FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1920823193> ?p ?o ?g. }

• W1920823193 endingPage "7849" @default.
• W1920823193 startingPage "7844" @default.
• W1920823193 abstract "Using an animal model of drug relapse, we found that intermittent footshock stress reinstates alcohol seeking, an effect attenuated by the 5-HT reuptake blocker fluoxetine and by corticotropin-releasing factor (CRF) receptor antagonists. Here we studied the role of the 5-HT cell body region of the median raphe nucleus (MRN) and CRF receptors in this site in reinstatement of alcohol seeking. Rats were given alcohol in a two-bottle choice procedure (water vs alcohol) for 25 d and were then trained for 1 hr/d to press a lever for alcohol (12% w/v) for 23–30 d. Subsequently, lever pressing for alcohol was extinguished by terminating drug delivery for 5–9 d. Tests for reinstatement of alcohol seeking were then performed under extinction conditions. Intra-MRN infusions of 8-OH-DPAT [8-hydroxy-2-(di-<i>n</i>-propylamino)tetralin] (a 5-HT_1A agonist that decreases 5-HT cell firing and release) reinstated alcohol seeking. Reinstatement of alcohol seeking also was observed after intra-MRN infusions of low doses of CRF (3–10 ng), which mimicked the effect of ventricular infusions of higher doses of the peptide (300–1000 ng). Finally, intra-MRN infusions of the CRF receptor antagonist <i>d</i>-Phe CRF (50 ng) blocked the effect of intermittent footshock (10 min) on reinstatement. These data suggest that an interaction between CRF and 5-HT neurons within the MRN is involved in footshock stress-induced reinstatement of alcohol seeking." @default.
• W1920823193 created "2016-06-24" @default.
• W1920823193 creator A5020779526 @default.
• W1920823193 creator A5033903495 @default.
• W1920823193 creator A5057774177 @default.
• W1920823193 creator A5066436685 @default.
• W1920823193 creator A5088492767 @default.
• W1920823193 date "2002-09-15" @default.
• W1920823193 modified "2023-10-17" @default.
• W1920823193 title "The Role of Corticotropin-Releasing Factor in the Median Raphe Nucleus in Relapse to Alcohol" @default.
• W1920823193 cites W1482038383 @default.
• W1920823193 cites W1518117902 @default.
• W1920823193 cites W1671645500 @default.
• W1920823193 cites W1856909901 @default.
• W1920823193 cites W1924585284 @default.
• W1920823193 cites W1949947575 @default.
• W1920823193 cites W1951492130 @default.
• W1920823193 cites W1964838523 @default.
• W1920823193 cites W1970920529 @default.
• W1920823193 cites W1973872563 @default.
• W1920823193 cites W1984112731 @default.
• W1920823193 cites W1984345409 @default.
• W1920823193 cites W1984346427 @default.
• W1920823193 cites W1994054590 @default.
• W1920823193 cites W1999429814 @default.
• W1920823193 cites W2004254122 @default.
• W1920823193 cites W2011956138 @default.
• W1920823193 cites W2012416101 @default.
• W1920823193 cites W2019912621 @default.
• W1920823193 cites W2023397088 @default.
• W1920823193 cites W2035266273 @default.
• W1920823193 cites W2037868801 @default.
• W1920823193 cites W2041736210 @default.
• W1920823193 cites W2044823814 @default.
• W1920823193 cites W2061286825 @default.
• W1920823193 cites W2063884040 @default.
• W1920823193 cites W2066335559 @default.
• W1920823193 cites W2069472087 @default.
• W1920823193 cites W2074140874 @default.
• W1920823193 cites W2091456614 @default.
• W1920823193 cites W2095119333 @default.
• W1920823193 cites W2102035457 @default.
• W1920823193 cites W2109594449 @default.
• W1920823193 cites W2127504265 @default.
• W1920823193 cites W2139368987 @default.
• W1920823193 doi "https://doi.org/10.1523/jneurosci.22-18-07844.2002" @default.
• W1920823193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6758102" @default.
• W1920823193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12223536" @default.
• W1920823193 hasPublicationYear "2002" @default.
• W1920823193 type Work @default.
• W1920823193 sameAs 1920823193 @default.
• W1920823193 citedByCount "126" @default.
• W1920823193 countsByYear W19208231932012 @default.
• W1920823193 countsByYear W19208231932013 @default.
• W1920823193 countsByYear W19208231932014 @default.
• W1920823193 countsByYear W19208231932015 @default.
• W1920823193 countsByYear W19208231932016 @default.
• W1920823193 countsByYear W19208231932017 @default.
• W1920823193 countsByYear W19208231932018 @default.
• W1920823193 countsByYear W19208231932019 @default.
• W1920823193 countsByYear W19208231932020 @default.
• W1920823193 countsByYear W19208231932021 @default.
• W1920823193 countsByYear W19208231932022 @default.
• W1920823193 countsByYear W19208231932023 @default.
• W1920823193 crossrefType "journal-article" @default.
• W1920823193 hasAuthorship W1920823193A5020779526 @default.
• W1920823193 hasAuthorship W1920823193A5033903495 @default.
• W1920823193 hasAuthorship W1920823193A5057774177 @default.
• W1920823193 hasAuthorship W1920823193A5066436685 @default.
• W1920823193 hasAuthorship W1920823193A5088492767 @default.
• W1920823193 hasBestOaLocation W19208231931 @default.
• W1920823193 hasConcept C101991246 @default.
• W1920823193 hasConcept C126322002 @default.
• W1920823193 hasConcept C134018914 @default.
• W1920823193 hasConcept C15744967 @default.
• W1920823193 hasConcept C170493617 @default.
• W1920823193 hasConcept C185592680 @default.
• W1920823193 hasConcept C199289684 @default.
• W1920823193 hasConcept C2775864247 @default.
• W1920823193 hasConcept C2776570665 @default.
• W1920823193 hasConcept C2776885963 @default.
• W1920823193 hasConcept C2777865548 @default.
• W1920823193 hasConcept C2778555786 @default.
• W1920823193 hasConcept C2778938600 @default.
• W1920823193 hasConcept C2781066024 @default.
• W1920823193 hasConcept C32610206 @default.
• W1920823193 hasConcept C37000724 @default.
• W1920823193 hasConcept C55493867 @default.
• W1920823193 hasConcept C71924100 @default.
• W1920823193 hasConcept C98274493 @default.
• W1920823193 hasConceptScore W1920823193C101991246 @default.
• W1920823193 hasConceptScore W1920823193C126322002 @default.
• W1920823193 hasConceptScore W1920823193C134018914 @default.
• W1920823193 hasConceptScore W1920823193C15744967 @default.
• W1920823193 hasConceptScore W1920823193C170493617 @default.
• W1920823193 hasConceptScore W1920823193C185592680 @default.
• W1920823193 hasConceptScore W1920823193C199289684 @default.
• W1920823193 hasConceptScore W1920823193C2775864247 @default.

• next