Matches in SemOpenAlex for { <https://semopenalex.org/work/W1920429098> ?p ?o ?g. }
- W1920429098 endingPage "18506" @default.
- W1920429098 startingPage "18474" @default.
- W1920429098 abstract "Serotonin (5-HT) is a monoamine neurotransmitter that plays an important role in physiological functions. 5-HT has been implicated in sleep, feeding, sexual behavior, temperature regulation, pain, and cognition as well as in pathological states including disorders connected to mood, anxiety, psychosis and pain. 5-HT1A receptors have for a long time been considered as an interesting target for the action of antidepressant drugs. It was postulated that postsynaptic 5-HT1A agonists could form a new class of antidepressant drugs, and mixed 5-HT1A receptor ligands/serotonin transporter (SERT) inhibitors seem to possess an interesting pharmacological profile. It should, however, be noted that 5-HT1A receptors can activate several different biochemical pathways and signal through both G protein-dependent and G protein-independent pathways. The variables that affect the multiplicity of 5-HT1A receptor signaling pathways would thus result from the summation of effects specific to the host cell milieu. Moreover, receptor trafficking appears different at pre- and postsynaptic sites. It should also be noted that the 5-HT1A receptor cooperates with other signal transduction systems (like the 5-HT1B or 5-HT2A/2B/2C receptors, the GABAergic and the glutaminergic systems), which also contribute to its antidepressant and/or anxiolytic activity. Thus identifying brain specific molecular targets for 5-HT1A receptor ligands may result in a better targeting, raising a hope for more effective medicines for various pathologies." @default.
- W1920429098 created "2016-06-24" @default.
- W1920429098 creator A5020144569 @default.
- W1920429098 creator A5025399512 @default.
- W1920429098 creator A5069966276 @default.
- W1920429098 creator A5082517862 @default.
- W1920429098 date "2015-08-07" @default.
- W1920429098 modified "2023-10-01" @default.
- W1920429098 title "Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands" @default.
- W1920429098 cites W154356911 @default.
- W1920429098 cites W1552407238 @default.
- W1920429098 cites W1588173517 @default.
- W1920429098 cites W1758789982 @default.
- W1920429098 cites W1795694346 @default.
- W1920429098 cites W1798489567 @default.
- W1920429098 cites W1826950194 @default.
- W1920429098 cites W1828538530 @default.
- W1920429098 cites W1861512592 @default.
- W1920429098 cites W1867927889 @default.
- W1920429098 cites W1928975456 @default.
- W1920429098 cites W1929691281 @default.
- W1920429098 cites W1963600261 @default.
- W1920429098 cites W1965390333 @default.
- W1920429098 cites W1966173192 @default.
- W1920429098 cites W1968912840 @default.
- W1920429098 cites W1970160259 @default.
- W1920429098 cites W1971954112 @default.
- W1920429098 cites W1972886279 @default.
- W1920429098 cites W1973486104 @default.
- W1920429098 cites W1974369164 @default.
- W1920429098 cites W1974776346 @default.
- W1920429098 cites W1979257727 @default.
- W1920429098 cites W1980413997 @default.
- W1920429098 cites W1983311178 @default.
- W1920429098 cites W1984815383 @default.
- W1920429098 cites W1987299915 @default.
- W1920429098 cites W1987514922 @default.
- W1920429098 cites W1987837679 @default.
- W1920429098 cites W1989436490 @default.
- W1920429098 cites W1990547035 @default.
- W1920429098 cites W1991461979 @default.
- W1920429098 cites W1991838929 @default.
- W1920429098 cites W1992046617 @default.
- W1920429098 cites W1993796910 @default.
- W1920429098 cites W1994543595 @default.
- W1920429098 cites W1994637967 @default.
- W1920429098 cites W1994702289 @default.
- W1920429098 cites W1996694057 @default.
- W1920429098 cites W1997091817 @default.
- W1920429098 cites W1997521545 @default.
- W1920429098 cites W1997976229 @default.
- W1920429098 cites W1998088135 @default.
- W1920429098 cites W1998772348 @default.
- W1920429098 cites W1998780198 @default.
- W1920429098 cites W1999081857 @default.
- W1920429098 cites W2000224259 @default.
- W1920429098 cites W2001287327 @default.
- W1920429098 cites W2003982930 @default.
- W1920429098 cites W2004019168 @default.
- W1920429098 cites W2004725260 @default.
- W1920429098 cites W2004838884 @default.
- W1920429098 cites W2006460397 @default.
- W1920429098 cites W2007032888 @default.
- W1920429098 cites W2007537092 @default.
- W1920429098 cites W2007612689 @default.
- W1920429098 cites W2011829021 @default.
- W1920429098 cites W2012098181 @default.
- W1920429098 cites W2012250334 @default.
- W1920429098 cites W2012975576 @default.
- W1920429098 cites W2013507314 @default.
- W1920429098 cites W2013750906 @default.
- W1920429098 cites W2014001501 @default.
- W1920429098 cites W2016400347 @default.
- W1920429098 cites W2017221228 @default.
- W1920429098 cites W2019803381 @default.
- W1920429098 cites W2022468859 @default.
- W1920429098 cites W2022658303 @default.
- W1920429098 cites W2023753446 @default.
- W1920429098 cites W2023854352 @default.
- W1920429098 cites W2025682675 @default.
- W1920429098 cites W2028524283 @default.
- W1920429098 cites W2029329379 @default.
- W1920429098 cites W2031733304 @default.
- W1920429098 cites W2033495092 @default.
- W1920429098 cites W2034742511 @default.
- W1920429098 cites W2034961437 @default.
- W1920429098 cites W2036157193 @default.
- W1920429098 cites W2038989561 @default.
- W1920429098 cites W2039566040 @default.
- W1920429098 cites W2040911489 @default.
- W1920429098 cites W2042580038 @default.
- W1920429098 cites W2044821770 @default.
- W1920429098 cites W2046216255 @default.
- W1920429098 cites W2047129003 @default.
- W1920429098 cites W2048283236 @default.
- W1920429098 cites W2050339343 @default.
- W1920429098 cites W2050347424 @default.
- W1920429098 cites W2051531767 @default.