Matches in SemOpenAlex for { <https://semopenalex.org/work/W1918843907> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1918843907 endingPage "935" @default.
- W1918843907 startingPage "926" @default.
- W1918843907 abstract "Summary In this report, we describe the involvement of TatD nuclease during programmed cell death (PCD) in the human protozoan parasite Trypanosoma brucei . T. brucei TatD nuclease showed intrinsic DNase activity, was localized in the cytoplasm and translocated to the nucleus when cells were treated with inducers previously demonstrated to cause PCD in T. brucei . Overexpression of TatD nuclease resulted in elevated PCD and conversely, loss of TatD expression by RNAi conferred significant resistance to the induction of PCD in T. brucei . Co‐immunoprecipitation studies revealed that TatD nuclease interacts with endonucleaseG suggesting that these two nucleases could form a DNA degradation complex in the nucleus. Together, biochemical activity, RNAi and subcellular localization results demonstrate the role of TatD nuclease activity in DNA degradation during PCD in these evolutionarily ancient eukaryotic organisms. Further, in conjunction with endonucleaseG, TatD may represent a critical nuclease in a caspase‐independent PCD pathway in trypanosomatid parasites since caspases have not been identified in these organisms." @default.
- W1918843907 created "2016-06-24" @default.
- W1918843907 creator A5046136787 @default.
- W1918843907 creator A5089647417 @default.
- W1918843907 date "2012-01-31" @default.
- W1918843907 modified "2023-10-15" @default.
- W1918843907 title "Involvement of TatD nuclease during programmed cell death in the protozoan parasite Trypanosoma brucei" @default.
- W1918843907 cites W1819638116 @default.
- W1918843907 cites W1973767731 @default.
- W1918843907 cites W1980792888 @default.
- W1918843907 cites W2014973634 @default.
- W1918843907 cites W2019520714 @default.
- W1918843907 cites W2021189028 @default.
- W1918843907 cites W2021327083 @default.
- W1918843907 cites W2025327454 @default.
- W1918843907 cites W2026339411 @default.
- W1918843907 cites W2029320528 @default.
- W1918843907 cites W2029867013 @default.
- W1918843907 cites W2033031248 @default.
- W1918843907 cites W2033376776 @default.
- W1918843907 cites W2042489141 @default.
- W1918843907 cites W2074200686 @default.
- W1918843907 cites W2075635047 @default.
- W1918843907 cites W2075915930 @default.
- W1918843907 cites W2078027213 @default.
- W1918843907 cites W2083021096 @default.
- W1918843907 cites W2105736543 @default.
- W1918843907 cites W2107041612 @default.
- W1918843907 cites W2116160457 @default.
- W1918843907 cites W2116350092 @default.
- W1918843907 cites W2135725493 @default.
- W1918843907 cites W2138846998 @default.
- W1918843907 cites W2160888554 @default.
- W1918843907 doi "https://doi.org/10.1111/j.1365-2958.2012.07978.x" @default.
- W1918843907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22288397" @default.
- W1918843907 hasPublicationYear "2012" @default.
- W1918843907 type Work @default.
- W1918843907 sameAs 1918843907 @default.
- W1918843907 citedByCount "18" @default.
- W1918843907 countsByYear W19188439072012 @default.
- W1918843907 countsByYear W19188439072014 @default.
- W1918843907 countsByYear W19188439072015 @default.
- W1918843907 countsByYear W19188439072016 @default.
- W1918843907 countsByYear W19188439072019 @default.
- W1918843907 countsByYear W19188439072020 @default.
- W1918843907 countsByYear W19188439072021 @default.
- W1918843907 countsByYear W19188439072022 @default.
- W1918843907 countsByYear W19188439072023 @default.
- W1918843907 crossrefType "journal-article" @default.
- W1918843907 hasAuthorship W1918843907A5046136787 @default.
- W1918843907 hasAuthorship W1918843907A5089647417 @default.
- W1918843907 hasConcept C104317684 @default.
- W1918843907 hasConcept C153911025 @default.
- W1918843907 hasConcept C190062978 @default.
- W1918843907 hasConcept C190283241 @default.
- W1918843907 hasConcept C2777271071 @default.
- W1918843907 hasConcept C2779502636 @default.
- W1918843907 hasConcept C31573885 @default.
- W1918843907 hasConcept C54355233 @default.
- W1918843907 hasConcept C552990157 @default.
- W1918843907 hasConcept C86803240 @default.
- W1918843907 hasConcept C95444343 @default.
- W1918843907 hasConcept C98424977 @default.
- W1918843907 hasConceptScore W1918843907C104317684 @default.
- W1918843907 hasConceptScore W1918843907C153911025 @default.
- W1918843907 hasConceptScore W1918843907C190062978 @default.
- W1918843907 hasConceptScore W1918843907C190283241 @default.
- W1918843907 hasConceptScore W1918843907C2777271071 @default.
- W1918843907 hasConceptScore W1918843907C2779502636 @default.
- W1918843907 hasConceptScore W1918843907C31573885 @default.
- W1918843907 hasConceptScore W1918843907C54355233 @default.
- W1918843907 hasConceptScore W1918843907C552990157 @default.
- W1918843907 hasConceptScore W1918843907C86803240 @default.
- W1918843907 hasConceptScore W1918843907C95444343 @default.
- W1918843907 hasConceptScore W1918843907C98424977 @default.
- W1918843907 hasIssue "5" @default.
- W1918843907 hasLocation W19188439071 @default.
- W1918843907 hasLocation W19188439072 @default.
- W1918843907 hasOpenAccess W1918843907 @default.
- W1918843907 hasPrimaryLocation W19188439071 @default.
- W1918843907 hasRelatedWork W1670069535 @default.
- W1918843907 hasRelatedWork W1724254908 @default.
- W1918843907 hasRelatedWork W1966994924 @default.
- W1918843907 hasRelatedWork W1996479442 @default.
- W1918843907 hasRelatedWork W2024445545 @default.
- W1918843907 hasRelatedWork W2100194182 @default.
- W1918843907 hasRelatedWork W2138509357 @default.
- W1918843907 hasRelatedWork W2268189697 @default.
- W1918843907 hasRelatedWork W2347878564 @default.
- W1918843907 hasRelatedWork W2413170079 @default.
- W1918843907 hasVolume "83" @default.
- W1918843907 isParatext "false" @default.
- W1918843907 isRetracted "false" @default.
- W1918843907 magId "1918843907" @default.
- W1918843907 workType "article" @default.