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- W1919419036 abstract "IL-7 is a member of the common gamma-chain family of cytokines sharing a common gamma-chain in their receptor. Beyond its long-established pivotal role in immune development, it has been more recently recognized as a critically important regulator of peripheral naïve and memory T cell homeostasis while its role in postdevelopment thymic function remains at best, poorly defined, and controversial. Its multiple immune-enhancing properties, most notably in the maintenance of T cell homeostasis, make it a very attractive candidate for immunotherapy in a wide variety of clinical situations. Following many years of rich preclinical data in murine and simian models, IL-7 is now emerging in human phase I trials as a very promising immunotherapeutic agent. Human in vivo data discussed here are derived from the phase I study initiated at the National Cancer Institute in collaboration with Cytheris, Inc., in a cohort of subjects with incurable malignancy." @default.
- W1919419036 created "2016-06-24" @default.
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- W1919419036 date "2007-01-01" @default.
- W1919419036 modified "2023-10-15" @default.
- W1919419036 title "Interleukin-7 Immunotherapy" @default.
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- W1919419036 doi "https://doi.org/10.1007/978-0-387-72005-0_35" @default.
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