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- W1918637778 abstract "Analysis of a complex protein mixture is one of the main topics in proteomics. While the traditional 2D-PAGE method separates proteins first and then identifies each spot, an alternative method was proposed which cleavages the whole protein mixture with an enzyme like trypsin, separates the resulted peptide fragments with multi-dimensional LC, identifies each fragment with mass spectrometry, and then reconstructs the protein components via database searching [3, 6]. Although this new methodology is very promising, it cannot detect proteins that do not exist in databases or the corresponding DNA sequences are not known. We investigated a new shotgun approach using multiple cleavage schemes and a peptide assembly program. Ideal peptide fragments resulting from multiple digestions with several peptidases partially overlap each other and can be assembled as shotgun sequencing of DNA fragments. Starting from the non-redundant set of proteome in the SWISS-PROT database, we theoretically generated peptide fragments and used it as a test set. Our simulation showed that a part of the original complex protein mixture could be identified without any additional information other than short peptide sequences and masses of original proteins." @default.
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- W1918637778 date "2001-12-10" @default.
- W1918637778 modified "2023-10-14" @default.
- W1918637778 title "PepAssem, a Peptide Assembly Algorithm for a Complex Protein Mixture" @default.
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- W1918637778 doi "https://doi.org/10.11234/gi1990.12.366" @default.
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