FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1919984851> ?p ?o ?g. }

• W1919984851 endingPage "3638" @default.
• W1919984851 startingPage "3630" @default.
• W1919984851 abstract "This study investigates the role of CD4+ T cells in host defense against cholera enterotoxin-induced diarrhea. Antitoxin immunoglobulin A formation and gut protection against cholera toxin (CT) following oral immunizations with CT were evaluated in normal mice and mice that had been depleted of CD4+ T cells by in vivo treatment with specific anti-CD4 monoclonal antibodies. Flow cytometer analysis demonstrated that anti-CD4 monoclonal antibody effectively eliminated CD4+ T cells in the spleen, mesenteric lymph nodes, and Peyer's patches. In contrast, lamina propria lymphocytes demonstrated only some decrease in CD4+ T-cell numbers following antibody treatment. However, CD4 expression of individual lamina propria lymphocytes was strongly down-regulated. Depletion of CD4+ T cells performed prior to oral immunization with CT completely inhibited the ability to respond to CT. No antitoxin production, as detected at the single-cell level by the ELISPOT technique, was found in the spleen, mesenteric lymph nodes, or Peyer's patches, nor did we observe serum antitoxin responses in these mice. Control mice demonstrated strong antitoxin responses in all locations following oral immunization with CT. Anti-CD4 antibody treatment also effectively inhibited the antitoxin immunoglobulin A response in the lamina propria to CT as well as blocked the ability to develop gut protection against CT challenge of ligated intestinal loops after oral CT immunization. Thus, in vivo CD4+ T-cell depletion rendered these mice unable to develop protective immunity in the gut following oral immunization with CT. Moreover, CD4+ T-cell depletion effectively inhibited the antitoxin immune response in the gut lamina propria, mesenteric lymph nodes, Peyer's patches, and spleen when performed prior to both priming and booster immunizations with CT. This study clearly demonstrates the requirement of functional CD4+ T cells in the gut immune system for the development of host defense against CT-induced disease. Our data also reinforce the concept of a strong association between gut protection against CT and local production of neutralizing immunoglobulin A antitoxin." @default.
• W1919984851 created "2016-06-24" @default.
• W1919984851 creator A5010629312 @default.
• W1919984851 creator A5034542845 @default.
• W1919984851 creator A5084648920 @default.
• W1919984851 creator A5091062006 @default.
• W1919984851 date "1991-10-01" @default.
• W1919984851 modified "2023-09-27" @default.
• W1919984851 title "Host defense against cholera toxin is strongly CD4+ T cell dependent" @default.
• W1919984851 cites W1501752356 @default.
• W1919984851 cites W1785380284 @default.
• W1919984851 cites W1969992539 @default.
• W1919984851 cites W1976581960 @default.
• W1919984851 cites W1990568245 @default.
• W1919984851 cites W1995138988 @default.
• W1919984851 cites W2009889818 @default.
• W1919984851 cites W2011257622 @default.
• W1919984851 cites W2013167867 @default.
• W1919984851 cites W2013571259 @default.
• W1919984851 cites W2014993834 @default.
• W1919984851 cites W2017335997 @default.
• W1919984851 cites W2034511382 @default.
• W1919984851 cites W2047455387 @default.
• W1919984851 cites W2052356528 @default.
• W1919984851 cites W2055452302 @default.
• W1919984851 cites W2065634204 @default.
• W1919984851 cites W2067193714 @default.
• W1919984851 cites W2078528638 @default.
• W1919984851 cites W2083033324 @default.
• W1919984851 cites W2095345013 @default.
• W1919984851 cites W2111596691 @default.
• W1919984851 cites W2113556355 @default.
• W1919984851 cites W2121791329 @default.
• W1919984851 cites W2129024997 @default.
• W1919984851 cites W2156644464 @default.
• W1919984851 cites W2255569294 @default.
• W1919984851 doi "https://doi.org/10.1128/iai.59.10.3630-3638.1991" @default.
• W1919984851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/258931" @default.
• W1919984851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1910010" @default.
• W1919984851 hasPublicationYear "1991" @default.
• W1919984851 type Work @default.
• W1919984851 sameAs 1919984851 @default.
• W1919984851 citedByCount "50" @default.
• W1919984851 countsByYear W19199848512013 @default.
• W1919984851 countsByYear W19199848512014 @default.
• W1919984851 countsByYear W19199848512017 @default.
• W1919984851 countsByYear W19199848512020 @default.
• W1919984851 crossrefType "journal-article" @default.
• W1919984851 hasAuthorship W1919984851A5010629312 @default.
• W1919984851 hasAuthorship W1919984851A5034542845 @default.
• W1919984851 hasAuthorship W1919984851A5084648920 @default.
• W1919984851 hasAuthorship W1919984851A5091062006 @default.
• W1919984851 hasBestOaLocation W19199848511 @default.
• W1919984851 hasConcept C159654299 @default.
• W1919984851 hasConcept C203014093 @default.
• W1919984851 hasConcept C2776090121 @default.
• W1919984851 hasConcept C2777006276 @default.
• W1919984851 hasConcept C2777047711 @default.
• W1919984851 hasConcept C2777310793 @default.
• W1919984851 hasConcept C2777367657 @default.
• W1919984851 hasConcept C2778643871 @default.
• W1919984851 hasConcept C2778973234 @default.
• W1919984851 hasConcept C2779237934 @default.
• W1919984851 hasConcept C2780931953 @default.
• W1919984851 hasConcept C523546767 @default.
• W1919984851 hasConcept C529295009 @default.
• W1919984851 hasConcept C54355233 @default.
• W1919984851 hasConcept C86803240 @default.
• W1919984851 hasConcept C8891405 @default.
• W1919984851 hasConcept C89423630 @default.
• W1919984851 hasConceptScore W1919984851C159654299 @default.
• W1919984851 hasConceptScore W1919984851C203014093 @default.
• W1919984851 hasConceptScore W1919984851C2776090121 @default.
• W1919984851 hasConceptScore W1919984851C2777006276 @default.
• W1919984851 hasConceptScore W1919984851C2777047711 @default.
• W1919984851 hasConceptScore W1919984851C2777310793 @default.
• W1919984851 hasConceptScore W1919984851C2777367657 @default.
• W1919984851 hasConceptScore W1919984851C2778643871 @default.
• W1919984851 hasConceptScore W1919984851C2778973234 @default.
• W1919984851 hasConceptScore W1919984851C2779237934 @default.
• W1919984851 hasConceptScore W1919984851C2780931953 @default.
• W1919984851 hasConceptScore W1919984851C523546767 @default.
• W1919984851 hasConceptScore W1919984851C529295009 @default.
• W1919984851 hasConceptScore W1919984851C54355233 @default.
• W1919984851 hasConceptScore W1919984851C86803240 @default.
• W1919984851 hasConceptScore W1919984851C8891405 @default.
• W1919984851 hasConceptScore W1919984851C89423630 @default.
• W1919984851 hasIssue "10" @default.
• W1919984851 hasLocation W19199848511 @default.
• W1919984851 hasLocation W19199848512 @default.
• W1919984851 hasLocation W19199848513 @default.
• W1919984851 hasOpenAccess W1919984851 @default.
• W1919984851 hasPrimaryLocation W19199848511 @default.
• W1919984851 hasRelatedWork W1521503145 @default.
• W1919984851 hasRelatedWork W1919984851 @default.
• W1919984851 hasRelatedWork W1971199174 @default.
• W1919984851 hasRelatedWork W2050656853 @default.
• W1919984851 hasRelatedWork W2052356528 @default.

• next