FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1918492041> ?p ?o ?g. }

• W1918492041 endingPage "977" @default.
• W1918492041 startingPage "964" @default.
• W1918492041 abstract "Chlamydia trachomatis acquires C6-NBD-sphingomyelin endogenously synthesized from C6-NBD-ceramide and transported to the vesicle (inclusion) in which they multiply. Here we explore the mechanisms of this unusual trafficking and further characterize the association of the chlamydial inclusion with the Golgi apparatus. Endocytosed chlamydiae are trafficked to the Golgi region and begin to acquire sphingolipids from the host within a few hours following infection. The transport of NBD-sphingolipid to the inclusion is energy- and temperature-dependent with the characteristics of an active, vesicle-mediated process. Photo-oxidation of C5-DMB-ceramide, in the presence of diaminobenzidine, identified DMB-lipids in vesicles in the process of fusing to the chlamydial inclusion membrane. C6-NBD-sphingomyelin incorporated into the plasma membrane is not trafficked to the inclusion to a significant degree, suggesting the pathway for sphingomyelin trafficking is direct from the Golgi apparatus to the chlamydial inclusion. Lectins and antibody probes for Golgi-specific glycoproteins demonstrate the close association of the chlamydial inclusion with the Golgi apparatus but do not detect these markers in the inclusion membrane. Collectively, the data are consistent with a model in which C.trachomatis inhabits a unique vesicle which interrupts an exocytic pathway to intercept host sphingolipids in transit from the Golgi apparatus to the plasma membrane." @default.
• W1918492041 created "2016-06-24" @default.
• W1918492041 creator A5050772644 @default.
• W1918492041 creator A5051283258 @default.
• W1918492041 creator A5081751244 @default.
• W1918492041 creator A5089751989 @default.
• W1918492041 date "1996-03-01" @default.
• W1918492041 modified "2023-10-13" @default.
• W1918492041 title "Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane." @default.
• W1918492041 cites W1518225155 @default.
• W1918492041 cites W1633066991 @default.
• W1918492041 cites W1778011655 @default.
• W1918492041 cites W1890701869 @default.
• W1918492041 cites W1892644136 @default.
• W1918492041 cites W1967145791 @default.
• W1918492041 cites W1968102552 @default.
• W1918492041 cites W1985947029 @default.
• W1918492041 cites W1989290448 @default.
• W1918492041 cites W2027899810 @default.
• W1918492041 cites W2028983576 @default.
• W1918492041 cites W2034863466 @default.
• W1918492041 cites W2036174328 @default.
• W1918492041 cites W2059428912 @default.
• W1918492041 cites W2059526131 @default.
• W1918492041 cites W2064568131 @default.
• W1918492041 cites W2065983399 @default.
• W1918492041 cites W2076889165 @default.
• W1918492041 cites W2079407464 @default.
• W1918492041 cites W2085364060 @default.
• W1918492041 cites W2087053044 @default.
• W1918492041 cites W2111930154 @default.
• W1918492041 cites W2114346833 @default.
• W1918492041 cites W2129551826 @default.
• W1918492041 cites W2130452852 @default.
• W1918492041 cites W2131115067 @default.
• W1918492041 cites W2136287791 @default.
• W1918492041 cites W2147251439 @default.
• W1918492041 cites W2152708819 @default.
• W1918492041 cites W2160685946 @default.
• W1918492041 cites W2165296438 @default.
• W1918492041 cites W2168591865 @default.
• W1918492041 cites W2177567467 @default.
• W1918492041 cites W2417325128 @default.
• W1918492041 doi "https://doi.org/10.1002/j.1460-2075.1996.tb00433.x" @default.
• W1918492041 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/449991" @default.
• W1918492041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8605892" @default.
• W1918492041 hasPublicationYear "1996" @default.
• W1918492041 type Work @default.
• W1918492041 sameAs 1918492041 @default.
• W1918492041 citedByCount "369" @default.
• W1918492041 countsByYear W19184920412012 @default.
• W1918492041 countsByYear W19184920412013 @default.
• W1918492041 countsByYear W19184920412014 @default.
• W1918492041 countsByYear W19184920412015 @default.
• W1918492041 countsByYear W19184920412016 @default.
• W1918492041 countsByYear W19184920412017 @default.
• W1918492041 countsByYear W19184920412018 @default.
• W1918492041 countsByYear W19184920412019 @default.
• W1918492041 countsByYear W19184920412020 @default.
• W1918492041 countsByYear W19184920412021 @default.
• W1918492041 countsByYear W19184920412022 @default.
• W1918492041 countsByYear W19184920412023 @default.
• W1918492041 crossrefType "journal-article" @default.
• W1918492041 hasAuthorship W1918492041A5050772644 @default.
• W1918492041 hasAuthorship W1918492041A5051283258 @default.
• W1918492041 hasAuthorship W1918492041A5081751244 @default.
• W1918492041 hasAuthorship W1918492041A5089751989 @default.
• W1918492041 hasBestOaLocation W19184920411 @default.
• W1918492041 hasConcept C119062480 @default.
• W1918492041 hasConcept C130316041 @default.
• W1918492041 hasConcept C158617107 @default.
• W1918492041 hasConcept C159047783 @default.
• W1918492041 hasConcept C190283241 @default.
• W1918492041 hasConcept C2777391075 @default.
• W1918492041 hasConcept C2777851122 @default.
• W1918492041 hasConcept C41625074 @default.
• W1918492041 hasConcept C55493867 @default.
• W1918492041 hasConcept C61322309 @default.
• W1918492041 hasConcept C61705674 @default.
• W1918492041 hasConcept C62478195 @default.
• W1918492041 hasConcept C79266657 @default.
• W1918492041 hasConcept C86803240 @default.
• W1918492041 hasConcept C95444343 @default.
• W1918492041 hasConceptScore W1918492041C119062480 @default.
• W1918492041 hasConceptScore W1918492041C130316041 @default.
• W1918492041 hasConceptScore W1918492041C158617107 @default.
• W1918492041 hasConceptScore W1918492041C159047783 @default.
• W1918492041 hasConceptScore W1918492041C190283241 @default.
• W1918492041 hasConceptScore W1918492041C2777391075 @default.
• W1918492041 hasConceptScore W1918492041C2777851122 @default.
• W1918492041 hasConceptScore W1918492041C41625074 @default.
• W1918492041 hasConceptScore W1918492041C55493867 @default.
• W1918492041 hasConceptScore W1918492041C61322309 @default.
• W1918492041 hasConceptScore W1918492041C61705674 @default.
• W1918492041 hasConceptScore W1918492041C62478195 @default.
• W1918492041 hasConceptScore W1918492041C79266657 @default.
• W1918492041 hasConceptScore W1918492041C86803240 @default.
• W1918492041 hasConceptScore W1918492041C95444343 @default.

• next