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- W1919553612 abstract "Multidrug resistance (MDR) remains one of the key determinants in chemotherapeutic success of cancer patients. Often, acquired resistance is mediated by the overexpression of ATP-binding cassette (ABC) drug transporters. To study the mechanisms involved in the MDR phenotype, investigators have generated a variety of in vitro cell culture models using both multi-step and single-step drug selections. Sublines produced from multi-step selections have led to the discovery of several crucial drug transporters including ABCB1, ABCC1, and ABCG2. Additionally, a number of mechanisms causing gene overexpression have been elucidated. To more closely mimic in vivo conditions, investigators have also established MDR sublines with single-step drug selections. Here, we examine some of the multi-step and single-step selected cell lines generated to elucidate the mechanisms involved in the development of MDR in cancer cells." @default.
- W1919553612 created "2016-06-24" @default.
- W1919553612 creator A5048564367 @default.
- W1919553612 creator A5081938413 @default.
- W1919553612 date "2009-10-05" @default.
- W1919553612 modified "2023-09-27" @default.
- W1919553612 title "Molecular Mechanisms of Drug Resistance in Single-Step and Multi-Step Drug-Selected Cancer Cells" @default.
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- W1919553612 doi "https://doi.org/10.1007/978-1-60761-416-6_5" @default.
- W1919553612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3099236" @default.
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