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- W191840116 abstract "Lilienfeld & Parkhurst [1] introduced the phrase of reproductive wastage to describe the range of unfavorable outcomes of pregnancy that may follow prenatal or perinatal insult. In teratological research, this continuum is divided into four broad classes of outcome: embryoor fetolethality, structural malformation, growth retardation, and functional deficit [2]. In general, the specific manner in which the toxicity of a substance is expressed depends on both the dosage and the stage of development of the fetus at the time of exposure. Drawing on animal models, Rodier [3] identified patterns in the relationship between stage of neurogenesis at the time of insult and the resulting morphologic and, in some cases, behavioral deficits. Functional deficits, the province of behavioral teratology, include impairment of an organism's adaptive capacities in the absence of identifiable morphologic defect. These deficits are generally thought to be mediated by disruptions of biochemical pathways rather than by cell death or gross alterations in patterns of cell proliferation, migration, or differentiation [4]. Investigators are currently engaged in largely descriptive studies of the behavioral correlates of exposure to selected agents; efforts to explore their neurochemical underpinnings have been limited mostly to catecholaminergic systems (e.g., [5,6]). An agent that produces central nervous system (CNS) malformation at high doses generally produces behavioral effects at lower doses" @default.
- W191840116 created "2016-06-24" @default.
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- W191840116 date "1985-09-01" @default.
- W191840116 modified "2023-09-23" @default.
- W191840116 title "Prenatal and Early Postnatal Exposure to Lead: Developmental Effects, Correlates, and Implications" @default.
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- W191840116 doi "https://doi.org/10.1080/00207411.1985.11449004" @default.
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