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- W1920638567 abstract "Significance Numerous noncoding RNA molecules serve important functional and regulatory roles. How new RNA structures with novel functions emerge through the forces of evolution remains poorly understood. Here, we show how distinct units of structure (modules) within an individual RNA molecule can facilitate this evolution. We show that stress-exposed mutational effects can produce altered RNA structures, providing the raw material for the evolution of new functions. The two modules of the studied RNA molecule serve different roles in this process. This previously unidentified intramolecular mechanism for the hiding and release of mutational effects provides insight into how such a process might have contributed to the evolution of enzyme functions since life’s origins." @default.
- W1920638567 created "2016-06-24" @default.
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- W1920638567 date "2015-09-23" @default.
- W1920638567 modified "2023-10-14" @default.
- W1920638567 title "Intramolecular phenotypic capacitance in a modular RNA molecule" @default.
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- W1920638567 doi "https://doi.org/10.1073/pnas.1420902112" @default.
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