FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1918791454> ?p ?o ?g. }

• W1918791454 endingPage "825" @default.
• W1918791454 startingPage "814" @default.
• W1918791454 abstract "Antibody-directed enzyme prodrug therapy (ADEPT) requires highly selective antibody-mediated delivery of enzyme to tumor. MFE-CP, a multifunctional genetic fusion protein of antibody and enzyme, was designed to achieve this by two mechanisms. First by using a high affinity and high specificity single chain Fv antibody directed to carcinoembryonic antigen. Second by rapid removal of antibody-enzyme from normal tissues by virtue of post-translational mannosylation. The purpose of this paper is to investigate these dual functions in an animal model of pharmacokinetics, pharmacodynamics, toxicity, and efficacy.MFE-CP was expressed in the yeast Pichia pastoris and purified via an engineered hexahistidine tag. Biodistribution and therapeutic effect of a single ADEPT cycle (1,000 units/kg MFE-CP followed by 70 mg/kg ZD2767P prodrug at 6, 7, and 8 hours) and multiple ADEPT cycles (9-10 cycles within 21-24 days) was studied in established human colon carcinoma xenografts, LS174T, and SW1222.Selective localization of functional enzyme in tumors and rapid clearance from plasma was observed within 6 hours, resulting in tumor to plasma ratios of 1,400:1 and 339:1, respectively for the LS174T and SW1222 models. A single ADEPT cycle produced reproducible tumor growth delay in both models. Multiple ADEPT cycles significantly enhanced the therapeutic effect of a single cycle in the LS174T xenografts (P = 0.001) and produced regressions in the SW1222 xenografts (P = 0.0001), with minimal toxicity.MFE-CP fusion protein, in combination with ZD2767P, provides a new and successful ADEPT system, which offers the potential for multiple cycles and antitumor efficacy. These results provide a basis for the next stage in clinical development of ADEPT." @default.
• W1918791454 created "2016-06-24" @default.
• W1918791454 creator A5005915845 @default.
• W1918791454 creator A5010881489 @default.
• W1918791454 creator A5033754216 @default.
• W1918791454 creator A5039958347 @default.
• W1918791454 creator A5040445316 @default.
• W1918791454 creator A5057333549 @default.
• W1918791454 creator A5067537664 @default.
• W1918791454 creator A5067711058 @default.
• W1918791454 creator A5074353747 @default.
• W1918791454 creator A5074759125 @default.
• W1918791454 creator A5083945518 @default.
• W1918791454 creator A5091106436 @default.
• W1918791454 date "2005-01-15" @default.
• W1918791454 modified "2023-10-10" @default.
• W1918791454 title "Sustained Tumor Regression of Human Colorectal Cancer Xenografts Using a Multifunctional Mannosylated Fusion Protein in Antibody-Directed Enzyme Prodrug Therapy" @default.
• W1918791454 cites W1527643427 @default.
• W1918791454 cites W1964196039 @default.
• W1918791454 cites W1979962590 @default.
• W1918791454 cites W1980375208 @default.
• W1918791454 cites W1981793850 @default.
• W1918791454 cites W1982987387 @default.
• W1918791454 cites W1983430641 @default.
• W1918791454 cites W1983748607 @default.
• W1918791454 cites W1987065191 @default.
• W1918791454 cites W1997519980 @default.
• W1918791454 cites W2011478427 @default.
• W1918791454 cites W2018358531 @default.
• W1918791454 cites W2022770804 @default.
• W1918791454 cites W2025882541 @default.
• W1918791454 cites W2032235646 @default.
• W1918791454 cites W2034323454 @default.
• W1918791454 cites W2043913598 @default.
• W1918791454 cites W2048282271 @default.
• W1918791454 cites W2051692797 @default.
• W1918791454 cites W2054542253 @default.
• W1918791454 cites W2065338516 @default.
• W1918791454 cites W2076024702 @default.
• W1918791454 cites W2079185876 @default.
• W1918791454 cites W2079187574 @default.
• W1918791454 cites W2095388870 @default.
• W1918791454 cites W2100988726 @default.
• W1918791454 cites W2117652061 @default.
• W1918791454 cites W2128951247 @default.
• W1918791454 cites W2141445667 @default.
• W1918791454 cites W2166557837 @default.
• W1918791454 cites W2170981135 @default.
• W1918791454 cites W2328372869 @default.
• W1918791454 cites W2949103399 @default.
• W1918791454 cites W3038566374 @default.
• W1918791454 doi "https://doi.org/10.1158/1078-0432.814.11.2" @default.
• W1918791454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15701872" @default.
• W1918791454 hasPublicationYear "2005" @default.
• W1918791454 type Work @default.
• W1918791454 sameAs 1918791454 @default.
• W1918791454 citedByCount "55" @default.
• W1918791454 countsByYear W19187914542012 @default.
• W1918791454 countsByYear W19187914542013 @default.
• W1918791454 countsByYear W19187914542014 @default.
• W1918791454 countsByYear W19187914542015 @default.
• W1918791454 countsByYear W19187914542016 @default.
• W1918791454 countsByYear W19187914542017 @default.
• W1918791454 countsByYear W19187914542018 @default.
• W1918791454 countsByYear W19187914542019 @default.
• W1918791454 countsByYear W19187914542023 @default.
• W1918791454 crossrefType "journal-article" @default.
• W1918791454 hasAuthorship W1918791454A5005915845 @default.
• W1918791454 hasAuthorship W1918791454A5010881489 @default.
• W1918791454 hasAuthorship W1918791454A5033754216 @default.
• W1918791454 hasAuthorship W1918791454A5039958347 @default.
• W1918791454 hasAuthorship W1918791454A5040445316 @default.
• W1918791454 hasAuthorship W1918791454A5057333549 @default.
• W1918791454 hasAuthorship W1918791454A5067537664 @default.
• W1918791454 hasAuthorship W1918791454A5067711058 @default.
• W1918791454 hasAuthorship W1918791454A5074353747 @default.
• W1918791454 hasAuthorship W1918791454A5074759125 @default.
• W1918791454 hasAuthorship W1918791454A5083945518 @default.
• W1918791454 hasAuthorship W1918791454A5091106436 @default.
• W1918791454 hasBestOaLocation W19187914541 @default.
• W1918791454 hasConcept C104317684 @default.
• W1918791454 hasConcept C108215921 @default.
• W1918791454 hasConcept C112705442 @default.
• W1918791454 hasConcept C121608353 @default.
• W1918791454 hasConcept C123894998 @default.
• W1918791454 hasConcept C126322002 @default.
• W1918791454 hasConcept C159654299 @default.
• W1918791454 hasConcept C181199279 @default.
• W1918791454 hasConcept C185592680 @default.
• W1918791454 hasConcept C19831878 @default.
• W1918791454 hasConcept C202751555 @default.
• W1918791454 hasConcept C203014093 @default.
• W1918791454 hasConcept C2776904630 @default.
• W1918791454 hasConcept C2777387746 @default.
• W1918791454 hasConcept C2777807558 @default.
• W1918791454 hasConcept C2780035454 @default.
• W1918791454 hasConcept C40767141 @default.
• W1918791454 hasConcept C502942594 @default.

• next