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• W1918610557 endingPage "e0141581" @default.
• W1918610557 startingPage "e0141581" @default.
• W1918610557 abstract "Bone marrow stromal cells (BMSCs) are considered as candidates for regenerative therapy and a useful model for studying neuronal differentiation. The role of basic fibroblast growth factor (bFGF) in neuronal differentiation has been previously studied; however, the signaling pathway involved in this process remains poorly understood. In this study, we investigated the signaling pathway in the bFGF-induced neuronal differentiation of canine BMSCs. bFGF induced the mRNA expression of the neuron marker, microtubule associated protein-2 (MAP2) and the neuron-like morphological change in canine BMSCs. In the presence of inhibitors of fibroblast growth factor receptors (FGFR), phosphatidylinositol 3-kinase (PI3K) and Akt, i.e., SU5402, LY294002, and MK2206, respectively, bFGF failed to induce the MAP2 mRNA expression and the neuron-like morphological change. bFGF induced Akt phosphorylation, but it was attenuated by the FGFR inhibitor SU5402 and the PI3K inhibitor LY294002. In canine BMSCs, expression of FGFR-1 and FGFR-2 was confirmed, but only FGFR-2 activation was detected by cross-linking and immunoprecipitation analysis. Small interfering RNA-mediated knockdown of FGFR-2 in canine BMSCs resulted in the attenuation of bFGF-induced Akt phosphorylation. These results suggest that the FGFR-2/PI3K/Akt signaling pathway is involved in the bFGF-induced neuronal differentiation of canine BMSCs." @default.
• W1918610557 created "2016-06-24" @default.
• W1918610557 creator A5000369889 @default.
• W1918610557 creator A5037633999 @default.
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• W1918610557 creator A5069348272 @default.
• W1918610557 creator A5075444660 @default.
• W1918610557 creator A5084105797 @default.
• W1918610557 date "2015-11-02" @default.
• W1918610557 modified "2023-10-12" @default.
• W1918610557 title "Fibroblast Growth Factor Receptor-2 Contributes to the Basic Fibroblast Growth Factor-Induced Neuronal Differentiation in Canine Bone Marrow Stromal Cells via Phosphoinositide 3-Kinase/Akt Signaling Pathway" @default.
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• W1918610557 doi "https://doi.org/10.1371/journal.pone.0141581" @default.
• W1918610557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4629880" @default.
• W1918610557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26523832" @default.
• W1918610557 hasPublicationYear "2015" @default.
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