Matches in SemOpenAlex for { <https://semopenalex.org/work/W1919877497> ?p ?o ?g. }
- W1919877497 endingPage "70" @default.
- W1919877497 startingPage "56" @default.
- W1919877497 abstract "Cell swelling and astrogliosis (manifested as an increase in GFAP) were evoked in isolated rat spinal cords of 4–21-day-old rats by incubation in either 50 mM K+ or hypotonic solution (235 mosmol kg-1). Application of K+ and hypotonic solution resulted at first in a decrease of extracellular space (ECS) volume fraction α (ECS volume/total tissue volume) and an increase in tortuosity λ (λ2 = free/apparent diffusion coefficient) in spinal gray (GM) and white matter (WM). These changes resulted from cell swelling, since the total water content (TW) in spinal cord was unchanged and the changes were blocked in Cl−-free solution and slowed down by furosemide and bumetanide. Diffusion in WM was anisotropic, i.e., more facilitated along fibers (x-axis) than across them (y- or z-axis). The increase of λy,z was greater than that of λx, reaching unusually high values above 2.4. In GM only, during continuous 45 min application, α and λ started to return towards control values, apparently due to cell shrinkage of previously swollen cells since TW remained unchanged. This return was blocked by fluoroacetate, suggesting that most of the changes were due to the swelling of glia. A 45 min application of 50 mM K+ and, to a lesser degree, of hypotonic solution evoked astrogliosis, which persisted after washing out these solutions with physiological saline. During astrogliosis λ increased again to values as high as 2.0, while α either returned to or increased above control values. This persistent increase in λ after washout was also found in WM, and, in addition, the typical diffusion anisotropy was diminished. Our data show that glial swelling and astrogliosis are associated with a persistent increase in ECS diffusion barriers. This could lead to the impairment of the diffusion of neuroactive substances, extrasynaptic transmission, “crosstalk” between synapses and neuron-glia communication. GLIA 25:56–70, 1999. © 1999 Wiley-Liss, Inc." @default.
- W1919877497 created "2016-06-24" @default.
- W1919877497 creator A5003013350 @default.
- W1919877497 creator A5060346495 @default.
- W1919877497 creator A5065203934 @default.
- W1919877497 creator A5080084248 @default.
- W1919877497 date "1999-01-01" @default.
- W1919877497 modified "2023-10-18" @default.
- W1919877497 title "Glial swelling and astrogliosis produce diffusion barriers in the rat spinal cord" @default.
- W1919877497 cites W113694765 @default.
- W1919877497 cites W1558622603 @default.
- W1919877497 cites W1627504329 @default.
- W1919877497 cites W1674335052 @default.
- W1919877497 cites W1864765563 @default.
- W1919877497 cites W1936866440 @default.
- W1919877497 cites W1937363507 @default.
- W1919877497 cites W1941392759 @default.
- W1919877497 cites W1965726367 @default.
- W1919877497 cites W1976522846 @default.
- W1919877497 cites W1977543906 @default.
- W1919877497 cites W1981133890 @default.
- W1919877497 cites W1984036148 @default.
- W1919877497 cites W1987424888 @default.
- W1919877497 cites W1988718920 @default.
- W1919877497 cites W1992836483 @default.
- W1919877497 cites W1994742681 @default.
- W1919877497 cites W1997346304 @default.
- W1919877497 cites W1998678296 @default.
- W1919877497 cites W2002831064 @default.
- W1919877497 cites W2003912106 @default.
- W1919877497 cites W2005896706 @default.
- W1919877497 cites W2016600074 @default.
- W1919877497 cites W2020761570 @default.
- W1919877497 cites W2026247688 @default.
- W1919877497 cites W2033835887 @default.
- W1919877497 cites W203660035 @default.
- W1919877497 cites W2037420975 @default.
- W1919877497 cites W2040740610 @default.
- W1919877497 cites W2042219834 @default.
- W1919877497 cites W2051143596 @default.
- W1919877497 cites W2060338837 @default.
- W1919877497 cites W2062228760 @default.
- W1919877497 cites W2062238583 @default.
- W1919877497 cites W2066485803 @default.
- W1919877497 cites W2067206788 @default.
- W1919877497 cites W2070169065 @default.
- W1919877497 cites W2073758665 @default.
- W1919877497 cites W2075603142 @default.
- W1919877497 cites W2075952655 @default.
- W1919877497 cites W2079399998 @default.
- W1919877497 cites W2082969312 @default.
- W1919877497 cites W2085503685 @default.
- W1919877497 cites W2088125189 @default.
- W1919877497 cites W2089183148 @default.
- W1919877497 cites W2090833562 @default.
- W1919877497 cites W2093194165 @default.
- W1919877497 cites W2097199507 @default.
- W1919877497 cites W2102067114 @default.
- W1919877497 cites W2102313449 @default.
- W1919877497 cites W2105056821 @default.
- W1919877497 cites W2109628321 @default.
- W1919877497 cites W2112848244 @default.
- W1919877497 cites W2114131838 @default.
- W1919877497 cites W2114415505 @default.
- W1919877497 cites W2116836284 @default.
- W1919877497 cites W2133179125 @default.
- W1919877497 cites W2135038519 @default.
- W1919877497 cites W2151861320 @default.
- W1919877497 cites W2205329504 @default.
- W1919877497 cites W2236138476 @default.
- W1919877497 cites W2278090360 @default.
- W1919877497 cites W2341346280 @default.
- W1919877497 cites W2402698977 @default.
- W1919877497 cites W2408194645 @default.
- W1919877497 cites W2410114835 @default.
- W1919877497 cites W2419575906 @default.
- W1919877497 cites W2471054245 @default.
- W1919877497 cites W4249577986 @default.
- W1919877497 cites W841526488 @default.
- W1919877497 doi "https://doi.org/10.1002/(sici)1098-1136(19990101)25:1<56::aid-glia6>3.0.co;2-4" @default.
- W1919877497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9888298" @default.
- W1919877497 hasPublicationYear "1999" @default.
- W1919877497 type Work @default.
- W1919877497 sameAs 1919877497 @default.
- W1919877497 citedByCount "99" @default.
- W1919877497 countsByYear W19198774972012 @default.
- W1919877497 countsByYear W19198774972013 @default.
- W1919877497 countsByYear W19198774972014 @default.
- W1919877497 countsByYear W19198774972016 @default.
- W1919877497 countsByYear W19198774972017 @default.
- W1919877497 countsByYear W19198774972018 @default.
- W1919877497 countsByYear W19198774972023 @default.
- W1919877497 crossrefType "journal-article" @default.
- W1919877497 hasAuthorship W1919877497A5003013350 @default.
- W1919877497 hasAuthorship W1919877497A5060346495 @default.
- W1919877497 hasAuthorship W1919877497A5065203934 @default.
- W1919877497 hasAuthorship W1919877497A5080084248 @default.
- W1919877497 hasConcept C105702510 @default.