FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1920604003> ?p ?o ?g. }

• W1920604003 endingPage "265" @default.
• W1920604003 startingPage "265" @default.
• W1920604003 abstract "Studies suggest pioglitazone use may increase risk of cancers.To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers.Cohort and nested case-control analyses among persons with diabetes. A bladder cancer cohort followed 193,099 persons aged 40 years or older in 1997-2002 until December 2012; 464 case patients and 464 matched controls were surveyed about additional confounders. A cohort analysis of 10 additional cancers included 236,507 persons aged 40 years or older in 1997-2005 and followed until June 2012. Cohorts were from Kaiser Permanente Northern California.Ever use, duration, cumulative dose, and time since initiation of pioglitazone as time dependent.Incident cancer, including bladder, prostate, female breast, lung/bronchus, endometrial, colon, non-Hodgkin lymphoma, pancreas, kidney/renal pelvis, rectum, and melanoma.Among 193,099 persons in the bladder cancer cohort, 34,181 (18%) received pioglitazone (median duration, 2.8 years; range, 0.2-13.2 years) and 1261 had incident bladder cancer. Crude incidences of bladder cancer in pioglitazone users and nonusers were 89.8 and 75.9 per 100,000 person-years, respectively. Ever use of pioglitazone was not associated with bladder cancer risk (adjusted hazard ratio [HR], 1.06; 95% CI, 0.89-1.26). Results were similar in case-control analyses (pioglitazone use: 19.6% among case patients and 17.5% among controls; adjusted odds ratio, 1.18; 95% CI, 0.78-1.80). In adjusted analyses, there was no association with 8 of the 10 additional cancers; ever use of pioglitazone was associated with increased risk of prostate cancer (HR, 1.13; 95% CI, 1.02-1.26) and pancreatic cancer (HR, 1.41; 95% CI, 1.16-1.71). Crude incidences of prostate and pancreatic cancer in pioglitazone users vs nonusers were 453.3 vs 449.3 and 81.1 vs 48.4 per 100,000 person-years, respectively. No clear patterns of risk for any cancer were observed for time since initiation, duration, or dose.Pioglitazone use was not associated with a statistically significant increased risk of bladder cancer, although an increased risk, as previously observed, could not be excluded. The increased prostate and pancreatic cancer risks associated with ever use of pioglitazone merit further investigation to assess whether they are causal or are due to chance, residual confounding, or reverse causality." @default.
• W1920604003 created "2016-06-24" @default.
• W1920604003 creator A5001126649 @default.
• W1920604003 creator A5001652121 @default.
• W1920604003 creator A5023847764 @default.
• W1920604003 creator A5024575747 @default.
• W1920604003 creator A5029294320 @default.
• W1920604003 creator A5035439869 @default.
• W1920604003 creator A5041936168 @default.
• W1920604003 creator A5047557865 @default.
• W1920604003 creator A5051151649 @default.
• W1920604003 creator A5052785465 @default.
• W1920604003 creator A5055266545 @default.
• W1920604003 creator A5079311975 @default.
• W1920604003 creator A5090250872 @default.
• W1920604003 date "2015-07-21" @default.
• W1920604003 modified "2023-10-15" @default.
• W1920604003 title "Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes" @default.
• W1920604003 cites W1491202620 @default.
• W1920604003 cites W1752522506 @default.
• W1920604003 cites W1960825336 @default.
• W1920604003 cites W1963852432 @default.
• W1920604003 cites W1964656197 @default.
• W1920604003 cites W1971343583 @default.
• W1920604003 cites W1972990210 @default.
• W1920604003 cites W1975777549 @default.
• W1920604003 cites W1981007965 @default.
• W1920604003 cites W1982342532 @default.
• W1920604003 cites W1983981261 @default.
• W1920604003 cites W1987649195 @default.
• W1920604003 cites W2001902795 @default.
• W1920604003 cites W2013047715 @default.
• W1920604003 cites W2014641845 @default.
• W1920604003 cites W2045538543 @default.
• W1920604003 cites W2047780732 @default.
• W1920604003 cites W2053608922 @default.
• W1920604003 cites W2053826234 @default.
• W1920604003 cites W2056439450 @default.
• W1920604003 cites W2058649081 @default.
• W1920604003 cites W2059083569 @default.
• W1920604003 cites W2068753267 @default.
• W1920604003 cites W2080070851 @default.
• W1920604003 cites W2100358697 @default.
• W1920604003 cites W2110569728 @default.
• W1920604003 cites W2117938858 @default.
• W1920604003 cites W2121225884 @default.
• W1920604003 cites W2121264929 @default.
• W1920604003 cites W2130469036 @default.
• W1920604003 cites W2139494908 @default.
• W1920604003 cites W2143161390 @default.
• W1920604003 cites W2145777529 @default.
• W1920604003 cites W2159969745 @default.
• W1920604003 cites W2163388508 @default.
• W1920604003 cites W2163886829 @default.
• W1920604003 cites W2185844961 @default.
• W1920604003 cites W75397701 @default.
• W1920604003 doi "https://doi.org/10.1001/jama.2015.7996" @default.
• W1920604003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26197187" @default.
• W1920604003 hasPublicationYear "2015" @default.
• W1920604003 type Work @default.
• W1920604003 sameAs 1920604003 @default.
• W1920604003 citedByCount "254" @default.
• W1920604003 countsByYear W19206040032015 @default.
• W1920604003 countsByYear W19206040032016 @default.
• W1920604003 countsByYear W19206040032017 @default.
• W1920604003 countsByYear W19206040032018 @default.
• W1920604003 countsByYear W19206040032019 @default.
• W1920604003 countsByYear W19206040032020 @default.
• W1920604003 countsByYear W19206040032021 @default.
• W1920604003 countsByYear W19206040032022 @default.
• W1920604003 countsByYear W19206040032023 @default.
• W1920604003 crossrefType "journal-article" @default.
• W1920604003 hasAuthorship W1920604003A5001126649 @default.
• W1920604003 hasAuthorship W1920604003A5001652121 @default.
• W1920604003 hasAuthorship W1920604003A5023847764 @default.
• W1920604003 hasAuthorship W1920604003A5024575747 @default.
• W1920604003 hasAuthorship W1920604003A5029294320 @default.
• W1920604003 hasAuthorship W1920604003A5035439869 @default.
• W1920604003 hasAuthorship W1920604003A5041936168 @default.
• W1920604003 hasAuthorship W1920604003A5047557865 @default.
• W1920604003 hasAuthorship W1920604003A5051151649 @default.
• W1920604003 hasAuthorship W1920604003A5052785465 @default.
• W1920604003 hasAuthorship W1920604003A5055266545 @default.
• W1920604003 hasAuthorship W1920604003A5079311975 @default.
• W1920604003 hasAuthorship W1920604003A5090250872 @default.
• W1920604003 hasConcept C121608353 @default.
• W1920604003 hasConcept C126322002 @default.
• W1920604003 hasConcept C134018914 @default.
• W1920604003 hasConcept C143998085 @default.
• W1920604003 hasConcept C156957248 @default.
• W1920604003 hasConcept C201903717 @default.
• W1920604003 hasConcept C207103383 @default.
• W1920604003 hasConcept C2777180221 @default.
• W1920604003 hasConcept C2778384471 @default.
• W1920604003 hasConcept C2778527826 @default.
• W1920604003 hasConcept C2780192828 @default.
• W1920604003 hasConcept C2780352672 @default.
• W1920604003 hasConcept C44249647 @default.

• next