Matches in SemOpenAlex for { <https://semopenalex.org/work/W1918462035> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1918462035 endingPage "1217" @default.
- W1918462035 startingPage "1212" @default.
- W1918462035 abstract "Available evidence indicates that some Tie2-expressing (Tie2+) cells serve as multipotent progenitors that have robust BMP-dependent osteogenic activity and mediate heterotopic ossification (HO). Since signaling through the G protein Gi is required for cell motility, we hypothesized that blockade of endogenous Gi signaling in Tie2+ cell populations would prevent HO formation. Blockade of Gi signaling in Tie2+ cells was accomplished in transgenic mice with expression of pertussis toxin (PTX) under the control of the Tie2 promoter (Tie2+/PTX+). Bone formation within HOs was evaluated 2 weeks after BMP injection. Expression of PTX in Tie2+ cells significantly reduced the bone volume (BV) of HOs in male and female mice. Orthotopic bones were assessed at the distal femur and expression of PTX significantly increased trabecular bone fractional volume and bone formation rate in females only. In adult Tie2+/GFP+ mice, GFP+ cells appeared both inside and at the surfaces of bone tissue within HOs and in orthotopic bones. In summary, blockade of Gi signaling in Tie2+ cells reduced the accrual of HOs and stimulated osteogenesis in orthotopic bones. Targeting of Gi protein coupled receptors in Tie2+ cells may be a novel therapeutic strategy in states of abnormal bone formation such as osteoporosis and HO. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1212–1217, 2015." @default.
- W1918462035 created "2016-06-24" @default.
- W1918462035 creator A5005947206 @default.
- W1918462035 creator A5031783487 @default.
- W1918462035 creator A5052787170 @default.
- W1918462035 creator A5062591890 @default.
- W1918462035 creator A5067422009 @default.
- W1918462035 creator A5077593954 @default.
- W1918462035 creator A5002157913 @default.
- W1918462035 date "2015-05-20" @default.
- W1918462035 modified "2023-10-16" @default.
- W1918462035 title "Effects of blockade of endogenous Gisignaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification" @default.
- W1918462035 cites W1578388451 @default.
- W1918462035 cites W1964059429 @default.
- W1918462035 cites W1974137634 @default.
- W1918462035 cites W1976084770 @default.
- W1918462035 cites W1988654486 @default.
- W1918462035 cites W2006851924 @default.
- W1918462035 cites W2007940290 @default.
- W1918462035 cites W2025138809 @default.
- W1918462035 cites W2040203747 @default.
- W1918462035 cites W2044220763 @default.
- W1918462035 cites W2051538934 @default.
- W1918462035 cites W2056142105 @default.
- W1918462035 cites W2063445980 @default.
- W1918462035 cites W2064302505 @default.
- W1918462035 cites W2074994056 @default.
- W1918462035 cites W2082319740 @default.
- W1918462035 cites W2082397866 @default.
- W1918462035 cites W2086397585 @default.
- W1918462035 cites W2113679184 @default.
- W1918462035 cites W2136480937 @default.
- W1918462035 cites W2164703635 @default.
- W1918462035 cites W2189378924 @default.
- W1918462035 cites W4248259718 @default.
- W1918462035 cites W4253100502 @default.
- W1918462035 doi "https://doi.org/10.1002/jor.22876" @default.
- W1918462035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25773760" @default.
- W1918462035 hasPublicationYear "2015" @default.
- W1918462035 type Work @default.
- W1918462035 sameAs 1918462035 @default.
- W1918462035 citedByCount "2" @default.
- W1918462035 countsByYear W19184620352016 @default.
- W1918462035 countsByYear W19184620352020 @default.
- W1918462035 crossrefType "journal-article" @default.
- W1918462035 hasAuthorship W1918462035A5002157913 @default.
- W1918462035 hasAuthorship W1918462035A5005947206 @default.
- W1918462035 hasAuthorship W1918462035A5031783487 @default.
- W1918462035 hasAuthorship W1918462035A5052787170 @default.
- W1918462035 hasAuthorship W1918462035A5062591890 @default.
- W1918462035 hasAuthorship W1918462035A5067422009 @default.
- W1918462035 hasAuthorship W1918462035A5077593954 @default.
- W1918462035 hasBestOaLocation W19184620351 @default.
- W1918462035 hasConcept C105702510 @default.
- W1918462035 hasConcept C126322002 @default.
- W1918462035 hasConcept C170493617 @default.
- W1918462035 hasConcept C201750760 @default.
- W1918462035 hasConcept C2778468042 @default.
- W1918462035 hasConcept C2778842504 @default.
- W1918462035 hasConcept C2780650075 @default.
- W1918462035 hasConcept C28328180 @default.
- W1918462035 hasConcept C71924100 @default.
- W1918462035 hasConcept C85219853 @default.
- W1918462035 hasConcept C86803240 @default.
- W1918462035 hasConcept C95444343 @default.
- W1918462035 hasConceptScore W1918462035C105702510 @default.
- W1918462035 hasConceptScore W1918462035C126322002 @default.
- W1918462035 hasConceptScore W1918462035C170493617 @default.
- W1918462035 hasConceptScore W1918462035C201750760 @default.
- W1918462035 hasConceptScore W1918462035C2778468042 @default.
- W1918462035 hasConceptScore W1918462035C2778842504 @default.
- W1918462035 hasConceptScore W1918462035C2780650075 @default.
- W1918462035 hasConceptScore W1918462035C28328180 @default.
- W1918462035 hasConceptScore W1918462035C71924100 @default.
- W1918462035 hasConceptScore W1918462035C85219853 @default.
- W1918462035 hasConceptScore W1918462035C86803240 @default.
- W1918462035 hasConceptScore W1918462035C95444343 @default.
- W1918462035 hasFunder F4320338280 @default.
- W1918462035 hasIssue "8" @default.
- W1918462035 hasLocation W19184620351 @default.
- W1918462035 hasLocation W19184620352 @default.
- W1918462035 hasOpenAccess W1918462035 @default.
- W1918462035 hasPrimaryLocation W19184620351 @default.
- W1918462035 hasRelatedWork W1990270102 @default.
- W1918462035 hasRelatedWork W2007160459 @default.
- W1918462035 hasRelatedWork W2008518697 @default.
- W1918462035 hasRelatedWork W2017687754 @default.
- W1918462035 hasRelatedWork W2086284917 @default.
- W1918462035 hasRelatedWork W2092058327 @default.
- W1918462035 hasRelatedWork W2409420033 @default.
- W1918462035 hasRelatedWork W2748683936 @default.
- W1918462035 hasRelatedWork W3013936228 @default.
- W1918462035 hasRelatedWork W3031339473 @default.
- W1918462035 hasVolume "33" @default.
- W1918462035 isParatext "false" @default.
- W1918462035 isRetracted "false" @default.
- W1918462035 magId "1918462035" @default.
- W1918462035 workType "article" @default.