FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1920829488> ?p ?o ?g. }

• W1920829488 endingPage "571" @default.
• W1920829488 startingPage "561" @default.
• W1920829488 abstract "DT-diaphorase catalysed the reduction of 1,4-naphthoquinones with hydroxy, methyl, methoxy and glutathionyl substituents at the expense of reducing equivalents from NADPH. The initial rates of quinone reduction did not correlate with either the half-wave reduction potential (E1/2) value (determined by h.p.l.c. with electrochemical detection against an Ag/AgCl reference electrode) or the partition coefficient of the quinones. After their reduction by DT-diaphorase the 1,4-naphthoquinone derivatives autoxidized at distinct rates, the extent of which was influenced by the nature of the substituents. Thus for the 1,4-naphthoquinone series the following order of rate of autoxidation was found: 5-hydroxy-1,4-naphthoquinone greater than 3-glutathionyl-1,4-naphthoquinone greater than 5-hydroxy-3-glutathionyl-1,4-naphthoquinone greater than 1,4-naphthoquinone greater than 2-hydroxy-1,4-naphthoquinone. For the 2-methyl-1,4-naphthoquinone (menadione) series the following order was observed: 5-hydroxy-2-methyl-1,4-naphthoquinone greater than 3-glutathionyl-5-hydroxy-2-methyl-1,4-naphthoquinone greater than 3-glutathionyl-2-methyl-1,4-naphthoquinone greater than 2-methyl-1,4-naphthoquinone greater than 3-hydroxy-2-methyl-1,4-naphthoquinone. The autoxidized naphthohydroquinone derivatives were re-reduced by DT-diaphorase, thus closing a cycle of enzymic reduction in equilibrium autoxidation. This was expressed as an excess of NADPH oxidized over the initial concentration of quinone present as well as H2O2 formation. These findings demonstrate that glutathionyl conjugates of 1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone and those of their respective 5-hydroxy derivatives are able to act as substrates for DT-diaphorase and that they also autoxidize at rates higher than those for the unsubstituted parent compounds. These results are discussed in terms of the cellular role of DT-diaphorase in the reduction of hydroxy- or glutathionyl-substituted naphthoquinones as well as the further conjugation of these hydroquinones with glucuronide or sulphate within the cellular milieu, thereby facilitating their disposal from the cells." @default.
• W1920829488 created "2016-06-24" @default.
• W1920829488 creator A5001715806 @default.
• W1920829488 creator A5011283472 @default.
• W1920829488 creator A5013206192 @default.
• W1920829488 creator A5056159724 @default.
• W1920829488 date "1989-01-15" @default.
• W1920829488 modified "2023-09-25" @default.
• W1920829488 title "DT-diaphorase-catalysed reduction of 1,4-naphthoquinone derivatives and glutathionyl-quinone conjugates. Effect of substituents on autoxidation rates" @default.
• W1920829488 cites W1503552721 @default.
• W1920829488 cites W1513059355 @default.
• W1920829488 cites W1530248156 @default.
• W1920829488 cites W1536773986 @default.
• W1920829488 cites W1548555083 @default.
• W1920829488 cites W1549655192 @default.
• W1920829488 cites W1559871277 @default.
• W1920829488 cites W1592087595 @default.
• W1920829488 cites W1595656597 @default.
• W1920829488 cites W1972901292 @default.
• W1920829488 cites W1975823218 @default.
• W1920829488 cites W1992275578 @default.
• W1920829488 cites W1992346119 @default.
• W1920829488 cites W2000342420 @default.
• W1920829488 cites W2004329247 @default.
• W1920829488 cites W2005582911 @default.
• W1920829488 cites W2026858124 @default.
• W1920829488 cites W2030524237 @default.
• W1920829488 cites W2042365947 @default.
• W1920829488 cites W2042882924 @default.
• W1920829488 cites W2046118936 @default.
• W1920829488 cites W2060013516 @default.
