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- W1920009658 abstract "Liver progenitor cells (LPCs) are a promising source of cells to treat liver disease by cell therapy, due to their capability for self-replication and bipotentiality. In order to establish useful culture systems of LPCs and apply them to future clinical therapies, it is necessary to understand their interactions with their microenvironment and especially with the extracellular matrix (ECM). There is considerable evidence from in vivo studies that matrix proteins affect the activation, expansion, migration and differentiation of LPCs, but the information on the role that specific ECMs play in regulating LPCs in vitro is more limited. Nevertheless, current studies suggest that laminin, collagen type III, collagen type IV and hyaluronic acid help to maintain the undifferentiated phenotype of LPCs and promote their proliferation when cultured in media supplemented with growth factors chosen for LPC expansion, whereas collagen type I and fibronectin are generally associated with a differentiated phenotype under the same conditions. Experimental evidence suggests that α6β1 and α5β1 integrins as well as CD44 on the surface of LPCs, and their related downstream signals, are important mediators of interactions between LPCs and the ECM. The interactions of LPCs with the ECM form the focus of this review and the contribution of ECM molecules to strategies for optimizing in vitro LPC cultures for therapeutic applications is discussed." @default.
- W1920009658 created "2016-06-24" @default.
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- W1920009658 date "2012-03-01" @default.
- W1920009658 modified "2023-10-16" @default.
- W1920009658 title "Liver progenitor cell interactions with the extracellular matrix" @default.
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- W1920009658 cites W1561086344 @default.
- W1920009658 cites W1565820371 @default.
- W1920009658 cites W1786861597 @default.
- W1920009658 cites W1964915114 @default.
- W1920009658 cites W1967703106 @default.
- W1920009658 cites W1967818324 @default.
- W1920009658 cites W1975655671 @default.
- W1920009658 cites W1975946365 @default.
- W1920009658 cites W1976183817 @default.
- W1920009658 cites W1977486647 @default.
- W1920009658 cites W1983998639 @default.
- W1920009658 cites W1992736578 @default.
- W1920009658 cites W1997590330 @default.
- W1920009658 cites W1998666537 @default.
- W1920009658 cites W1999887689 @default.
- W1920009658 cites W2005176562 @default.
- W1920009658 cites W2012555937 @default.
- W1920009658 cites W2014484446 @default.
- W1920009658 cites W2014951213 @default.
- W1920009658 cites W2015859327 @default.
- W1920009658 cites W2018089489 @default.
- W1920009658 cites W2024958997 @default.
- W1920009658 cites W2025105528 @default.
- W1920009658 cites W2028471442 @default.
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- W1920009658 cites W2035528570 @default.
- W1920009658 cites W2037632318 @default.
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- W1920009658 cites W2045302214 @default.
- W1920009658 cites W2049875467 @default.
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- W1920009658 cites W2062646130 @default.
- W1920009658 cites W2068107790 @default.
- W1920009658 cites W2069250799 @default.
- W1920009658 cites W2069785796 @default.
- W1920009658 cites W2071716914 @default.
- W1920009658 cites W2077749190 @default.
- W1920009658 cites W2078416937 @default.
- W1920009658 cites W2078775914 @default.
- W1920009658 cites W2080654878 @default.
- W1920009658 cites W2080695431 @default.
- W1920009658 cites W2081898172 @default.
- W1920009658 cites W2083418601 @default.
- W1920009658 cites W2083928202 @default.
- W1920009658 cites W2086336049 @default.
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- W1920009658 cites W2156982040 @default.
- W1920009658 cites W2160905697 @default.
- W1920009658 cites W2169755135 @default.
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- W1920009658 doi "https://doi.org/10.1002/term.1470" @default.
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