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• W1918595551 endingPage "6094" @default.
• W1918595551 startingPage "6088" @default.
• W1918595551 abstract "Killer cell lectin-like receptor G1 (KLRG1) is one of several inhibitory killer cell lectin-like receptors expressed by NK cells and T lymphocytes, mainly CD8(+) effector/memory cells that can secrete cytokines but have poor proliferative capacity. Using multiparameter flow cytometry, we studied KLRG1 expression on CD8(+) T cells specific for epitopes of CMV, EBV, influenza, and HIV. Over 92% of CD8(+) cells specific for CMV or EBV expressed KLRG1 during the latent stage of these chronic infections. CD8(+) T cell cells specific for HIV epitopes were mostly (72-89%) KLRG1(+), even though not quite at the level of predominance noted with CMV or EBV. Lower frequency of KLRG1 expression was observed among CD8(+) cells specific for influenza (40-73%), a resolved infection without a latent stage. We further observed that CD8(+) cells expressing CD57, a marker of replicative senescence, also expressed KLRG1; however, a population of CD57(-)KLRG1(+) cells was also identified. This population may represent a memory phenotype, because they also expressed CD27, CD28, CCR7, and CD127. In contrast, CD57(+)KLRG1(+) cells did not express CD27, CD28, and CCR7, and expressed CD127 at a much lower frequency, indicating that they represent effector cells that are truly terminally differentiated. The combination of KLRG1 and CD57 expression might thus aid in refining functional characterization of CD8(+) T cell subsets." @default.
• W1918595551 created "2016-06-24" @default.
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• W1918595551 date "2005-05-05" @default.
• W1918595551 modified "2023-10-16" @default.
• W1918595551 title "Expression of Killer Cell Lectin-Like Receptor G1 on Antigen-Specific Human CD8⁺ T Lymphocytes during Active, Latent, and Resolved Infection and its Relation with CD57" @default.
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• W1918595551 doi "https://doi.org/10.4049/jimmunol.174.10.6088" @default.
• W1918595551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15879103" @default.
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