• W1920829488 cites W2063095563 @default.
• W1920829488 cites W2068596614 @default.
• W1920829488 cites W2069486511 @default.
• W1920829488 cites W2077604639 @default.
• W1920829488 cites W2081080433 @default.
• W1920829488 cites W2087280499 @default.
• W1920829488 cites W2136677249 @default.
• W1920829488 cites W2152113767 @default.
• W1920829488 cites W2468064680 @default.
• W1920829488 doi "https://doi.org/10.1042/bj2570561" @default.
• W1920829488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1135615" @default.
• W1920829488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2494985" @default.
• W1920829488 hasPublicationYear "1989" @default.
• W1920829488 type Work @default.
• W1920829488 sameAs 1920829488 @default.
• W1920829488 citedByCount "163" @default.
• W1920829488 countsByYear W19208294882012 @default.
• W1920829488 countsByYear W19208294882013 @default.
• W1920829488 countsByYear W19208294882014 @default.
• W1920829488 countsByYear W19208294882015 @default.
• W1920829488 countsByYear W19208294882016 @default.
• W1920829488 countsByYear W19208294882017 @default.
• W1920829488 countsByYear W19208294882018 @default.
• W1920829488 countsByYear W19208294882019 @default.
• W1920829488 countsByYear W19208294882020 @default.
• W1920829488 countsByYear W19208294882021 @default.
• W1920829488 countsByYear W19208294882023 @default.
• W1920829488 crossrefType "journal-article" @default.
• W1920829488 hasAuthorship W1920829488A5001715806 @default.
• W1920829488 hasAuthorship W1920829488A5011283472 @default.
• W1920829488 hasAuthorship W1920829488A5013206192 @default.
• W1920829488 hasAuthorship W1920829488A5056159724 @default.
• W1920829488 hasBestOaLocation W19208294882 @default.
• W1920829488 hasConcept C155647269 @default.
• W1920829488 hasConcept C178790620 @default.
• W1920829488 hasConcept C181199279 @default.
• W1920829488 hasConcept C185592680 @default.
• W1920829488 hasConcept C2776183150 @default.
• W1920829488 hasConcept C2778655850 @default.
• W1920829488 hasConcept C2780643102 @default.
• W1920829488 hasConcept C2781095387 @default.
• W1920829488 hasConcept C37329643 @default.
• W1920829488 hasConcept C71240020 @default.
• W1920829488 hasConceptScore W1920829488C155647269 @default.
• W1920829488 hasConceptScore W1920829488C178790620 @default.
• W1920829488 hasConceptScore W1920829488C181199279 @default.
• W1920829488 hasConceptScore W1920829488C185592680 @default.
• W1920829488 hasConceptScore W1920829488C2776183150 @default.
• W1920829488 hasConceptScore W1920829488C2778655850 @default.
• W1920829488 hasConceptScore W1920829488C2780643102 @default.
• W1920829488 hasConceptScore W1920829488C2781095387 @default.
• W1920829488 hasConceptScore W1920829488C37329643 @default.
• W1920829488 hasConceptScore W1920829488C71240020 @default.
• W1920829488 hasIssue "2" @default.
• W1920829488 hasLocation W19208294881 @default.
• W1920829488 hasLocation W19208294882 @default.
• W1920829488 hasLocation W19208294883 @default.
• W1920829488 hasLocation W19208294884 @default.
• W1920829488 hasOpenAccess W1920829488 @default.
• W1920829488 hasPrimaryLocation W19208294881 @default.
• W1920829488 hasRelatedWork W1586031145 @default.
• W1920829488 hasRelatedWork W1920829488 @default.
• W1920829488 hasRelatedWork W1994300233 @default.
• W1920829488 hasRelatedWork W2001229739 @default.
• W1920829488 hasRelatedWork W2006352154 @default.
• W1920829488 hasRelatedWork W2055986815 @default.
• W1920829488 hasRelatedWork W2321309771 @default.

• next