FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1919362256> ?p ?o ?g. }

• W1919362256 endingPage "955" @default.
• W1919362256 startingPage "944" @default.
• W1919362256 abstract "External and internal stimuli that threaten homeostasis trigger coordinated stress responses through activation of specialised neuroendocrine circuits. In mammals, the hypothalamic-pituitary-adrenal (HPA) axis mediates responses to stressors such as restraint, ultimately enhancing adrenocortical hormone secretion. Pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in central control of the HPA axis, and we have recently shown PACAP-dependent expression of corticotropin-releasing hormone (CRH) and secretion of corticosterone in response to restraint. We now provide a more detailed analysis of PACAP-dependent HPA axis stimulation in the mouse, indicating that the hypothalamic paraventricular nucleus (PVN) is the primary site of action. We demonstrate by quantitative polymerase chain reaction and in situ hybridisation that up-regulation of mRNAs encoding CRH and inducible transcription factors, from the Nr4a family (Nur77, Nor1) in the PVN is PACAP-dependent. Furthermore, CRH hnRNA is rapidly up-regulated in cultured hypothalamic neurones after treatment with PACAP. Induction of Nr4a factors (Nur77, Nurr1) in response to restraint is attenuated in the pituitary gland of PACAP-deficient mice. In the adrenal glands, restraint elicits a marked PACAP-dependent increase in adrenocortical mRNA levels of all three Nr4a transcription factors, steroidogenic factor 1 (Nr5a1), steroidogenic acute regulatory protein and steroid 21-hydroxylase. Taken together, our results show that PACAP controls HPA responses to restraint primarily at the level of the hypothalamus by up-regulating CRH, possibly involving transcription factors such as Nur77 and Nor1. Subsequent adrenocortical steroidogenesis also appears to involve PACAP-dependent stimulus-transcription coupling, suggesting a mechanism by which PACAP exerts control over HPA axis function during stress." @default.
• W1919362256 created "2016-06-24" @default.
• W1919362256 creator A5006224641 @default.
• W1919362256 creator A5010779419 @default.
• W1919362256 creator A5038866388 @default.
• W1919362256 creator A5060002817 @default.
• W1919362256 date "2011-09-23" @default.
• W1919362256 modified "2023-09-27" @default.
• W1919362256 title "Pituitary Adenylate Cyclase-Activating Polypeptide Controls Stimulus-Transcription Coupling in the Hypothalamic-Pituitary-Adrenal Axis to Mediate Sustained Hormone Secretion During Stress" @default.
• W1919362256 cites W1519700610 @default.
• W1919362256 cites W1633358180 @default.
• W1919362256 cites W1824948378 @default.
• W1919362256 cites W1847582680 @default.
• W1919362256 cites W1978220518 @default.
• W1919362256 cites W1991517325 @default.
• W1919362256 cites W1994386089 @default.
• W1919362256 cites W1996201127 @default.
• W1919362256 cites W2000264966 @default.
• W1919362256 cites W2005833530 @default.
• W1919362256 cites W2010001659 @default.
• W1919362256 cites W2019144427 @default.
• W1919362256 cites W2033293674 @default.
• W1919362256 cites W2033313592 @default.
• W1919362256 cites W2034816834 @default.
• W1919362256 cites W2035362985 @default.
• W1919362256 cites W2038104966 @default.
• W1919362256 cites W2045378677 @default.
• W1919362256 cites W2049566660 @default.
• W1919362256 cites W2056583482 @default.
• W1919362256 cites W2060121811 @default.
• W1919362256 cites W2069436500 @default.
• W1919362256 cites W2074244295 @default.
• W1919362256 cites W2076507733 @default.
• W1919362256 cites W2076849178 @default.
• W1919362256 cites W2084219713 @default.
• W1919362256 cites W2085770121 @default.
• W1919362256 cites W2090451467 @default.
• W1919362256 cites W2094581953 @default.
• W1919362256 cites W2095395905 @default.
• W1919362256 cites W2107277218 @default.
• W1919362256 cites W2109135671 @default.
• W1919362256 cites W2126940622 @default.
• W1919362256 cites W2134043536 @default.
• W1919362256 cites W2156827271 @default.
• W1919362256 cites W2163762391 @default.
• W1919362256 cites W2166767193 @default.
• W1919362256 cites W2192080449 @default.
• W1919362256 cites W2256830124 @default.
• W1919362256 cites W2438471694 @default.
• W1919362256 cites W4233476918 @default.
• W1919362256 cites W4239824508 @default.
• W1919362256 cites W4245332163 @default.
• W1919362256 cites W4251392063 @default.
• W1919362256 doi "https://doi.org/10.1111/j.1365-2826.2011.02202.x" @default.
• W1919362256 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3183119" @default.
• W1919362256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21824204" @default.
• W1919362256 hasPublicationYear "2011" @default.
• W1919362256 type Work @default.
• W1919362256 sameAs 1919362256 @default.
• W1919362256 citedByCount "52" @default.
• W1919362256 countsByYear W19193622562012 @default.
• W1919362256 countsByYear W19193622562013 @default.
• W1919362256 countsByYear W19193622562014 @default.
• W1919362256 countsByYear W19193622562015 @default.
• W1919362256 countsByYear W19193622562016 @default.
• W1919362256 countsByYear W19193622562017 @default.
• W1919362256 countsByYear W19193622562018 @default.
• W1919362256 countsByYear W19193622562019 @default.
• W1919362256 countsByYear W19193622562020 @default.
• W1919362256 countsByYear W19193622562021 @default.
• W1919362256 countsByYear W19193622562022 @default.
• W1919362256 countsByYear W19193622562023 @default.
• W1919362256 crossrefType "journal-article" @default.
• W1919362256 hasAuthorship W1919362256A5006224641 @default.
• W1919362256 hasAuthorship W1919362256A5010779419 @default.
• W1919362256 hasAuthorship W1919362256A5038866388 @default.
• W1919362256 hasAuthorship W1919362256A5060002817 @default.
• W1919362256 hasBestOaLocation W19193622562 @default.
• W1919362256 hasConcept C118303440 @default.
• W1919362256 hasConcept C126322002 @default.
• W1919362256 hasConcept C134018914 @default.
• W1919362256 hasConcept C170493617 @default.
• W1919362256 hasConcept C185592680 @default.
• W1919362256 hasConcept C2777003273 @default.
• W1919362256 hasConcept C2778458438 @default.
• W1919362256 hasConcept C2779496938 @default.
• W1919362256 hasConcept C2780352252 @default.
• W1919362256 hasConcept C71315377 @default.
• W1919362256 hasConcept C71924100 @default.
• W1919362256 hasConcept C8330315 @default.
• W1919362256 hasConcept C86803240 @default.
• W1919362256 hasConceptScore W1919362256C118303440 @default.
• W1919362256 hasConceptScore W1919362256C126322002 @default.
• W1919362256 hasConceptScore W1919362256C134018914 @default.
• W1919362256 hasConceptScore W1919362256C170493617 @default.
• W1919362256 hasConceptScore W1919362256C185592680 @default.
• W1919362256 hasConceptScore W1919362256C2777003273 @default.
• W1919362256 hasConceptScore W1919362256C2778458438 @default.

• next