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• W1921076722 endingPage "1711" @default.
• W1921076722 startingPage "1693" @default.
• W1921076722 abstract "Cells of the immune system provide particularly fruitful subjects for the study of lineage commitment. Both T and B lymphocytes undergo complicated patterns of differentiation from uncommitted, nonfunctional precursor cells to highly sophisticated effector cells. The development of the helper T lymphocyte is one of the most elegant examples of this. A little over a decade ago, Mosmann and Coffman (1989) discovered that naive mouse CD4 T helper lymphocytes, upon receiving an antigenic stimulus, differentiate into two distinct subsets defined both by their function and by unique cytokine profiles. These subsets, T helper 1 (Th1) and T helper 2 (Th2) (Mosmann et al. 1986; Mosmann and Coffman 1989; Paul and Seder 1994; O’Garra 1998; Rengarajan and Glimcher 2000), are responsible for cell-mediated/inflammatory immunity and humoral responses, respectively (Fig. 1). This division of labor fits nicely with previous demonstrations that an organism tends to mount either a cell-mediated or humoral response, but not both, in response to pathogens. The function of T helper cells can largely be explained by the cytokines they secrete. Cytokines (or lymphokines) are small hormone-like polypeptides that have pleiotrophic biological activities in several cell types. Resting T cells do not transcribe cytokine genes, but they are rapidly induced upon coactivation through the T-cell receptor (TCR) and costimulatory receptors (Lenschow et al. 1996). Much progress has been made in identifying the signaling pathways and transcription factors that control Th1 and Th2 differentiation as shown schematically (Fig. 2a). This review will summarize what is currently known about the signals that regulate lineage commitment in T helper cells with a special focus on three subset-specific transcription factors, T-bet, GATA-3, and c-Maf, responsible for lineage commitment (Fig. 2b)." @default.
• W1921076722 created "2016-06-24" @default.
• W1921076722 creator A5040420168 @default.
• W1921076722 creator A5074049778 @default.
• W1921076722 date "2000-07-15" @default.
• W1921076722 modified "2023-10-17" @default.
• W1921076722 title "Lineage commitment in the immune system: the T helper lymphocyte grows up" @default.
• W1921076722 cites W1497205974 @default.
• W1921076722 cites W1497402347 @default.
• W1921076722 cites W1499263634 @default.
• W1921076722 cites W1500581281 @default.
• W1921076722 cites W1514549604 @default.
• W1921076722 cites W1515586509 @default.
• W1921076722 cites W1521285578 @default.
• W1921076722 cites W1522816379 @default.
• W1921076722 cites W1525833221 @default.
• W1921076722 cites W1528831675 @default.
• W1921076722 cites W1534759724 @default.
• W1921076722 cites W1542262758 @default.
• W1921076722 cites W1543271400 @default.
• W1921076722 cites W1562527353 @default.
• W1921076722 cites W1568317937 @default.
• W1921076722 cites W1570604385 @default.
• W1921076722 cites W1577781573 @default.
• W1921076722 cites W1588331058 @default.
• W1921076722 cites W1604795805 @default.
• W1921076722 cites W1605898561 @default.
• W1921076722 cites W1607111607 @default.
• W1921076722 cites W1607206898 @default.
• W1921076722 cites W1609713897 @default.
• W1921076722 cites W1613769575 @default.
• W1921076722 cites W1661441964 @default.
• W1921076722 cites W1668449847 @default.
• W1921076722 cites W1727750278 @default.
• W1921076722 cites W1811517392 @default.
• W1921076722 cites W1817534450 @default.
• W1921076722 cites W1827812119 @default.
• W1921076722 cites W1836730957 @default.
• W1921076722 cites W1836845228 @default.
• W1921076722 cites W1881583814 @default.
• W1921076722 cites W1894525365 @default.
• W1921076722 cites W1908351116 @default.
• W1921076722 cites W1942668068 @default.
• W1921076722 cites W1962193832 @default.
• W1921076722 cites W1964612504 @default.
• W1921076722 cites W1964973658 @default.
• W1921076722 cites W1965490529 @default.
• W1921076722 cites W1967261754 @default.
• W1921076722 cites W1969213218 @default.
• W1921076722 cites W1969507577 @default.
• W1921076722 cites W1969912242 @default.
• W1921076722 cites W1973249104 @default.
• W1921076722 cites W1975588465 @default.
• W1921076722 cites W1975602003 @default.
• W1921076722 cites W1976140288 @default.
• W1921076722 cites W1977655229 @default.
• W1921076722 cites W1977795184 @default.
• W1921076722 cites W1979514172 @default.
• W1921076722 cites W1980000158 @default.
• W1921076722 cites W1981027928 @default.
• W1921076722 cites W1983067916 @default.
• W1921076722 cites W1983367618 @default.
• W1921076722 cites W1984338631 @default.
• W1921076722 cites W1985582499 @default.
• W1921076722 cites W1985677612 @default.
• W1921076722 cites W1987485969 @default.
• W1921076722 cites W1987684167 @default.
• W1921076722 cites W1988707760 @default.
• W1921076722 cites W1988820544 @default.
• W1921076722 cites W1989680178 @default.
• W1921076722 cites W1990500865 @default.
• W1921076722 cites W1991082879 @default.
• W1921076722 cites W1991311051 @default.
• W1921076722 cites W1994048684 @default.
• W1921076722 cites W1994894837 @default.
• W1921076722 cites W1995530329 @default.
• W1921076722 cites W1997531619 @default.
• W1921076722 cites W1998529985 @default.
• W1921076722 cites W1999015543 @default.
• W1921076722 cites W2000581651 @default.
• W1921076722 cites W2001713238 @default.
• W1921076722 cites W2002186586 @default.
• W1921076722 cites W2002485919 @default.
• W1921076722 cites W2002861511 @default.
• W1921076722 cites W2003310898 @default.
• W1921076722 cites W2004143904 @default.
• W1921076722 cites W2006610332 @default.
• W1921076722 cites W2006877529 @default.
• W1921076722 cites W2008690193 @default.
• W1921076722 cites W2010428440 @default.
• W1921076722 cites W2011328327 @default.
• W1921076722 cites W2011608246 @default.
• W1921076722 cites W2011641869 @default.
• W1921076722 cites W2011952922 @default.
• W1921076722 cites W2012628280 @default.
• W1921076722 cites W2013056080 @default.
• W1921076722 cites W2013279950 @default.
• W1921076722 cites W2016642606 @default.

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