Matches in SemOpenAlex for { <https://semopenalex.org/work/W1920582783> ?p ?o ?g. }
- W1920582783 endingPage "2682" @default.
- W1920582783 startingPage "2673" @default.
- W1920582783 abstract "It is generally agreed that, above the level of the 30 nm fibre, eukaryotic chromatin is constrained into loops, but there is disagreement about the nature of the substructure that serves to anchor loops and the DNA sequences that act as the attachment sites. This problem may stem from the very different methods that all purport to separate loop and attached DNAs. We have tested ideas about how the genome is arranged into loops by analysing the average loop size over different cytologically resolvable regions of human chromosomes using fluorescence in situ hybridisation with loop and attached DNA fractions. Variations in average loop size, along and between chromosomes, measurable at this level of resolution were small but significant and were dependent on the extraction method. This emphasises the fundamental differences between the nuclear substructure probed by different protocols. DNA attached to the nuclear 'scaffold' or 'matrix' hybridises preferentially to gene-poor regions of the genome (G-bands). Conversely, fractions attached to the nuclear 'skeleton' hybridise preferentially to gene-rich R-bands and sites of high levels of transcription. The inactive X chromosome has a deficit of associations with the nuclear skeleton but not with the matrix or scaffold. A large excess of attached sequences is found at some sites of constitutive heterochromatin, but not at centromeres." @default.
- W1920582783 created "2016-06-24" @default.
- W1920582783 creator A5015101570 @default.
- W1920582783 creator A5035473961 @default.
- W1920582783 creator A5076700359 @default.
- W1920582783 creator A5082453156 @default.
- W1920582783 date "1997-11-01" @default.
- W1920582783 modified "2023-10-09" @default.
- W1920582783 title "Scaffold attachments within the human genome" @default.
- W1920582783 cites W1517336242 @default.
- W1920582783 cites W1552353351 @default.
- W1920582783 cites W1874943101 @default.
- W1920582783 cites W1965026484 @default.
- W1920582783 cites W1968046362 @default.
- W1920582783 cites W1968472660 @default.
- W1920582783 cites W1971792543 @default.
- W1920582783 cites W1981661959 @default.
- W1920582783 cites W1999748402 @default.
- W1920582783 cites W2000939708 @default.
- W1920582783 cites W2009059845 @default.
- W1920582783 cites W2019155756 @default.
- W1920582783 cites W2022002003 @default.
- W1920582783 cites W2038065379 @default.
- W1920582783 cites W2038151125 @default.
- W1920582783 cites W2038283767 @default.
- W1920582783 cites W2039128321 @default.
- W1920582783 cites W2041517407 @default.
- W1920582783 cites W2043734426 @default.
- W1920582783 cites W2055916581 @default.
- W1920582783 cites W2058311130 @default.
- W1920582783 cites W2059991470 @default.
- W1920582783 cites W2068822634 @default.
- W1920582783 cites W2078816032 @default.
- W1920582783 cites W2083584357 @default.
- W1920582783 cites W2096277721 @default.
- W1920582783 cites W2115512131 @default.
- W1920582783 cites W2127301911 @default.
- W1920582783 cites W2138576404 @default.
- W1920582783 cites W2144915067 @default.
- W1920582783 cites W2162633623 @default.
- W1920582783 cites W2165409131 @default.
- W1920582783 cites W2169716899 @default.
- W1920582783 cites W2220955715 @default.
- W1920582783 cites W2414453285 @default.
- W1920582783 cites W39451727 @default.
- W1920582783 cites W4322384960 @default.
- W1920582783 doi "https://doi.org/10.1242/jcs.110.21.2673" @default.
- W1920582783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9427385" @default.
- W1920582783 hasPublicationYear "1997" @default.
- W1920582783 type Work @default.
- W1920582783 sameAs 1920582783 @default.
- W1920582783 citedByCount "45" @default.
- W1920582783 countsByYear W19205827832012 @default.
- W1920582783 countsByYear W19205827832013 @default.
- W1920582783 countsByYear W19205827832014 @default.
- W1920582783 countsByYear W19205827832017 @default.
- W1920582783 countsByYear W19205827832019 @default.
- W1920582783 countsByYear W19205827832021 @default.
- W1920582783 crossrefType "journal-article" @default.
- W1920582783 hasAuthorship W1920582783A5015101570 @default.
- W1920582783 hasAuthorship W1920582783A5035473961 @default.
- W1920582783 hasAuthorship W1920582783A5076700359 @default.
- W1920582783 hasAuthorship W1920582783A5082453156 @default.
- W1920582783 hasConcept C103435993 @default.
- W1920582783 hasConcept C104317684 @default.
- W1920582783 hasConcept C105686024 @default.
- W1920582783 hasConcept C127413603 @default.
- W1920582783 hasConcept C140367098 @default.
- W1920582783 hasConcept C141231307 @default.
- W1920582783 hasConcept C153911025 @default.
- W1920582783 hasConcept C167227067 @default.
- W1920582783 hasConcept C169802333 @default.
- W1920582783 hasConcept C197077220 @default.
- W1920582783 hasConcept C30481170 @default.
- W1920582783 hasConcept C54355233 @default.
- W1920582783 hasConcept C552990157 @default.
- W1920582783 hasConcept C56262557 @default.
- W1920582783 hasConcept C63491729 @default.
- W1920582783 hasConcept C66938386 @default.
- W1920582783 hasConcept C72391661 @default.
- W1920582783 hasConcept C83640560 @default.
- W1920582783 hasConcept C86803240 @default.
- W1920582783 hasConcept C95444343 @default.
- W1920582783 hasConcept C99679407 @default.
- W1920582783 hasConceptScore W1920582783C103435993 @default.
- W1920582783 hasConceptScore W1920582783C104317684 @default.
- W1920582783 hasConceptScore W1920582783C105686024 @default.
- W1920582783 hasConceptScore W1920582783C127413603 @default.
- W1920582783 hasConceptScore W1920582783C140367098 @default.
- W1920582783 hasConceptScore W1920582783C141231307 @default.
- W1920582783 hasConceptScore W1920582783C153911025 @default.
- W1920582783 hasConceptScore W1920582783C167227067 @default.
- W1920582783 hasConceptScore W1920582783C169802333 @default.
- W1920582783 hasConceptScore W1920582783C197077220 @default.
- W1920582783 hasConceptScore W1920582783C30481170 @default.
- W1920582783 hasConceptScore W1920582783C54355233 @default.
- W1920582783 hasConceptScore W1920582783C552990157 @default.
- W1920582783 hasConceptScore W1920582783C56262557 @default.