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• W1919832320 abstract "The purpose of this study was to evaluate the clinical efficacy and toxicity of simultaneous integrated dose reduction intensity‑modulated radiotherapy (SIR‑IMRT) applied to an elective nodal area of patients with limited‑stage small‑cell lung cancer (LS‑SCLC). Between January 2010 and March 2013, 52 patients with LS‑SCLC that was treated with SIR‑IMRT were retrospectively analyzed. A radiation dose of 54 Gy was administered in 30 fractions (1.8 Gy/fraction) to the planning target volume (PTV). Simultaneously, 60 Gy was administered in 30 fractions (2 Gy/fraction) to the planning gross tumor volume. Radiation‑related toxicities were estimated according to the Common Terminology Criteria for Adverse Events (version 3.0). Overall survival (OS), locoregional recurrence‑free survival and progression‑free survival were estimated using the Kaplan‑Meier method. By the last follow‑up, the median follow‑up time was 16.5 months, the median OS was 24.0 months, and 21 (40.4%) patients had experienced treatment failure. Of these patients, 5 (9.6%) patients developed in‑field recurrence (within the 95% isodose curve of the PTV) and 1 (1.9%) patient developed an out‑of‑field recurrence (not a distant metastasis). Grade 3 or higher treatment‑related pneumonia was observed in 4/52 (7.6%) patients, and grade 3 radiation‑related esophagitis was experienced by 2/52 (3.8%) patients. The results of this preliminary study suggest that SIR‑IMRT is safe and effective for patients with LS-SCLC and should be further evaluated in a large prospective clinical trial." @default.
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• W1919832320 date "2015-10-30" @default.
• W1919832320 modified "2023-09-29" @default.
• W1919832320 title "Simultaneous integrated dose reduction intensity-modulated radiotherapy applied to an elective nodal area of limited-stage small-cell lung cancer" @default.
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• W1919832320 doi "https://doi.org/10.3892/etm.2015.2835" @default.
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