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- W192069810 abstract "Non-small cell lung cancer represents a group of heterogeneous diseases. The last decade witnessed significant progress in improving our understanding of the biology of non-small cell lung cancer, which led to the identification of several genetic targets. Those genetic targets were utilized to explain clinical phenomena, such as the occurrence of non-small cell lung cancer in never-smokers, to predict response to conventional chemotherapy and biological agents, and to explain and predict resistance to therapy. The progress in the treatment of non-small cell lung cancer in the last few years was based on a new generation of population-enriched clinical trials that utilized genetic targets such as somatic EGFR mutations and ALK-EML4 mutations. In this review we will discuss the available information about the key genetic markers of non-small cell lung cancer and the pivotal clinical trials that validate the use of those genetic markers in non-small cell lung cancer patients." @default.
- W192069810 created "2016-06-24" @default.
- W192069810 creator A5071092200 @default.
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- W192069810 date "2012-11-21" @default.
- W192069810 modified "2023-10-16" @default.
- W192069810 title "Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer" @default.
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- W192069810 doi "https://doi.org/10.1007/978-1-4614-6176-0_6" @default.
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