Matches in SemOpenAlex for { <https://semopenalex.org/work/W1918373896> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1918373896 endingPage "2410" @default.
- W1918373896 startingPage "2404" @default.
- W1918373896 abstract "Abstract Very low doses of trypsin (5 micrograms/ml) are sufficient to ablate NK cell activity. This finding was used to make several observations, and we have attempted to relate these observations to specific cell surface macromolecules. First, trypsinized effector cells no longer lysed seven different NK-susceptible targets, but the lysis of three additional targets was unaffected. These results suggest a heterogeneity of recognition potential that is inconsistent with the notion that there is only one class of NK receptors and one class of target structures. Trypsin does not affect the conjugation of effector and target cells. Secondly, we have tried to identify those cell surface molecules that are affected by this low dose of enzyme. The examination of the 125I-labeled glycoprotein fraction NK-enriched cells showed that at least four molecules are cleaved, one of which may be in the T200 family. The examination of the [3H]galactose-labeled cell surface glycoproteins suggested in particular that some high m.w. glycoproteins were affected at the dose of trypsin that ablates NK function. Analysis of those molecules that we previously implicated in NK function, defined by monoclonal antibodies that block NK lysis, allowed us to rule out a role for the Tp 50 and Lp95-150 structures, while providing additional evidence of a role for the T200 glycoproteins in the trypsin-sensitive stage of cytolysis. Finally, closer examination of the electrophoretic mobilities and trypsin sensitivity of the T200 structures on highly enriched NK cells showed these structures to be indistinguishable from the T cell form of T200, yet quite distinct from the monocyte form. These results are therefore consistent with the possibility that NK cells are of the T rather than the monocyte lineage, and furthermore support a role for the T200 structure in the post-binding trypsin-sensitive stage of the NK cytolytic process." @default.
- W1918373896 created "2016-06-24" @default.
- W1918373896 creator A5011371393 @default.
- W1918373896 creator A5047041715 @default.
- W1918373896 creator A5066072289 @default.
- W1918373896 creator A5085800754 @default.
- W1918373896 date "1983-11-01" @default.
- W1918373896 modified "2023-09-26" @default.
- W1918373896 title "T cell nature and heterogeneity of recognition structures of human natural killer (NK) cells." @default.
- W1918373896 doi "https://doi.org/10.4049/jimmunol.131.5.2404" @default.
- W1918373896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6415167" @default.
- W1918373896 hasPublicationYear "1983" @default.
- W1918373896 type Work @default.
- W1918373896 sameAs 1918373896 @default.
- W1918373896 citedByCount "11" @default.
- W1918373896 crossrefType "journal-article" @default.
- W1918373896 hasAuthorship W1918373896A5011371393 @default.
- W1918373896 hasAuthorship W1918373896A5047041715 @default.
- W1918373896 hasAuthorship W1918373896A5066072289 @default.
- W1918373896 hasAuthorship W1918373896A5085800754 @default.
- W1918373896 hasBestOaLocation W19183738961 @default.
- W1918373896 hasConcept C108625454 @default.
- W1918373896 hasConcept C109316439 @default.
- W1918373896 hasConcept C1491633281 @default.
- W1918373896 hasConcept C153911025 @default.
- W1918373896 hasConcept C159654299 @default.
- W1918373896 hasConcept C181199279 @default.
- W1918373896 hasConcept C202751555 @default.
- W1918373896 hasConcept C203014093 @default.
- W1918373896 hasConcept C2778102761 @default.
- W1918373896 hasConcept C2780340462 @default.
- W1918373896 hasConcept C38240268 @default.
- W1918373896 hasConcept C51785407 @default.
- W1918373896 hasConcept C542903549 @default.
- W1918373896 hasConcept C55493867 @default.
- W1918373896 hasConcept C57409179 @default.
- W1918373896 hasConcept C73588182 @default.
- W1918373896 hasConcept C86803240 @default.
- W1918373896 hasConcept C95444343 @default.
- W1918373896 hasConceptScore W1918373896C108625454 @default.
- W1918373896 hasConceptScore W1918373896C109316439 @default.
- W1918373896 hasConceptScore W1918373896C1491633281 @default.
- W1918373896 hasConceptScore W1918373896C153911025 @default.
- W1918373896 hasConceptScore W1918373896C159654299 @default.
- W1918373896 hasConceptScore W1918373896C181199279 @default.
- W1918373896 hasConceptScore W1918373896C202751555 @default.
- W1918373896 hasConceptScore W1918373896C203014093 @default.
- W1918373896 hasConceptScore W1918373896C2778102761 @default.
- W1918373896 hasConceptScore W1918373896C2780340462 @default.
- W1918373896 hasConceptScore W1918373896C38240268 @default.
- W1918373896 hasConceptScore W1918373896C51785407 @default.
- W1918373896 hasConceptScore W1918373896C542903549 @default.
- W1918373896 hasConceptScore W1918373896C55493867 @default.
- W1918373896 hasConceptScore W1918373896C57409179 @default.
- W1918373896 hasConceptScore W1918373896C73588182 @default.
- W1918373896 hasConceptScore W1918373896C86803240 @default.
- W1918373896 hasConceptScore W1918373896C95444343 @default.
- W1918373896 hasIssue "5" @default.
- W1918373896 hasLocation W19183738961 @default.
- W1918373896 hasLocation W19183738962 @default.
- W1918373896 hasOpenAccess W1918373896 @default.
- W1918373896 hasPrimaryLocation W19183738961 @default.
- W1918373896 hasRelatedWork W112407786 @default.
- W1918373896 hasRelatedWork W1598469433 @default.
- W1918373896 hasRelatedWork W1918373896 @default.
- W1918373896 hasRelatedWork W1987217913 @default.
- W1918373896 hasRelatedWork W2065973567 @default.
- W1918373896 hasRelatedWork W2074989987 @default.
- W1918373896 hasRelatedWork W2394608364 @default.
- W1918373896 hasRelatedWork W2423556703 @default.
- W1918373896 hasRelatedWork W248869965 @default.
- W1918373896 hasRelatedWork W8014264 @default.
- W1918373896 hasVolume "131" @default.
- W1918373896 isParatext "false" @default.
- W1918373896 isRetracted "false" @default.
- W1918373896 magId "1918373896" @default.
- W1918373896 workType "article" @default.