FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1918394768> ?p ?o ?g. }

• W1918394768 abstract "Most biological processes are influenced by protein post-translational modifications (PTMs). Identifying novel PTM sites in different organisms, including humans and model organisms, has expedited our understanding of key signal transduction mechanisms. However, with increasing availability of deep, quantitative datasets in diverse species, there is a growing need for tools to facilitate cross-species comparison of PTM data. This is particularly important because functionally important modification sites are more likely to be evolutionarily conserved; yet cross-species comparison of PTMs is difficult since they often lie in structurally disordered protein domains. Current tools that address this can only map known PTMs between species based on known orthologous phosphosites, and do not enable the cross-species mapping of newly identified modification sites. Here, we addressed this by developing a web-based software tool, PhosphOrtholog ( www.phosphortholog.com ) that accurately maps protein modification sites between different species. This facilitates the comparison of datasets derived from multiple species, and should be a valuable tool for the proteomics community.Here we describe PhosphOrtholog, a web-based application for mapping known and novel orthologous PTM sites from experimental data obtained from different species. PhosphOrtholog is the only generic and automated tool that enables cross-species comparison of large-scale PTM datasets without relying on existing PTM databases. This is achieved through pairwise sequence alignment of orthologous protein residues. To demonstrate its utility we apply it to two sets of human and rat muscle phosphoproteomes generated following insulin and exercise stimulation, respectively, and one publicly available mouse phosphoproteome following cellular stress revealing high mapping and coverage efficiency. Although coverage statistics are dataset dependent, PhosphOrtholog increased the number of cross-species mapped sites in all our example data sets by more than double when compared to those recovered using existing resources such as PhosphoSitePlus.PhosphOrtholog is the first tool that enables mapping of thousands of novel and known protein phosphorylation sites across species, accessible through an easy-to-use web interface. Identification of conserved PTMs across species from large-scale experimental data increases our knowledgebase of functional PTM sites. Moreover, PhosphOrtholog is generic being applicable to other PTM datasets such as acetylation, ubiquitination and methylation." @default.
• W1918394768 created "2016-06-24" @default.
• W1918394768 creator A5009513439 @default.
• W1918394768 creator A5014643889 @default.
• W1918394768 creator A5026046629 @default.
• W1918394768 creator A5028524705 @default.
• W1918394768 creator A5051169332 @default.
• W1918394768 creator A5060826983 @default.
• W1918394768 creator A5062542643 @default.
• W1918394768 creator A5067195415 @default.
• W1918394768 creator A5083700249 @default.
• W1918394768 date "2015-08-19" @default.
• W1918394768 modified "2023-10-09" @default.
• W1918394768 title "PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications" @default.
• W1918394768 cites W1981593008 @default.
• W1918394768 cites W1993450321 @default.
• W1918394768 cites W1996310767 @default.
• W1918394768 cites W1997113958 @default.
• W1918394768 cites W2026465178 @default.
• W1918394768 cites W2030205108 @default.
• W1918394768 cites W2036321220 @default.
• W1918394768 cites W2043274355 @default.
• W1918394768 cites W2045949302 @default.
• W1918394768 cites W2049349724 @default.
• W1918394768 cites W2054100836 @default.
• W1918394768 cites W2066593167 @default.
• W1918394768 cites W2078964925 @default.
• W1918394768 cites W2080752012 @default.
• W1918394768 cites W2089367187 @default.
• W1918394768 cites W2096525273 @default.
• W1918394768 cites W2101771026 @default.
• W1918394768 cites W2103174201 @default.
• W1918394768 cites W2104496885 @default.
• W1918394768 cites W2104726963 @default.
• W1918394768 cites W2105039688 @default.
• W1918394768 cites W2106446195 @default.
• W1918394768 cites W2123527017 @default.
• W1918394768 cites W2129913176 @default.
• W1918394768 cites W2130222062 @default.
• W1918394768 cites W2130253098 @default.
• W1918394768 cites W2130614771 @default.
• W1918394768 cites W2134038772 @default.
• W1918394768 cites W2136167599 @default.
• W1918394768 cites W2140946052 @default.
• W1918394768 cites W2141708714 @default.
• W1918394768 cites W2143210482 @default.
• W1918394768 cites W2145825942 @default.
• W1918394768 cites W2150271494 @default.
• W1918394768 cites W2154846744 @default.
• W1918394768 cites W2155521690 @default.
• W1918394768 cites W2155814768 @default.
• W1918394768 cites W2157658519 @default.
• W1918394768 cites W2157918066 @default.
• W1918394768 cites W2167188257 @default.
• W1918394768 cites W2167350014 @default.
• W1918394768 cites W2325375737 @default.
• W1918394768 cites W2605068739 @default.
• W1918394768 cites W4231621646 @default.
• W1918394768 cites W4242739003 @default.
• W1918394768 doi "https://doi.org/10.1186/s12864-015-1820-x" @default.
• W1918394768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4539857" @default.
• W1918394768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26283093" @default.
• W1918394768 hasPublicationYear "2015" @default.
• W1918394768 type Work @default.
• W1918394768 sameAs 1918394768 @default.
• W1918394768 citedByCount "19" @default.
• W1918394768 countsByYear W19183947682015 @default.
• W1918394768 countsByYear W19183947682016 @default.
• W1918394768 countsByYear W19183947682017 @default.
• W1918394768 countsByYear W19183947682019 @default.
• W1918394768 countsByYear W19183947682021 @default.
• W1918394768 countsByYear W19183947682022 @default.
• W1918394768 countsByYear W19183947682023 @default.
• W1918394768 crossrefType "journal-article" @default.
• W1918394768 hasAuthorship W1918394768A5009513439 @default.
• W1918394768 hasAuthorship W1918394768A5014643889 @default.
• W1918394768 hasAuthorship W1918394768A5026046629 @default.
• W1918394768 hasAuthorship W1918394768A5028524705 @default.
• W1918394768 hasAuthorship W1918394768A5051169332 @default.
• W1918394768 hasAuthorship W1918394768A5060826983 @default.
• W1918394768 hasAuthorship W1918394768A5062542643 @default.
• W1918394768 hasAuthorship W1918394768A5067195415 @default.
• W1918394768 hasAuthorship W1918394768A5083700249 @default.
• W1918394768 hasBestOaLocation W19183947681 @default.
• W1918394768 hasConcept C100631289 @default.
• W1918394768 hasConcept C104317684 @default.
• W1918394768 hasConcept C150194340 @default.
• W1918394768 hasConcept C154945302 @default.
• W1918394768 hasConcept C181199279 @default.
• W1918394768 hasConcept C184898388 @default.
• W1918394768 hasConcept C19843653 @default.
• W1918394768 hasConcept C41008148 @default.
• W1918394768 hasConcept C46111723 @default.
• W1918394768 hasConcept C54355233 @default.
• W1918394768 hasConcept C55493867 @default.
• W1918394768 hasConcept C70721500 @default.
• W1918394768 hasConcept C86803240 @default.
• W1918394768 hasConcept C95371953 @default.
• W1918394768 hasConceptScore W1918394768C100631289 @default.
• W1918394768 hasConceptScore W1918394768C104317684 @default.

• next