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• W1920409078 abstract "Emergence of multidrug-resistant (MDR) strains of Helicobacter pylori is a global health concern. This study was aimed to determine the frequency of MDR H. pylori strains in Iran. H. pylori isolates were obtained from cultured gastric biopsy samples on selective culture media after their characterization by PCR and conventional biochemical methods. The minimal inhibitory concentrations of rifampicin, ciprofloxacin, levofloxacin, ampicillin, clarithromycin, erythromycin, metronidazole, and tetracycline were determined for 111 strains that were isolated from 197 dyspeptic patients by the agar dilution method. The primary resistance rates were 61.3% (68/111) for metronidazole, 15.3% (17/111) for ampicillin, and 14.4% (16/111) for rifampicin. Resistance rates for other antimicrobials were as follows: macrolides (erythromycin or clarithromycin) 32.4% (36/111) and quinolones (levofloxacin or ciprofloxacin) 30.6% (34/111). Among the resistant strains, the rates of double and multiple drug resistance phenotypes were 22.6% (19/84) and 34.5% (29/84), respectively. The quadruple drug resistance phenotype encompasses 37.9% of the MDR strains, of which 90% of them was resistant to metronidazole. In conclusion, these results showed a high frequency of MDR phenotypes among the studied H. pylori strains in Iran. The eradication of the H. pylori strains presenting high resistance rates to macrolides, fluoroquinolones, or metronidazole could be achieved by approved tetracycline- or amoxicillin-containing regimens as alternative regimens to standard triple therapy." @default.
• W1920409078 created "2016-06-24" @default.
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• W1920409078 date "2015-02-01" @default.
• W1920409078 modified "2023-10-18" @default.
• W1920409078 title "Prevalence of Multiple Drug-Resistant <i>Helicobacter pylori</i> Strains Among Patients with Different Gastric Disorders in Iran" @default.
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• W1920409078 doi "https://doi.org/10.1089/mdr.2014.0081" @default.
• W1920409078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25303151" @default.
• W1920409078 hasPublicationYear "2015" @default.
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