FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1921595536> ?p ?o ?g. }

• W1921595536 endingPage "980" @default.
• W1921595536 startingPage "974" @default.
• W1921595536 abstract "Preclinical data suggests that memantine, a noncompetitive glutamate N-methyl- D-aspartate-receptor blocker used for the treatment of moderate to severe Alzheimer's disease, could reduce depressive and amotivated behavior occurring in the context of psychosocial stress. Therefore, we examined whether memantine could reduce depressive symptoms and amotivation manifesting in older adults after a disabling medical event, thereby improving their functional recovery.We recruited subjects aged 60 years and older who had recently suffered a disabling medical event and were admitted to a skilled nursing facility for rehabilitation. Participants with significant depressive symptoms, defined as a Hamilton Rating Scale for Depression score of 10 or greater, and/or significant apathy symptoms, defined as an Apathy Evaluation Scale score of 40 or greater, were randomized to memantine (10 mg/d for 1 week, then 10 mg twice daily) or placebo, for 12 weeks. We also recruited participants without depressive or apathy symptoms for naturalistic follow-up as a non-depressed comparison group. Depressive and apathy symptoms were main outcomes; functional recovery, and self-report rating of helplessness, and onset of new depressive disorders were secondary outcomes.Thirty-five older adults with significant depressive and/or apathy symptoms were randomized, of whom 27 (77.1%) completed the 12 week randomized controlled trial. Both groups showed reduction in depressive symptoms (but no significant reduction in apathy symptoms) and improved function. However, there were no group differences between the memantine-randomized and placebo randomized participants on any outcome.Memantine was not associated with superior affective or functional outcome compared with placebo in medically rehabilitating older adults with depressive and apathy symptoms." @default.
• W1921595536 created "2016-06-24" @default.
• W1921595536 creator A5036489827 @default.
• W1921595536 creator A5053095971 @default.
• W1921595536 creator A5076904256 @default.
• W1921595536 creator A5085456146 @default.
• W1921595536 creator A5085696063 @default.
• W1921595536 creator A5088728325 @default.
• W1921595536 date "2011-12-16" @default.
• W1921595536 modified "2023-09-25" @default.
• W1921595536 title "Memantine for late-life depression and apathy after a disabling medical event: a 12-week, double-blind placebo-controlled pilot study" @default.
• W1921595536 cites W1533240928 @default.
• W1921595536 cites W1551071843 @default.
• W1921595536 cites W1577880037 @default.
• W1921595536 cites W1847168837 @default.
• W1921595536 cites W1966438037 @default.
• W1921595536 cites W1982921548 @default.
• W1921595536 cites W1984511502 @default.
• W1921595536 cites W1989844512 @default.
• W1921595536 cites W2008291494 @default.
• W1921595536 cites W2008879636 @default.
• W1921595536 cites W2017273813 @default.
• W1921595536 cites W2023081218 @default.
• W1921595536 cites W2023529093 @default.
• W1921595536 cites W2024793069 @default.
• W1921595536 cites W2035920294 @default.
• W1921595536 cites W2035986146 @default.
• W1921595536 cites W2044063521 @default.
• W1921595536 cites W2047397795 @default.
• W1921595536 cites W2060398917 @default.
• W1921595536 cites W2095537776 @default.
• W1921595536 cites W2103140216 @default.
• W1921595536 cites W2107495548 @default.
• W1921595536 cites W2109334244 @default.
• W1921595536 cites W2114613490 @default.
• W1921595536 cites W2115826107 @default.
• W1921595536 cites W2118815581 @default.
• W1921595536 cites W2135212902 @default.
• W1921595536 cites W2146344805 @default.
• W1921595536 cites W2163709153 @default.
• W1921595536 cites W2170790660 @default.
• W1921595536 cites W2172167642 @default.
• W1921595536 cites W4237746773 @default.
• W1921595536 cites W4237791656 @default.
• W1921595536 cites W4242419989 @default.
• W1921595536 doi "https://doi.org/10.1002/gps.2813" @default.
• W1921595536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3601891" @default.
• W1921595536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22173933" @default.
• W1921595536 hasPublicationYear "2011" @default.
• W1921595536 type Work @default.
• W1921595536 sameAs 1921595536 @default.
• W1921595536 citedByCount "51" @default.
• W1921595536 countsByYear W19215955362012 @default.
• W1921595536 countsByYear W19215955362013 @default.
• W1921595536 countsByYear W19215955362014 @default.
• W1921595536 countsByYear W19215955362015 @default.
• W1921595536 countsByYear W19215955362016 @default.
• W1921595536 countsByYear W19215955362017 @default.
• W1921595536 countsByYear W19215955362018 @default.
• W1921595536 countsByYear W19215955362019 @default.
• W1921595536 countsByYear W19215955362020 @default.
• W1921595536 countsByYear W19215955362021 @default.
• W1921595536 countsByYear W19215955362022 @default.
• W1921595536 countsByYear W19215955362023 @default.
• W1921595536 crossrefType "journal-article" @default.
• W1921595536 hasAuthorship W1921595536A5036489827 @default.
• W1921595536 hasAuthorship W1921595536A5053095971 @default.
• W1921595536 hasAuthorship W1921595536A5076904256 @default.
• W1921595536 hasAuthorship W1921595536A5085456146 @default.
• W1921595536 hasAuthorship W1921595536A5085696063 @default.
• W1921595536 hasAuthorship W1921595536A5088728325 @default.
• W1921595536 hasBestOaLocation W19215955362 @default.
• W1921595536 hasConcept C118552586 @default.
• W1921595536 hasConcept C126322002 @default.
• W1921595536 hasConcept C139719470 @default.
• W1921595536 hasConcept C142724271 @default.
• W1921595536 hasConcept C151730666 @default.
• W1921595536 hasConcept C15744967 @default.
• W1921595536 hasConcept C162324750 @default.
• W1921595536 hasConcept C168563851 @default.
• W1921595536 hasConcept C169900460 @default.
• W1921595536 hasConcept C1862650 @default.
• W1921595536 hasConcept C204787440 @default.
• W1921595536 hasConcept C27081682 @default.
• W1921595536 hasConcept C2776509080 @default.
• W1921595536 hasConcept C2776867660 @default.
• W1921595536 hasConcept C2779134260 @default.
• W1921595536 hasConcept C2779343474 @default.
• W1921595536 hasConcept C2779483572 @default.
• W1921595536 hasConcept C2779484449 @default.
• W1921595536 hasConcept C71924100 @default.
• W1921595536 hasConcept C86803240 @default.
• W1921595536 hasConceptScore W1921595536C118552586 @default.
• W1921595536 hasConceptScore W1921595536C126322002 @default.
• W1921595536 hasConceptScore W1921595536C139719470 @default.
• W1921595536 hasConceptScore W1921595536C142724271 @default.
• W1921595536 hasConceptScore W1921595536C151730666 @default.
• W1921595536 hasConceptScore W1921595536C15744967 @default.

• next