Matches in SemOpenAlex for { <https://semopenalex.org/work/W1919161738> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1919161738 startingPage "1952" @default.
- W1919161738 abstract "Introduction: Aim of this study was to examine quantitative methylation patterns using pyrosequencing in multiple genes in tumor, matching normal lung tissue and blood of patients with non-small cell lung cancer. We also analyzed possible associations between clinicopathologic features of patients and DNA methylation. Material and methods: Primary tumor samples (n=65), corresponding nonmalignant lung tissues (n=65) and blood samples (n=51) were obtained from NSCLC patients, treated with curative resectional surgery. Hypermethylation status was quantified at multiple CpG sites within each promoter in multiple genes- SOX1, RASSF1A, HOXA9, CDH13, MGMT, ESR1 and DAPK by pyrosequencing. Results: For most of the genes there was a significant difference between tumor methylation, normal tissue and blood samples. Methylation in tumors was significantly higher then in normal lung for SOX1, DAPK, RASSF1A, HOXA9 and CDH13. Tumor hypermethylation was more frequently for adenocarcinoma at CDH13 and ESR1. A higher proportion of SSC tumors were hypermethylated at HOXA9 and SOX1 compared to other types of NSCLC. Patients with stage four more likely had hypermethylation at MGMT and patients with hypermethylation at HOX9 more likely had stage two and three tumors. Gender was associated with hypermethylation at CDH13 with females being more likely to have hypermethylated tumors. Conclusion: Our results show that elevated methylation levels observed in genes SOX1, RASSF1A, HOXA9, CDH13, MGMT, ESR1 and DAPK were cancer-specific and associated with some clinicopathologic features of patients." @default.
- W1919161738 created "2016-06-24" @default.
- W1919161738 creator A5002292616 @default.
- W1919161738 creator A5015258786 @default.
- W1919161738 creator A5025349600 @default.
- W1919161738 creator A5051289927 @default.
- W1919161738 creator A5065535459 @default.
- W1919161738 creator A5071933268 @default.
- W1919161738 creator A5087715425 @default.
- W1919161738 date "2011-09-01" @default.
- W1919161738 modified "2023-09-23" @default.
- W1919161738 title "Quantitative methylation profiles of multiple genes in patients with non-small cell lung cancer and its association with clinicopathological correlations" @default.
- W1919161738 hasPublicationYear "2011" @default.
- W1919161738 type Work @default.
- W1919161738 sameAs 1919161738 @default.
- W1919161738 citedByCount "1" @default.
- W1919161738 countsByYear W19191617382015 @default.
- W1919161738 crossrefType "journal-article" @default.
- W1919161738 hasAuthorship W1919161738A5002292616 @default.
- W1919161738 hasAuthorship W1919161738A5015258786 @default.
- W1919161738 hasAuthorship W1919161738A5025349600 @default.
- W1919161738 hasAuthorship W1919161738A5051289927 @default.
- W1919161738 hasAuthorship W1919161738A5065535459 @default.
- W1919161738 hasAuthorship W1919161738A5071933268 @default.
- W1919161738 hasAuthorship W1919161738A5087715425 @default.
- W1919161738 hasConcept C104317684 @default.
- W1919161738 hasConcept C121608353 @default.
- W1919161738 hasConcept C126322002 @default.
- W1919161738 hasConcept C140173407 @default.
- W1919161738 hasConcept C142724271 @default.
- W1919161738 hasConcept C143998085 @default.
- W1919161738 hasConcept C146357865 @default.
- W1919161738 hasConcept C150194340 @default.
- W1919161738 hasConcept C151730666 @default.
- W1919161738 hasConcept C190727270 @default.
- W1919161738 hasConcept C2776256026 @default.
- W1919161738 hasConcept C2777714996 @default.
- W1919161738 hasConcept C2781182431 @default.
- W1919161738 hasConcept C33288867 @default.
- W1919161738 hasConcept C502942594 @default.
- W1919161738 hasConcept C54355233 @default.
- W1919161738 hasConcept C71924100 @default.
- W1919161738 hasConcept C86803240 @default.
- W1919161738 hasConceptScore W1919161738C104317684 @default.
- W1919161738 hasConceptScore W1919161738C121608353 @default.
- W1919161738 hasConceptScore W1919161738C126322002 @default.
- W1919161738 hasConceptScore W1919161738C140173407 @default.
- W1919161738 hasConceptScore W1919161738C142724271 @default.
- W1919161738 hasConceptScore W1919161738C143998085 @default.
- W1919161738 hasConceptScore W1919161738C146357865 @default.
- W1919161738 hasConceptScore W1919161738C150194340 @default.
- W1919161738 hasConceptScore W1919161738C151730666 @default.
- W1919161738 hasConceptScore W1919161738C190727270 @default.
- W1919161738 hasConceptScore W1919161738C2776256026 @default.
- W1919161738 hasConceptScore W1919161738C2777714996 @default.
- W1919161738 hasConceptScore W1919161738C2781182431 @default.
- W1919161738 hasConceptScore W1919161738C33288867 @default.
- W1919161738 hasConceptScore W1919161738C502942594 @default.
- W1919161738 hasConceptScore W1919161738C54355233 @default.
- W1919161738 hasConceptScore W1919161738C71924100 @default.
- W1919161738 hasConceptScore W1919161738C86803240 @default.
- W1919161738 hasOpenAccess W1919161738 @default.
- W1919161738 hasRelatedWork W1791425304 @default.
- W1919161738 hasRelatedWork W1964017123 @default.
- W1919161738 hasRelatedWork W2012975001 @default.
- W1919161738 hasRelatedWork W2022370858 @default.
- W1919161738 hasRelatedWork W2034523988 @default.
- W1919161738 hasRelatedWork W2037010522 @default.
- W1919161738 hasRelatedWork W2037174835 @default.
- W1919161738 hasRelatedWork W2071860733 @default.
- W1919161738 hasRelatedWork W2118532559 @default.
- W1919161738 hasRelatedWork W2133810641 @default.
- W1919161738 hasRelatedWork W2150682829 @default.
- W1919161738 hasRelatedWork W2350751233 @default.
- W1919161738 hasRelatedWork W2356695598 @default.
- W1919161738 hasRelatedWork W2358902376 @default.
- W1919161738 hasRelatedWork W2361733229 @default.
- W1919161738 hasRelatedWork W2362407711 @default.
- W1919161738 hasRelatedWork W2368536895 @default.
- W1919161738 hasRelatedWork W2372243376 @default.
- W1919161738 hasRelatedWork W2425634552 @default.
- W1919161738 hasRelatedWork W3025999547 @default.
- W1919161738 hasVolume "38" @default.
- W1919161738 isParatext "false" @default.
- W1919161738 isRetracted "false" @default.
- W1919161738 magId "1919161738" @default.
- W1919161738 workType "article" @default.