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- W1918973414 endingPage "2017" @default.
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- W1918973414 abstract "Abstract To generate T cells throughout adult life, the thymus must import hemopoietic progenitors from the bone marrow via the blood. In this study, we establish that thymus settling is selective. Using nonirradiated recipient mice, we found that hemopoietic stem cells were excluded from the thymus, whereas downstream multipotent progenitors (MPP) and common lymphoid progenitors rapidly generated T cells following i.v. transfer. This cellular specificity correlated with the expression of the chemokine receptor CCR9 by a subset of MPP and common lymphoid progenitors but not hemopoietic stem cells. Furthermore, CCR9 expression was required for efficient thymus settling. Finally, we demonstrate that a prethymic signal through the cytokine receptor fms-like tyrosine kinase receptor-3 was required for the generation of CCR9-expressing early lymphoid progenitors, which were the most efficient progenitors of T cells within the MPP population. We conclude that fms-like tyrosine kinase receptor-3 signaling is required for the generation of T lineage-competent progenitors, which selectively express molecules, including CCR9, that allow them to settle within the thymus." @default.
- W1918973414 created "2016-06-24" @default.
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- W1918973414 date "2007-02-15" @default.
- W1918973414 modified "2023-10-12" @default.
- W1918973414 title "Selective Thymus Settling Regulated by Cytokine and Chemokine Receptors" @default.
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- W1918973414 doi "https://doi.org/10.4049/jimmunol.178.4.2008" @default.
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