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- W1918604927 abstract "The clonal composition of neoplastic foci was examined in histological sections of the colonic epithelium of azoxymethane (CAS: 25843-45-2)-treated CBA/Ca ↔ C57BL/6J mouse aggregation chimeras, with the use of H-2 antigens as markers of cellular genotype. Each of 55 early neoplastic foci occurring at a mosaic patch boundary was composed of cells of a single genotype. Our results provide direct evidence that these foci arise from single crypts. In contrast, the epithelium of 5 of 17 larger adenomas was of mixed genotype: In 3, one genotype was represented only by a rim of cytologically normal epithelium derived from adjacent crypts, but in the other 2 the epithelium of both genotypes was dysplastic. One of these was probably a “collision” tumor arising from adjacent but independent foci; in the other, the minority component may have been derived from entrapped nonneoplastic crypts." @default.
- W1918604927 created "2016-06-24" @default.
- W1918604927 date "1986-10-01" @default.
- W1918604927 modified "2023-09-25" @default.
- W1918604927 title "Direct Examination of the Clonality of Carcinogen-Induced Colonic Epithelial Dysplasia in Chimeric Mice<xref ref-type=fn rid=FN2>2</xref>" @default.
- W1918604927 doi "https://doi.org/10.1093/jnci/77.4.967" @default.
- W1918604927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3463823" @default.
- W1918604927 hasPublicationYear "1986" @default.
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