Matches in SemOpenAlex for { <https://semopenalex.org/work/W1919786088> ?p ?o ?g. }
- W1919786088 endingPage "3461" @default.
- W1919786088 startingPage "3452" @default.
- W1919786088 abstract "Autoimmune encephalomyelitis is a disease of the CNS that can develop when an initial peripheral inflammatory stimulus is followed by infiltration and reactivation of T lymphocytes in the CNS. We report a crucial role for coronin 1, which is essential for maintenance of the naive T cell pool, for the development of murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. In the absence of coronin 1, immunization with myelin oligoglycoprotein (MOG(35-55)) peptide largely failed to induce EAE symptoms, despite normal mobilization of leukocyte subsets in the blood, as well as effector cytokine expression comparable with wild-type T cells on polyclonal stimulation. Susceptibility of coronin 1-deficient mice to EAE induction was restored by transfer of wild-type CD4(+) T cells, suggesting that the observed resistance of coronin 1-deficient mice to EAE development is T cell intrinsic. Importantly, although coronin 1-deficient regulatory T cells (Tregs) showed a suppressor activity comparable with wild-type Tregs, Treg depletion failed to restore EAE development in coronin 1-deficient animals. These results suggest a hitherto unrecognized role of naive T cells in the development of autoimmune encephalomyelitis and reveal coronin 1 as a crucial modulator of EAE induction." @default.
- W1919786088 created "2016-06-24" @default.
- W1919786088 creator A5035701510 @default.
- W1919786088 creator A5044213528 @default.
- W1919786088 creator A5045807034 @default.
- W1919786088 creator A5050234494 @default.
- W1919786088 creator A5061695123 @default.
- W1919786088 creator A5076899076 @default.
- W1919786088 date "2011-03-15" @default.
- W1919786088 modified "2023-10-16" @default.
- W1919786088 title "Coronin 1-Mediated Naive T Cell Survival Is Essential for the Development of Autoimmune Encephalomyelitis" @default.
- W1919786088 cites W1483769055 @default.
- W1919786088 cites W1507751353 @default.
- W1919786088 cites W1640545866 @default.
- W1919786088 cites W1964456603 @default.
- W1919786088 cites W1965572078 @default.
- W1919786088 cites W1977238516 @default.
- W1919786088 cites W1982214865 @default.
- W1919786088 cites W1986365703 @default.
- W1919786088 cites W1998009350 @default.
- W1919786088 cites W2003850151 @default.
- W1919786088 cites W2009355727 @default.
- W1919786088 cites W2009630518 @default.
- W1919786088 cites W2013725496 @default.
- W1919786088 cites W2015637511 @default.
- W1919786088 cites W2023314253 @default.
- W1919786088 cites W2025465431 @default.
- W1919786088 cites W2030855335 @default.
- W1919786088 cites W2048492877 @default.
- W1919786088 cites W2053313675 @default.
- W1919786088 cites W2054235049 @default.
- W1919786088 cites W2054254705 @default.
- W1919786088 cites W2056519855 @default.
- W1919786088 cites W2062515891 @default.
- W1919786088 cites W2062762880 @default.
- W1919786088 cites W2063073550 @default.
- W1919786088 cites W2065186655 @default.
- W1919786088 cites W2065871536 @default.
- W1919786088 cites W2067043854 @default.
- W1919786088 cites W2078564225 @default.
- W1919786088 cites W2095029406 @default.
- W1919786088 cites W2096126216 @default.
- W1919786088 cites W2096618637 @default.
- W1919786088 cites W2097021075 @default.
- W1919786088 cites W2107529713 @default.
- W1919786088 cites W2108335498 @default.
- W1919786088 cites W2113345769 @default.
- W1919786088 cites W2118296597 @default.
- W1919786088 cites W2124759151 @default.
- W1919786088 cites W2131876870 @default.
- W1919786088 cites W2132909461 @default.
- W1919786088 cites W2141071831 @default.
- W1919786088 cites W2156546316 @default.
- W1919786088 cites W2159252214 @default.
- W1919786088 cites W4241890711 @default.
- W1919786088 cites W1991734867 @default.
- W1919786088 doi "https://doi.org/10.4049/jimmunol.1003491" @default.
- W1919786088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21289301" @default.
- W1919786088 hasPublicationYear "2011" @default.
- W1919786088 type Work @default.
- W1919786088 sameAs 1919786088 @default.
- W1919786088 citedByCount "21" @default.
- W1919786088 countsByYear W19197860882012 @default.
- W1919786088 countsByYear W19197860882013 @default.
- W1919786088 countsByYear W19197860882015 @default.
- W1919786088 countsByYear W19197860882016 @default.
- W1919786088 countsByYear W19197860882017 @default.
- W1919786088 countsByYear W19197860882018 @default.
- W1919786088 countsByYear W19197860882019 @default.
- W1919786088 countsByYear W19197860882020 @default.
- W1919786088 countsByYear W19197860882021 @default.
- W1919786088 crossrefType "journal-article" @default.
- W1919786088 hasAuthorship W1919786088A5035701510 @default.
- W1919786088 hasAuthorship W1919786088A5044213528 @default.
- W1919786088 hasAuthorship W1919786088A5045807034 @default.
- W1919786088 hasAuthorship W1919786088A5050234494 @default.
- W1919786088 hasAuthorship W1919786088A5061695123 @default.
- W1919786088 hasAuthorship W1919786088A5076899076 @default.
- W1919786088 hasBestOaLocation W19197860881 @default.
- W1919786088 hasConcept C169760540 @default.
- W1919786088 hasConcept C203014093 @default.
- W1919786088 hasConcept C2776090121 @default.
- W1919786088 hasConcept C2777899865 @default.
- W1919786088 hasConcept C2778486448 @default.
- W1919786088 hasConcept C2778531937 @default.
- W1919786088 hasConcept C2778609137 @default.
- W1919786088 hasConcept C2779357208 @default.
- W1919786088 hasConcept C2780640218 @default.
- W1919786088 hasConcept C529278444 @default.
- W1919786088 hasConcept C86803240 @default.
- W1919786088 hasConcept C8891405 @default.
- W1919786088 hasConceptScore W1919786088C169760540 @default.
- W1919786088 hasConceptScore W1919786088C203014093 @default.
- W1919786088 hasConceptScore W1919786088C2776090121 @default.
- W1919786088 hasConceptScore W1919786088C2777899865 @default.
- W1919786088 hasConceptScore W1919786088C2778486448 @default.
- W1919786088 hasConceptScore W1919786088C2778531937 @default.
- W1919786088 hasConceptScore W1919786088C2778609137 @default.