366368 cites W2318121197 @default.
• W1918366368 cites W2344763969 @default.
• W1918366368 cites W2345392007 @default.
• W1918366368 cites W2347084966 @default.
• W1918366368 cites W2416829621 @default.
• W1918366368 doi "https://doi.org/10.1242/jeb.167.1.235" @default.
• W1918366368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1321872" @default.
• W1918366368 hasPublicationYear "1992" @default.
• W1918366368 type Work @default.
• W1918366368 sameAs 1918366368 @default.
• W1918366368 citedByCount "34" @default.
• W1918366368 countsByYear W19183663682013 @default.
• W1918366368 countsByYear W19183663682017 @default.
• W1918366368 crossrefType "journal-article" @default.
• W1918366368 hasAuthorship W1918366368A5028844049 @default.
• W1918366368 hasAuthorship W1918366368A5085589370 @default.
• W1918366368 hasConcept C126322002 @default.
• W1918366368 hasConcept C134018914 @default.
• W1918366368 hasConcept C185592680 @default.
• W1918366368 hasConcept C25642318 @default.
• W1918366368 hasConcept C2775894120 @default.
• W1918366368 hasConcept C2777292126 @default.
• W1918366368 hasConcept C2779363728 @default.
• W1918366368 hasConcept C2779409272 @default.
• W1918366368 hasConcept C2909208804 @default.
• W1918366368 hasConcept C2909653074 @default.
• W1918366368 hasConcept C2994167347 @default.
• W1918366368 hasConcept C505870484 @default.
• W1918366368 hasConcept C55493867 @default.
• W1918366368 hasConcept C59822182 @default.
• W1918366368 hasConcept C71924100 @default.
• W1918366368 hasConcept C86803240 @default.
• W1918366368 hasConceptScore W1918366368C126322002 @default.
• W1918366368 hasConceptScore W1918366368C134018914 @default.
• W1918366368 hasConceptScore W1918366368C185592680 @default.
• W1918366368 hasConceptScore W1918366368C25642318 @default.
• W1918366368 hasConceptScore W1918366368C2775894120 @default.
• W1918366368 hasConceptScore W1918366368C2777292126 @default.
• W1918366368 hasConceptScore W1918366368C2779363728 @default.
• W1918366368 hasConceptScore W1918366368C2779409272 @default.
• W1918366368 hasConceptScore W1918366368C2909208804 @default.
• W1918366368 hasConceptScore W1918366368C2909653074 @default.
• W1918366368 hasConceptScore W1918366368C2994167347 @default.
• W1918366368 hasConceptScore W1918366368C505870484 @default.
• W1918366368 hasConceptScore W1918366368C55493867 @default.
• W1918366368 hasConceptScore W1918366368C59822182 @default.
• W1918366368 hasConceptScore W1918366368C71924100 @default.
• W1918366368 hasConceptScore W1918366368C86803240 @default.
• W1918366368 hasIssue "1" @default.

• next