FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1920634525> ?p ?o ?g. }

• W1920634525 endingPage "2062" @default.
• W1920634525 startingPage "2055" @default.
• W1920634525 abstract "The aberrant expression of microRNAs (miRNAs/miRs) has been found in numerous cancer types. miR-32 is an oncomiR in prostate cancer (PCa), however, the mechanisms by which miR-32 functions as a regulator of radiotherapy response and resistance in PCa are largely unknown. In the present study, it was found that DAB2 interacting protein (DAB2IP), the miR-32-dependent tumor-suppressor gene, was downregulated and induced autophagy and inhibited radiotherapy-induced apoptosis in PCa cells. miR-32 expression was upregulated or overexpressed in PCa, and miR-32 inhibited DAB2IP expression through a direct binding site within the DAB2IP 3' untranslated region. miR-32 mimics enhanced tumor cell survival and decreased radiosensitivity in the PCa cells, which were reversed by miR-32 inhibitor. Flow cytometric analysis revealed that overexpressed miR-32, consistent with the DAB2IP-knockdown results, reduced ionizing radiation (IR)-induced cell apoptosis, which was restored by 4 nM brefeldin A treatment. More significantly, the overexpression of miR-32 and the knockdown of DAB2IP enhanced autophagy in the IR-treated PCa cells. miR-32 regulated the expression of autophagy-related proteins, such as DAB2IP, Beclin 1 and Light chain 3β I/II, as well as phosphorylation of S6 kinase and mammalian target of rapamycin. In conclusion, these data provide novel insights into the mechanisms governing the regulation of DAB2IP expression by miR-32 and their possible contribution to autophagy and radioresistance in PCa." @default.
• W1920634525 created "2016-06-24" @default.
• W1920634525 creator A5003554962 @default.
• W1920634525 creator A5026127656 @default.
• W1920634525 creator A5037879304 @default.
• W1920634525 creator A5069722548 @default.
• W1920634525 creator A5071158047 @default.
• W1920634525 creator A5083111913 @default.
• W1920634525 date "2015-07-30" @default.
• W1920634525 modified "2023-10-16" @default.
• W1920634525 title "microRNA-32 induces radioresistance by targeting DAB2IP and regulating autophagy in prostate cancer cells" @default.
• W1920634525 cites W144423133 @default.
• W1920634525 cites W1523693806 @default.
• W1920634525 cites W1597895778 @default.
• W1920634525 cites W1862251752 @default.
• W1920634525 cites W1955882699 @default.
• W1920634525 cites W1968870721 @default.
• W1920634525 cites W1971371013 @default.
• W1920634525 cites W1979562942 @default.
• W1920634525 cites W1981484848 @default.
• W1920634525 cites W1985144544 @default.
• W1920634525 cites W1989793529 @default.
• W1920634525 cites W1990376682 @default.
• W1920634525 cites W1993643473 @default.
• W1920634525 cites W2000097339 @default.
• W1920634525 cites W2002995168 @default.
• W1920634525 cites W2012371191 @default.
• W1920634525 cites W2018649033 @default.
• W1920634525 cites W2033893825 @default.
• W1920634525 cites W2034077125 @default.
• W1920634525 cites W2037320436 @default.
• W1920634525 cites W2038201817 @default.
• W1920634525 cites W2049528479 @default.
• W1920634525 cites W2065031087 @default.
• W1920634525 cites W2070412447 @default.
• W1920634525 cites W2071141495 @default.
• W1920634525 cites W2074500644 @default.
• W1920634525 cites W2080100430 @default.
• W1920634525 cites W2083919459 @default.
• W1920634525 cites W2085025875 @default.
• W1920634525 cites W2088685363 @default.
• W1920634525 cites W2093199757 @default.
• W1920634525 cites W2093557716 @default.
• W1920634525 cites W2099182542 @default.
• W1920634525 cites W2103665357 @default.
• W1920634525 cites W2103800516 @default.
• W1920634525 cites W2117535432 @default.
• W1920634525 cites W2127684282 @default.
• W1920634525 cites W2128365260 @default.
• W1920634525 cites W2134414272 @default.
• W1920634525 cites W2144105095 @default.
• W1920634525 cites W2147345880 @default.
• W1920634525 cites W2153607816 @default.
• W1920634525 cites W2160737079 @default.
• W1920634525 cites W2283382919 @default.
• W1920634525 cites W2597632520 @default.
• W1920634525 cites W70214305 @default.
• W1920634525 doi "https://doi.org/10.3892/ol.2015.3551" @default.
• W1920634525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4579868" @default.
• W1920634525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26622795" @default.
• W1920634525 hasPublicationYear "2015" @default.
• W1920634525 type Work @default.
• W1920634525 sameAs 1920634525 @default.
• W1920634525 citedByCount "46" @default.
• W1920634525 countsByYear W19206345252016 @default.
• W1920634525 countsByYear W19206345252017 @default.
• W1920634525 countsByYear W19206345252018 @default.
• W1920634525 countsByYear W19206345252019 @default.
• W1920634525 countsByYear W19206345252020 @default.
• W1920634525 countsByYear W19206345252021 @default.
• W1920634525 countsByYear W19206345252022 @default.
• W1920634525 countsByYear W19206345252023 @default.
• W1920634525 crossrefType "journal-article" @default.
• W1920634525 hasAuthorship W1920634525A5003554962 @default.
• W1920634525 hasAuthorship W1920634525A5026127656 @default.
• W1920634525 hasAuthorship W1920634525A5037879304 @default.
• W1920634525 hasAuthorship W1920634525A5069722548 @default.
• W1920634525 hasAuthorship W1920634525A5071158047 @default.
• W1920634525 hasAuthorship W1920634525A5083111913 @default.
• W1920634525 hasBestOaLocation W19206345251 @default.
• W1920634525 hasConcept C104317684 @default.
• W1920634525 hasConcept C127561419 @default.
• W1920634525 hasConcept C145059251 @default.
• W1920634525 hasConcept C173396325 @default.
• W1920634525 hasConcept C185592680 @default.
• W1920634525 hasConcept C190283241 @default.
• W1920634525 hasConcept C203522944 @default.
• W1920634525 hasConcept C2781018059 @default.
• W1920634525 hasConcept C29537977 @default.
• W1920634525 hasConcept C502942594 @default.
• W1920634525 hasConcept C54355233 @default.
• W1920634525 hasConcept C55493867 @default.
• W1920634525 hasConcept C58962609 @default.
• W1920634525 hasConcept C81885089 @default.
• W1920634525 hasConcept C86803240 @default.
• W1920634525 hasConcept C95444343 @default.
• W1920634525 hasConceptScore W1920634525C104317684 @default.
• W1920634525 hasConceptScore W1920634525C127561419 @default.

• next