Matches in SemOpenAlex for { <https://semopenalex.org/work/W1920452455> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1920452455 endingPage "47" @default.
- W1920452455 startingPage "535" @default.
- W1920452455 abstract "Threo - dl -methylphenidate- 14 C·HCl (MEPH- 14 C·HCl) was found to be extensively metabolized in man, dog, rat and mouse. Pronounced species differences in the metabolism of the drug were found. In human subjects, plasma levels of MEPH- 14 C were found always to be much higher after i.v. than after oral administration. After oral administration, 50 and 90% of the 14 C was excreted in urine in 8 and 48 hours, respectively. This suggests essentially complete absorption of MEPH. The main urinary metabolite was the deesterified product, ritalinic acid (RA), accounting for 80% of the dose. Upon i.v. administration of MEPH- 14 C·HCl to dogs, 50 to 60% of the radioactivity was excreted in 7-hour urine. The major metabolites in dog urine were RA and threo - dl -2-phenyl-2-(29-piperidyl-69-one) acetic acid (oxo-RA). In rats, both after i.p. and oral administration of MEPH- 14 C·HCl, 50 to 60% of the 14 C was eliminated in urine and 30 to 40% in feces within 48 hours. Significant biliary excretion of 14 C (25-30% in 12 hours) was found in bile-cannulated rats. The major metabolites in rat urine besides RA were threo - dl -2-( p -hydroxyphenyl)-2-(29-piperidyl) acetic acid ( p -OH RA), its methyl ester ( p -OH MEPH)and the glucuronide conjugate of p -OH RA. The locomotor activity of MEPH, certain metabolites and N-acetyl MEPH was studied in mice." @default.
- W1920452455 created "2016-06-24" @default.
- W1920452455 creator A5021988962 @default.
- W1920452455 creator A5030235579 @default.
- W1920452455 creator A5034961991 @default.
- W1920452455 creator A5058790605 @default.
- W1920452455 creator A5065646513 @default.
- W1920452455 creator A5071664777 @default.
- W1920452455 creator A5090664980 @default.
- W1920452455 date "1974-12-01" @default.
- W1920452455 modified "2023-09-26" @default.
- W1920452455 title "Metabolism and disposition of methylphenidate-14C: studies in man and animals." @default.
- W1920452455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4473537" @default.
- W1920452455 hasPublicationYear "1974" @default.
- W1920452455 type Work @default.
- W1920452455 sameAs 1920452455 @default.
- W1920452455 citedByCount "58" @default.
- W1920452455 countsByYear W19204524552012 @default.
- W1920452455 countsByYear W19204524552013 @default.
- W1920452455 countsByYear W19204524552014 @default.
- W1920452455 countsByYear W19204524552015 @default.
- W1920452455 countsByYear W19204524552016 @default.
- W1920452455 countsByYear W19204524552019 @default.
- W1920452455 countsByYear W19204524552022 @default.
- W1920452455 crossrefType "journal-article" @default.
- W1920452455 hasAuthorship W1920452455A5021988962 @default.
- W1920452455 hasAuthorship W1920452455A5030235579 @default.
- W1920452455 hasAuthorship W1920452455A5034961991 @default.
- W1920452455 hasAuthorship W1920452455A5058790605 @default.
- W1920452455 hasAuthorship W1920452455A5065646513 @default.
- W1920452455 hasAuthorship W1920452455A5071664777 @default.
- W1920452455 hasAuthorship W1920452455A5090664980 @default.
- W1920452455 hasConcept C10146269 @default.
- W1920452455 hasConcept C112705442 @default.
- W1920452455 hasConcept C126322002 @default.
- W1920452455 hasConcept C185592680 @default.
- W1920452455 hasConcept C2776673659 @default.
- W1920452455 hasConcept C2777056448 @default.
- W1920452455 hasConcept C2777477808 @default.
- W1920452455 hasConcept C2779186261 @default.
- W1920452455 hasConcept C2780026642 @default.
- W1920452455 hasConcept C55493867 @default.
- W1920452455 hasConcept C62231903 @default.
- W1920452455 hasConcept C71924100 @default.
- W1920452455 hasConcept C77411442 @default.
- W1920452455 hasConcept C98274493 @default.
- W1920452455 hasConceptScore W1920452455C10146269 @default.
- W1920452455 hasConceptScore W1920452455C112705442 @default.
- W1920452455 hasConceptScore W1920452455C126322002 @default.
- W1920452455 hasConceptScore W1920452455C185592680 @default.
- W1920452455 hasConceptScore W1920452455C2776673659 @default.
- W1920452455 hasConceptScore W1920452455C2777056448 @default.
- W1920452455 hasConceptScore W1920452455C2777477808 @default.
- W1920452455 hasConceptScore W1920452455C2779186261 @default.
- W1920452455 hasConceptScore W1920452455C2780026642 @default.
- W1920452455 hasConceptScore W1920452455C55493867 @default.
- W1920452455 hasConceptScore W1920452455C62231903 @default.
- W1920452455 hasConceptScore W1920452455C71924100 @default.
- W1920452455 hasConceptScore W1920452455C77411442 @default.
- W1920452455 hasConceptScore W1920452455C98274493 @default.
- W1920452455 hasIssue "3" @default.
- W1920452455 hasLocation W19204524551 @default.
- W1920452455 hasOpenAccess W1920452455 @default.
- W1920452455 hasPrimaryLocation W19204524551 @default.
- W1920452455 hasRelatedWork W1992584842 @default.
- W1920452455 hasRelatedWork W2055491021 @default.
- W1920452455 hasRelatedWork W2060949085 @default.
- W1920452455 hasRelatedWork W2111080840 @default.
- W1920452455 hasRelatedWork W2117184058 @default.
- W1920452455 hasRelatedWork W2313184302 @default.
- W1920452455 hasRelatedWork W2419698552 @default.
- W1920452455 hasRelatedWork W2746927775 @default.
- W1920452455 hasRelatedWork W2899084033 @default.
- W1920452455 hasRelatedWork W2989591960 @default.
- W1920452455 hasVolume "191" @default.
- W1920452455 isParatext "false" @default.
- W1920452455 isRetracted "false" @default.
- W1920452455 magId "1920452455" @default.
- W1920452455 workType "article" @default.