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- W191853723 abstract "We examined the effect of skeletal muscle immobilization in either stretched or shortened positions on cell cycle control genes. Female rats (250-275g) were assigned to one of three experimental groups: control (CON, n=10); 90 degree (90DEG, n=10, shortened muscle length); or dorsiflexion (DORS, n=10, stretched muscle length). CON animals were allowed normal mobility while 90DEG and DORS animals had their ankles bilaterally fixed in neutral and dorsiflexed positions respectively using plaster casts. After three days, six animals in each group were sacrificed and soleus (SOL) muscles removed. The remaining four animals in each group had their SOL removed after 14 days. RT was performed on 1μg of purified RNA from each SOL. PCR was performed using commercially available rodent primers. Three day DORS SOL exhibited significantly higher expression of GADD45 alpha, GADD45 beta, MyoD, myogenin, and p21when compared to CON (P<0.05). At the 14 day time point, upregulation of GADD45 alpha, GADD45 beta, MyoD, and p21 was seen in 90DEG SOL compared to CON (P<0.05). Thus, immobilization of skeletal muscle at any length seems to induce upregulation of cell cycle control genes. Supported by NIH AR-46856" @default.
- W191853723 created "2016-06-24" @default.
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- W191853723 date "2006-03-01" @default.
- W191853723 modified "2023-10-03" @default.
- W191853723 title "Effect of immobilization and stretch on skeletal muscle cell cycle control genes" @default.
- W191853723 doi "https://doi.org/10.1096/fasebj.20.4.a391" @default.
- W191853723 hasPublicationYear "2006" @default.
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