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• W1921191574 abstract "Abstract Background and Aim: Genetic variations and the expression profile of matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) are involved in the invasion and metastasis of colorectal cancer. Methods: The gene profiles of TIMP2 and MMP were assayed from 333 colorectal cancer using polymerase chain reaction–restriction fragment length polymorphism. Results: TIMP2‐418*G/ * G, TIMP2 303 * G/ * G and MMP9‐1562*C/ * C were more frequent in patients than in controls ( P = 0.020, P < 0.0001 and P < 0.044, respectively). Frequency of TIMP2‐418 * G/ * G was higher in patients with metastasis than in those without metastasis, and that of TIMP2 303 * G/ * G was higher in patients with rectal cancer than in those with colon cancer ( P = 0.008 and P = 0.022, respectively). TIMP2‐303 * A/ * A and MMP2‐1575 * G/ * G were less frequent in patients than in controls ( P = 0.001 and P = 0.005, respectively). The TIMP2‐418 * G303 * G haplotype was more frequent ( P < 0.0001) and MMP2‐1575 * G‐735 * C haplotype was less frequent in patients than in controls ( P = 0.005). Conclusion: Specific single‐nucleotide polymorphism in TIMP2 and MMP appeared to be associated with tumorigenesis and biological behavior in colorectal cancer, which is expected be further verified in a larger cohort in the future." @default.
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• W1921191574 date "2011-01-25" @default.
• W1921191574 modified "2023-10-16" @default.
• W1921191574 title "Clinical characteristics of TIMP2, MMP2, and MMP9 gene polymorphisms in colorectal cancer" @default.
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• W1921191574 doi "https://doi.org/10.1111/j.1440-1746.2010.06504.x" @default.
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