FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1921616792> ?p ?o ?g. }

• W1921616792 endingPage "1895" @default.
• W1921616792 startingPage "1895" @default.
• W1921616792 abstract "To determine the role of c-Jun N-terminal kinase (JNK) activity in ethanol-induced apoptosis and the modulation of this signaling cascade by S-Adenosyl-methionine (AdoMet).Primary hepatocyte cultures were pretreated with 100 micromol/L SP600125, a selective JNK inhibitor, 1 mL/L DMSO or 4 mmol/L AdoMet and then exposed to 100 mmo/L ethanol. Hepatocyte apoptosis was determined by the TUNEL and DNA ladder assays. JNK activity and its inhibition by SP600125 and AdoMet were determined by Western blot analysis of c-jun phosphorylation and Bid fragmentation. SP600125 and AdoMet effects on the apoptotic signaling pathway were determined by Western blot analysis of cytochrome c release and pro-caspase 3 fragmentation. The AdoMet effect on glutathione levels was measured by Ellman's method and reactive oxygen species (ROS) generation by cell cytometry.The exposure of hepatocytes to ethanol induced JNK activation, c-jun phosphorylation, Bid fragmentation, cytochrome c release and pro-caspase 3 cleavage; these effects were diminished by SP600125, and caused a significant decrease in ethanol-induced apoptosis (P< 0.05). AdoMet exerted an antioxidant effect maintaining glutathione levels and decreasing ROS generation, without a significant effect on JNK activity, and prevented cytochrome c release and pro-caspase 3 cleavage.The JNK signaling cascade is a key component of the proapoptotic signaling pathway induced by ethanol. JNK activation may be independent from ROS generation, since AdoMet which exerted antioxidant properties did not have a significant effect on JNK activity. JNK pathway modulator agents and AdoMet may be components of promising therapies for alcoholic liver disease (ALD) treatment." @default.
• W1921616792 created "2016-06-24" @default.
• W1921616792 creator A5042351421 @default.
• W1921616792 date "2006-01-01" @default.
• W1921616792 modified "2023-09-27" @default.
• W1921616792 title "S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism" @default.
• W1921616792 cites W1491137382 @default.
• W1921616792 cites W1541528064 @default.
• W1921616792 cites W1968261026 @default.
• W1921616792 cites W1968560682 @default.
• W1921616792 cites W1972815173 @default.
• W1921616792 cites W1990065094 @default.
• W1921616792 cites W1997121321 @default.
• W1921616792 cites W1997962280 @default.
• W1921616792 cites W2002240376 @default.
• W1921616792 cites W2002646580 @default.
• W1921616792 cites W2005048288 @default.
• W1921616792 cites W2006370393 @default.
• W1921616792 cites W2010139831 @default.
• W1921616792 cites W2018404966 @default.
• W1921616792 cites W2022189400 @default.
• W1921616792 cites W2031385133 @default.
• W1921616792 cites W2054873020 @default.
• W1921616792 cites W2056324134 @default.
• W1921616792 cites W2057685032 @default.
• W1921616792 cites W2059096914 @default.
• W1921616792 cites W2062853648 @default.
• W1921616792 cites W2065309817 @default.
• W1921616792 cites W2065463296 @default.
• W1921616792 cites W2066072238 @default.
• W1921616792 cites W2072482644 @default.
• W1921616792 cites W2074169536 @default.
• W1921616792 cites W2077557446 @default.
• W1921616792 cites W2078268792 @default.
• W1921616792 cites W2084015464 @default.
• W1921616792 cites W2092898235 @default.
• W1921616792 cites W2096931514 @default.
• W1921616792 cites W2097672870 @default.
• W1921616792 cites W2098676615 @default.
• W1921616792 cites W2105849697 @default.
• W1921616792 cites W2109017691 @default.
• W1921616792 cites W2114918609 @default.
• W1921616792 cites W2115368090 @default.
• W1921616792 cites W2119807130 @default.
• W1921616792 cites W2130232098 @default.
• W1921616792 cites W2136953396 @default.
• W1921616792 cites W2137122673 @default.
• W1921616792 cites W2138209882 @default.
• W1921616792 cites W2142783613 @default.
• W1921616792 cites W2149642592 @default.
• W1921616792 cites W2164176210 @default.
• W1921616792 cites W2170236911 @default.
• W1921616792 cites W2188733915 @default.
• W1921616792 cites W2338331104 @default.
• W1921616792 cites W2504810882 @default.
• W1921616792 cites W4237120149 @default.
• W1921616792 cites W4246414320 @default.
• W1921616792 cites W4320573465 @default.
• W1921616792 cites W4362196385 @default.
• W1921616792 cites W2057019723 @default.
• W1921616792 doi "https://doi.org/10.3748/wjg.v12.i12.1895" @default.
• W1921616792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4087515" @default.
• W1921616792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16609996" @default.
• W1921616792 hasPublicationYear "2006" @default.
• W1921616792 type Work @default.
• W1921616792 sameAs 1921616792 @default.
• W1921616792 citedByCount "12" @default.
• W1921616792 countsByYear W19216167922012 @default.
• W1921616792 countsByYear W19216167922015 @default.
• W1921616792 countsByYear W19216167922016 @default.
• W1921616792 countsByYear W19216167922020 @default.
• W1921616792 countsByYear W19216167922021 @default.
• W1921616792 crossrefType "journal-article" @default.
• W1921616792 hasAuthorship W1921616792A5042351421 @default.
• W1921616792 hasBestOaLocation W19216167921 @default.
• W1921616792 hasConcept C104317684 @default.
• W1921616792 hasConcept C11960822 @default.
• W1921616792 hasConcept C12519072 @default.
• W1921616792 hasConcept C153911025 @default.
• W1921616792 hasConcept C181199279 @default.
• W1921616792 hasConcept C184235292 @default.
• W1921616792 hasConcept C185592680 @default.
• W1921616792 hasConcept C18903297 @default.
• W1921616792 hasConcept C190283241 @default.
• W1921616792 hasConcept C191015642 @default.
• W1921616792 hasConcept C196795494 @default.
• W1921616792 hasConcept C202751555 @default.
• W1921616792 hasConcept C2776200302 @default.
• W1921616792 hasConcept C2776415932 @default.
• W1921616792 hasConcept C2779087070 @default.
• W1921616792 hasConcept C29311851 @default.
• W1921616792 hasConcept C31573885 @default.
• W1921616792 hasConcept C43759708 @default.
• W1921616792 hasConcept C48349386 @default.
• W1921616792 hasConcept C538909803 @default.
• W1921616792 hasConcept C55493867 @default.
• W1921616792 hasConcept C62478195 @default.
• W1921616792 hasConcept C86339819 @default.

• next