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• W1921090969 abstract "Abstract In the present study, we demonstrated that D-aspartate acts as an in vitro and in vivo neuromodulatory molecule upon hippocampal NMDAR transmission. Accordingly, we showed that this D-amino acid, widely expressed during embryonic phase, was able to strongly influence hippocampus-related functions at adulthood. Thus, while up-regulated levels of D-aspartate increased LTP and spatial memory in four-month old adult mice, the prolonged deregulation of this molecule in thirteen-month old animals induced a substantial acceleration of age-dependent decay of synaptic plasticity and cognitive functions. Moreover, we highlighted a role for D-aspartate in enhancing NMDAR-dependent synaptic plasticity through an inducible &quot;turn-on/turn-off-like mechanism&quot;. Strikingly, we also showed that D-aspartate, when administered to aged mice, strongly rescued their physiological synaptic decay and attenuated their cognitive deterioration. In conclusion, our data suggest a tantalizing hypothesis for which this in-embryo-occurring D-amino acid, might disclose plasticity windows in the aging brain." @default.
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• W1921090969 date "2008-05-15" @default.
• W1921090969 modified "2023-10-18" @default.
• W1921090969 title "D-aspartate exerts an opposing role upon age-dependent NMDAR-related synaptic plasticity and memory decay" @default.
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• W1921090969 doi "https://doi.org/10.1038/npre.2008.1891.1" @default.
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