Matches in SemOpenAlex for { <https://semopenalex.org/work/W1920042354> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1920042354 endingPage "1760" @default.
- W1920042354 startingPage "1756" @default.
- W1920042354 abstract "To study Moloney murine leukemia virus (M-MulV) proteins associated with the integration of proviral DNA into the host chromosome, we isolated endonuclease activities from purified virion preparations of the wild type and two of its replication mutants. A major endonuclease activity was identified in virions of M-MuLV; the enzyme catalyzed nicks in double-stranded DNA in the presence of either Mn2+ or Mg2+ and was stimulated by ATP. The endonuclease nicked DNA adjacent to all four nucleotides with some preference for G and C. The same enzyme, and in comparable amounts, was isolated from two virus replication mutants: dl2905, deficient in the processing of Pr65gag and Pr200gag-pol, and dl50401, deficient for the virus integration function. In the process of these experiments, the residual reverse transcriptase in mutant dl2905 was shown to be the mature size, implying that the uncleaved precursor lacks enzymatic activity. It appears that the major endonuclease activity found in virions of M-MuLV is not encoded by either the gag or pol genes." @default.
- W1920042354 created "2016-06-24" @default.
- W1920042354 creator A5014890522 @default.
- W1920042354 creator A5042763205 @default.
- W1920042354 date "1987-05-01" @default.
- W1920042354 modified "2023-09-26" @default.
- W1920042354 title "Characterization of endonuclease activities in Moloney murine leukemia virus and its replication-defective mutants" @default.
- W1920042354 cites W1517900121 @default.
- W1920042354 cites W1528099054 @default.
- W1920042354 cites W1550792637 @default.
- W1920042354 cites W1576168684 @default.
- W1920042354 cites W1602347777 @default.
- W1920042354 cites W1764381406 @default.
- W1920042354 cites W1906261109 @default.
- W1920042354 cites W1997110527 @default.
- W1920042354 cites W2002907404 @default.
- W1920042354 cites W2014568295 @default.
- W1920042354 cites W2015809730 @default.
- W1920042354 cites W2025260589 @default.
- W1920042354 cites W2031701611 @default.
- W1920042354 cites W2035042125 @default.
- W1920042354 cites W2036334545 @default.
- W1920042354 cites W2055541752 @default.
- W1920042354 cites W2065979160 @default.
- W1920042354 cites W2068066098 @default.
- W1920042354 cites W2142638152 @default.
- W1920042354 doi "https://doi.org/10.1128/jvi.61.5.1756-1760.1987" @default.
- W1920042354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/254172" @default.
- W1920042354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3033306" @default.
- W1920042354 hasPublicationYear "1987" @default.
- W1920042354 type Work @default.
- W1920042354 sameAs 1920042354 @default.
- W1920042354 citedByCount "23" @default.
- W1920042354 crossrefType "journal-article" @default.
- W1920042354 hasAuthorship W1920042354A5014890522 @default.
- W1920042354 hasAuthorship W1920042354A5042763205 @default.
- W1920042354 hasBestOaLocation W19200423541 @default.
- W1920042354 hasConcept C104317684 @default.
- W1920042354 hasConcept C128319531 @default.
- W1920042354 hasConcept C140704245 @default.
- W1920042354 hasConcept C143065580 @default.
- W1920042354 hasConcept C153911025 @default.
- W1920042354 hasConcept C156719811 @default.
- W1920042354 hasConcept C159047783 @default.
- W1920042354 hasConcept C2522874641 @default.
- W1920042354 hasConcept C2777028655 @default.
- W1920042354 hasConcept C2779562191 @default.
- W1920042354 hasConcept C552990157 @default.
- W1920042354 hasConcept C55493867 @default.
- W1920042354 hasConcept C67705224 @default.
- W1920042354 hasConcept C73573662 @default.
- W1920042354 hasConcept C86803240 @default.
- W1920042354 hasConceptScore W1920042354C104317684 @default.
- W1920042354 hasConceptScore W1920042354C128319531 @default.
- W1920042354 hasConceptScore W1920042354C140704245 @default.
- W1920042354 hasConceptScore W1920042354C143065580 @default.
- W1920042354 hasConceptScore W1920042354C153911025 @default.
- W1920042354 hasConceptScore W1920042354C156719811 @default.
- W1920042354 hasConceptScore W1920042354C159047783 @default.
- W1920042354 hasConceptScore W1920042354C2522874641 @default.
- W1920042354 hasConceptScore W1920042354C2777028655 @default.
- W1920042354 hasConceptScore W1920042354C2779562191 @default.
- W1920042354 hasConceptScore W1920042354C552990157 @default.
- W1920042354 hasConceptScore W1920042354C55493867 @default.
- W1920042354 hasConceptScore W1920042354C67705224 @default.
- W1920042354 hasConceptScore W1920042354C73573662 @default.
- W1920042354 hasConceptScore W1920042354C86803240 @default.
- W1920042354 hasIssue "5" @default.
- W1920042354 hasLocation W19200423541 @default.
- W1920042354 hasLocation W19200423542 @default.
- W1920042354 hasLocation W19200423543 @default.
- W1920042354 hasLocation W19200423544 @default.
- W1920042354 hasLocation W19200423545 @default.
- W1920042354 hasOpenAccess W1920042354 @default.
- W1920042354 hasPrimaryLocation W19200423541 @default.
- W1920042354 hasRelatedWork W1810181491 @default.
- W1920042354 hasRelatedWork W2042679985 @default.
- W1920042354 hasRelatedWork W2103264367 @default.
- W1920042354 hasRelatedWork W2116464980 @default.
- W1920042354 hasRelatedWork W2124259207 @default.
- W1920042354 hasRelatedWork W2124927935 @default.
- W1920042354 hasRelatedWork W2156412716 @default.
- W1920042354 hasRelatedWork W2163442683 @default.
- W1920042354 hasRelatedWork W2186607924 @default.
- W1920042354 hasRelatedWork W77186614 @default.
- W1920042354 hasVolume "61" @default.
- W1920042354 isParatext "false" @default.
- W1920042354 isRetracted "false" @default.
- W1920042354 magId "1920042354" @default.
- W1920042354 workType "article" @default.