FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1920075805> ?p ?o ?g. }

• W1920075805 endingPage "4882" @default.
• W1920075805 startingPage "4878" @default.
• W1920075805 abstract "Proinflammatory cytokines have been demonstrated to play a crucial role in the pathogenesis of Crohn's disease. Among those cytokines, strong expression of IL-6 has been repeatedly demonstrated. To examine the role for IL-6 in the pathogenesis of Crohn's disease, we introduced anti-IL-6R mAb to a murine model of colitis. Colitis was induced in C.B-17-scid mice transferred with CD45RBhigh CD4+ T cells from BALB/c mice. Anti-IL-6R mAb or rat IgG was administered weekly after T cell transfer. ICAM-1 and VCAM-1 expression were analyzed by immunohistochemistry. Colonic cytokine expression was determined by RT-PCR. Mice treated with mAb showed normal growth, whereas controls lost weight. The average colitis score was 0.64 for mAb-treated mice and 1.80 for controls. T cell expansion in treated mice was less remarkable than in the controls. Colonic ICAM-1 and VCAM-1 expression were markedly suppressed by mAb. IFN-gamma, TNF-alpha, and IL-1beta mRNA were reduced by the treatment. The results presented here show a crucial role for IL-6 in the pathogenesis of murine colitis and suggest a therapeutic potential of anti-IL-6R mAb for treatment of human Crohn's disease." @default.
• W1920075805 created "2016-06-24" @default.
• W1920075805 creator A5014964663 @default.
• W1920075805 creator A5021463605 @default.
• W1920075805 creator A5057375107 @default.
• W1920075805 creator A5090226154 @default.
• W1920075805 date "2000-05-01" @default.
• W1920075805 modified "2023-10-18" @default.
• W1920075805 title "IL-6 Is Required for the Development of Th1 Cell-Mediated Murine Colitis" @default.
• W1920075805 cites W1484048267 @default.
• W1920075805 cites W1526621387 @default.
• W1920075805 cites W1570714750 @default.
• W1920075805 cites W1723158139 @default.
• W1920075805 cites W1777081626 @default.
• W1920075805 cites W1929074972 @default.
• W1920075805 cites W1946093640 @default.
• W1920075805 cites W1958296118 @default.
• W1920075805 cites W1971119469 @default.
• W1920075805 cites W2006708761 @default.
• W1920075805 cites W2009643606 @default.
• W1920075805 cites W2032848182 @default.
• W1920075805 cites W2036503881 @default.
• W1920075805 cites W2062528530 @default.
• W1920075805 cites W2085451664 @default.
• W1920075805 cites W2118202213 @default.
• W1920075805 cites W2135575955 @default.
• W1920075805 cites W2141679700 @default.
• W1920075805 cites W2155125073 @default.
• W1920075805 doi "https://doi.org/10.4049/jimmunol.164.9.4878" @default.
• W1920075805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10779797" @default.
• W1920075805 hasPublicationYear "2000" @default.
• W1920075805 type Work @default.
• W1920075805 sameAs 1920075805 @default.
• W1920075805 citedByCount "382" @default.
• W1920075805 countsByYear W19200758052012 @default.
• W1920075805 countsByYear W19200758052013 @default.
• W1920075805 countsByYear W19200758052014 @default.
• W1920075805 countsByYear W19200758052015 @default.
• W1920075805 countsByYear W19200758052016 @default.
• W1920075805 countsByYear W19200758052017 @default.
• W1920075805 countsByYear W19200758052018 @default.
• W1920075805 countsByYear W19200758052019 @default.
• W1920075805 countsByYear W19200758052020 @default.
• W1920075805 countsByYear W19200758052021 @default.
• W1920075805 countsByYear W19200758052022 @default.
• W1920075805 countsByYear W19200758052023 @default.
• W1920075805 crossrefType "journal-article" @default.
• W1920075805 hasAuthorship W1920075805A5014964663 @default.
• W1920075805 hasAuthorship W1920075805A5021463605 @default.
• W1920075805 hasAuthorship W1920075805A5057375107 @default.
• W1920075805 hasAuthorship W1920075805A5090226154 @default.
• W1920075805 hasBestOaLocation W19200758051 @default.
• W1920075805 hasConcept C142724271 @default.
• W1920075805 hasConcept C159654299 @default.
• W1920075805 hasConcept C164027704 @default.
• W1920075805 hasConcept C17991360 @default.
• W1920075805 hasConcept C203014093 @default.
• W1920075805 hasConcept C204232928 @default.
• W1920075805 hasConcept C2775862500 @default.
• W1920075805 hasConcept C2776090121 @default.
• W1920075805 hasConcept C2776914184 @default.
• W1920075805 hasConcept C2778260677 @default.
• W1920075805 hasConcept C2778690821 @default.
• W1920075805 hasConcept C2779134260 @default.
• W1920075805 hasConcept C2780942790 @default.
• W1920075805 hasConcept C542903549 @default.
• W1920075805 hasConcept C71924100 @default.
• W1920075805 hasConcept C86803240 @default.
• W1920075805 hasConcept C8891405 @default.
• W1920075805 hasConceptScore W1920075805C142724271 @default.
• W1920075805 hasConceptScore W1920075805C159654299 @default.
• W1920075805 hasConceptScore W1920075805C164027704 @default.
• W1920075805 hasConceptScore W1920075805C17991360 @default.
• W1920075805 hasConceptScore W1920075805C203014093 @default.
• W1920075805 hasConceptScore W1920075805C204232928 @default.
• W1920075805 hasConceptScore W1920075805C2775862500 @default.
• W1920075805 hasConceptScore W1920075805C2776090121 @default.
• W1920075805 hasConceptScore W1920075805C2776914184 @default.
• W1920075805 hasConceptScore W1920075805C2778260677 @default.
• W1920075805 hasConceptScore W1920075805C2778690821 @default.
• W1920075805 hasConceptScore W1920075805C2779134260 @default.
• W1920075805 hasConceptScore W1920075805C2780942790 @default.
• W1920075805 hasConceptScore W1920075805C542903549 @default.
• W1920075805 hasConceptScore W1920075805C71924100 @default.
• W1920075805 hasConceptScore W1920075805C86803240 @default.
• W1920075805 hasConceptScore W1920075805C8891405 @default.
• W1920075805 hasIssue "9" @default.
• W1920075805 hasLocation W19200758051 @default.
• W1920075805 hasLocation W19200758052 @default.
• W1920075805 hasOpenAccess W1920075805 @default.
• W1920075805 hasPrimaryLocation W19200758051 @default.
• W1920075805 hasRelatedWork W1509080832 @default.
• W1920075805 hasRelatedWork W1992848314 @default.
• W1920075805 hasRelatedWork W2015667478 @default.
• W1920075805 hasRelatedWork W2306829214 @default.
• W1920075805 hasRelatedWork W2392126385 @default.
• W1920075805 hasRelatedWork W2416795054 @default.
• W1920075805 hasRelatedWork W2750722062 @default.

• next