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- W1921085928 abstract "New semisynthetic chitosan derivatives were prepared by grafting chitosan with lactate and phthalate substituents. The resulting polymers were successfully employed in the formation of polymeric beads by facile ionotropic crosslinking with zinc or aluminum ions. Ionic crosslinking was confirmed by infrared spectroscopy and differential scanning calorimetry. The produced beads were loaded with phenobarbitone (PhB) as a model drug and evaluated as potential controlled release matrices. Interestingly, the loaded beads illustrated pH-dependent release profiles with enteric properties and prolonged release under simulated intestinal fluids. The newly modified polymers offer attractive alternatives for the conventional chitosan polymers especially for oral delivery and help to overcome some of their drawbacks in controlling drug release." @default.
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- W1921085928 date "2015-12-01" @default.
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- W1921085928 title "Synthesis and characterization of chitosan-lactate–phthalate and evaluation of the corresponding zinc- and aluminum-crosslinked beads as potential controlled release matrices" @default.
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- W1921085928 doi "https://doi.org/10.1016/j.eurpolymj.2015.11.004" @default.
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