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- W191997136 abstract "Publisher Summary This chapter discusses a minimal model of T cell-mediated regulation of the antibody response. The suppression of specific antibody response by T cells is initiated by the antigen-specific T cell factor (TsF), which has been determined to be a product of genes in the I-J subregion of major histocompatibility complex (MHC). It appears that a small number of initial antigen-specific suppressor T cells activate a self-amplifying process, whereby suppression is maintained and augmented. The second pathway of antigen-specific suppression is a direct suppression of some but not all helper T cells. Recently, it has been determined that the antigen specificity of the suppressor T cell and TsF is based on the structure identical or similar to V region of immunoglobulin heavy chains (VH). The purified suppressor T cell as well as TsF has determinants reactive to antibodies against framework structure of VH but not VL. Other investigators have also shown that TsF has idiotypic determinants shared by antibody molecules. Experiments with hybridomas which were made by fusion between suppressor T cells and thymoma cells suggest that antigen specificity and I-J subregion gene products are not always associated. Such a presumably homogeneous TsF from hybridomas also showed a strict genetic restriction with respect to its effect on allogeneic antibody responses. It is now obvious that VH gene products on TsF and TaF determine the antigen specificity of these T cell-derived molecules. I region determinants, on the other hand, would determine the restriction specificity by which T cells can recognize other cell types to interact with." @default.
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- W191997136 date "1980-01-01" @default.
- W191997136 modified "2023-09-27" @default.
- W191997136 title "A MINIMAL MODEL OF T CELL-MEDIATED REGULATION OF THE ANTIBODY RESPONSE" @default.
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- W191997136 doi "https://doi.org/10.1016/b978-0-12-637140-6.50059-0" @default.
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