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• W1920478732 endingPage "2013" @default.
• W1920478732 startingPage "2002" @default.
• W1920478732 abstract "The minichromosome maintenance complex (MCM) proteins are required for processive DNA replication and are a target of S-phase checkpoints. The eukaryotic MCM complex consists of six proteins (MCM2–7) that form a heterohexameric ring with DNA helicase activity, which is loaded on chromatin to form the pre-replication complex. Upon entry in S phase, the helicase is activated and opens the DNA duplex to recruit DNA polymerases at the replication fork. The MCM complex thus plays a crucial role during DNA replication, but recent work suggests that MCM proteins could also be involved in DNA repair. Here, we employed a combination of stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics with immunoprecipitation of green fluorescent protein-tagged fusion proteins to identify proteins interacting with the MCM complex, and quantify changes in interactions in response to DNA damage. Interestingly, the MCM complex showed very dynamic changes in interaction with proteins such as Importin7, the histone chaperone ASF1, and the Chromodomain helicase DNA binding protein 3 (CHD3) following DNA damage. These changes in interactions were accompanied by an increase in phosphorylation and ubiquitination on specific sites on the MCM proteins and an increase in the co-localization of the MCM complex with γ-H2AX, confirming the recruitment of these proteins to sites of DNA damage. In summary, our data indicate that the MCM proteins is involved in chromatin remodeling in response to DNA damage." @default.
• W1920478732 created "2016-06-24" @default.
• W1920478732 creator A5008089179 @default.
• W1920478732 creator A5041114334 @default.
• W1920478732 creator A5045306174 @default.
• W1920478732 creator A5056050850 @default.
• W1920478732 date "2015-07-01" @default.
• W1920478732 modified "2023-10-12" @default.
• W1920478732 title "Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage*" @default.
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• W1920478732 doi "https://doi.org/10.1074/mcp.m115.048991" @default.
• W1920478732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4587322" @default.
• W1920478732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25963833" @default.
• W1920478732 hasPublicationYear "2015" @default.
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