FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1919506961> ?p ?o ?g. }

• W1919506961 endingPage "828" @default.
• W1919506961 startingPage "816" @default.
• W1919506961 abstract "Baculovirus infection boosts the host biosynthetic activity towards the production of viral components and the recombinant protein of interest, hyper-productive phenotypes being the result of a successful adaptation of the cellular network to that scenario. Spodoptera frugiperda derived Sf9 and Trichoplusia ni derived High Five cell lines have a major track record for the production of recombinant proteins, with High Five cells presenting higher productivities. A metabolic profiling of the two insect cell lines was pursued to underpin specific cellular traits behind productive phenotypes. Multivariate analysis identified cell-line dependent metabolic signatures linked to productivity. Pathway analysis highlighted cellular pathways of paramount importance in supporting infection and protein production. Moreover, better producer phenotypes proved to be correlated with the capacity of cells to shift their metabolism in favor of energy-generating pathways to fuel biosynthesis, a scenario observed in the High Five cell line. Metabolomic profiling allowed us to identify metabolic pathways involved in infection and recombinant protein production, which can be selected as targets for further improvement of the system." @default.
• W1919506961 created "2016-06-24" @default.
• W1919506961 creator A5021060711 @default.
• W1919506961 creator A5032022895 @default.
• W1919506961 creator A5035687272 @default.
• W1919506961 creator A5041231390 @default.
• W1919506961 creator A5049000541 @default.
• W1919506961 creator A5070224625 @default.
• W1919506961 creator A5081940334 @default.
• W1919506961 creator A5084533796 @default.
• W1919506961 date "2013-11-20" @default.
• W1919506961 modified "2023-09-25" @default.
• W1919506961 title "Metabolic profiling of insect cell lines: Unveiling cell line determinants behind system's productivity" @default.
• W1919506961 cites W1972684176 @default.
• W1919506961 cites W1973369975 @default.
• W1919506961 cites W1973762921 @default.
• W1919506961 cites W1974517984 @default.
• W1919506961 cites W1979034801 @default.
• W1919506961 cites W1982185581 @default.
• W1919506961 cites W1986406786 @default.
• W1919506961 cites W1986919632 @default.
• W1919506961 cites W1997705682 @default.
• W1919506961 cites W2005812290 @default.
• W1919506961 cites W2007302206 @default.
• W1919506961 cites W2009853885 @default.
• W1919506961 cites W2010821699 @default.
• W1919506961 cites W2011238864 @default.
• W1919506961 cites W2015612415 @default.
• W1919506961 cites W2016855149 @default.
• W1919506961 cites W2027406112 @default.
• W1919506961 cites W2028332226 @default.
• W1919506961 cites W2031693543 @default.
• W1919506961 cites W2034105408 @default.
• W1919506961 cites W2036461441 @default.
• W1919506961 cites W2041162400 @default.
• W1919506961 cites W2046910842 @default.
• W1919506961 cites W2051945227 @default.
• W1919506961 cites W2052434790 @default.
• W1919506961 cites W2053180447 @default.
• W1919506961 cites W2053947788 @default.
• W1919506961 cites W2062675287 @default.
• W1919506961 cites W2068438294 @default.
• W1919506961 cites W2072801133 @default.
• W1919506961 cites W2075172158 @default.
• W1919506961 cites W2078064578 @default.
• W1919506961 cites W2080232160 @default.
• W1919506961 cites W2083824802 @default.
• W1919506961 cites W2083891463 @default.
• W1919506961 cites W2094000957 @default.
• W1919506961 cites W2102385356 @default.
• W1919506961 cites W2135607659 @default.
• W1919506961 cites W2144954025 @default.
• W1919506961 cites W2162005401 @default.
• W1919506961 cites W2163226756 @default.
• W1919506961 cites W2177909750 @default.
• W1919506961 cites W4243566143 @default.
• W1919506961 cites W4247088117 @default.
• W1919506961 doi "https://doi.org/10.1002/bit.25142" @default.
• W1919506961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24258249" @default.
• W1919506961 hasPublicationYear "2013" @default.
• W1919506961 type Work @default.
• W1919506961 sameAs 1919506961 @default.
• W1919506961 citedByCount "24" @default.
• W1919506961 countsByYear W19195069612013 @default.
• W1919506961 countsByYear W19195069612014 @default.
• W1919506961 countsByYear W19195069612015 @default.
• W1919506961 countsByYear W19195069612016 @default.
• W1919506961 countsByYear W19195069612017 @default.
• W1919506961 countsByYear W19195069612018 @default.
• W1919506961 countsByYear W19195069612019 @default.
• W1919506961 countsByYear W19195069612020 @default.
• W1919506961 countsByYear W19195069612022 @default.
• W1919506961 countsByYear W19195069612023 @default.
• W1919506961 crossrefType "journal-article" @default.
• W1919506961 hasAuthorship W1919506961A5021060711 @default.
• W1919506961 hasAuthorship W1919506961A5032022895 @default.
• W1919506961 hasAuthorship W1919506961A5035687272 @default.
• W1919506961 hasAuthorship W1919506961A5041231390 @default.
• W1919506961 hasAuthorship W1919506961A5049000541 @default.
• W1919506961 hasAuthorship W1919506961A5070224625 @default.
• W1919506961 hasAuthorship W1919506961A5081940334 @default.
• W1919506961 hasAuthorship W1919506961A5084533796 @default.
• W1919506961 hasConcept C103878061 @default.
• W1919506961 hasConcept C104317684 @default.
• W1919506961 hasConcept C127716648 @default.
• W1919506961 hasConcept C173758957 @default.
• W1919506961 hasConcept C18903297 @default.
• W1919506961 hasConcept C192989942 @default.
• W1919506961 hasConcept C21565614 @default.
• W1919506961 hasConcept C2777212814 @default.
• W1919506961 hasConcept C2777773057 @default.
• W1919506961 hasConcept C2778350275 @default.
• W1919506961 hasConcept C2779341487 @default.
• W1919506961 hasConcept C40767141 @default.
• W1919506961 hasConcept C54355233 @default.
• W1919506961 hasConcept C55493867 @default.
• W1919506961 hasConcept C60644358 @default.
• W1919506961 hasConcept C62231903 @default.

• next