Matches in SemOpenAlex for { <https://semopenalex.org/work/W1921655426> ?p ?o ?g. }
- W1921655426 endingPage "1316" @default.
- W1921655426 startingPage "1309" @default.
- W1921655426 abstract "Human phosphate-activated glutaminase (GA) is encoded by two genes: GLS and GLS2. Glioblastomas (GB) usually lack GLS2 transcripts, and their reintroduction inhibits GB growth. The GLS2 gene in peripheral tumors may be i) methylation- controlled and ii) a target of tumor suppressor p53 often mutated in gliomas. Here we assessed the relation of GLS2 downregulation in GB to its methylation and TP53 status. DNA demethylation with 5-aza-2'-deoxycytidine restored GLS2 mRNA and protein content in human GB cell lines with both mutated (T98G) and wild-type (U87MG) p53 and reduced the methylation of CpG1 (promoter region island), and CpG2 (first intron island) in both cell lines. In cell lines and clinical GB samples alike, methylated CpG islands were detected both in the GLS2 promoter (as reported earlier) and in the first intron of this gene. CpG methylation of either island was absent in GLS2-expressing non-tumoros brain tissues. Screening for mutation in the exons 5-8 of TP53 revealed a point mutation in only one out of seven GB examined. In conclusion, aberrant methylation of CpG islands, appear to contribute to silencing of GLS2 in GB by a mechanism bypassing TP53 mutations. © 2015 Wiley Periodicals, Inc." @default.
- W1921655426 created "2016-06-24" @default.
- W1921655426 creator A5019431038 @default.
- W1921655426 creator A5020581447 @default.
- W1921655426 creator A5063700491 @default.
- W1921655426 creator A5074635368 @default.
- W1921655426 creator A5090421438 @default.
- W1921655426 date "2015-08-10" @default.
- W1921655426 modified "2023-10-16" @default.
- W1921655426 title "Downregulation of<i>GLS2</i>in glioblastoma cells is related to DNA hypermethylation but not to the p53 status" @default.
- W1921655426 cites W1898138780 @default.
- W1921655426 cites W1966135244 @default.
- W1921655426 cites W1982993379 @default.
- W1921655426 cites W1986076152 @default.
- W1921655426 cites W1987292751 @default.
- W1921655426 cites W1987744403 @default.
- W1921655426 cites W1994233351 @default.
- W1921655426 cites W1995590577 @default.
- W1921655426 cites W1998424488 @default.
- W1921655426 cites W2001220039 @default.
- W1921655426 cites W2008838621 @default.
- W1921655426 cites W2013592080 @default.
- W1921655426 cites W2027597645 @default.
- W1921655426 cites W2036193202 @default.
- W1921655426 cites W2038652783 @default.
- W1921655426 cites W2042316019 @default.
- W1921655426 cites W2042759566 @default.
- W1921655426 cites W2044418897 @default.
- W1921655426 cites W2044565982 @default.
- W1921655426 cites W2051914071 @default.
- W1921655426 cites W2053907015 @default.
- W1921655426 cites W2056174640 @default.
- W1921655426 cites W2057512766 @default.
- W1921655426 cites W2057546963 @default.
- W1921655426 cites W2069452349 @default.
- W1921655426 cites W2070983419 @default.
- W1921655426 cites W2073641341 @default.
- W1921655426 cites W2074873270 @default.
- W1921655426 cites W2080880778 @default.
- W1921655426 cites W2094812508 @default.
- W1921655426 cites W2095999479 @default.
- W1921655426 cites W2105100844 @default.
- W1921655426 cites W2118151336 @default.
- W1921655426 cites W2128583894 @default.
- W1921655426 cites W2128629321 @default.
- W1921655426 cites W2139122477 @default.
- W1921655426 cites W2148715878 @default.
- W1921655426 cites W2151880414 @default.
- W1921655426 cites W2154920222 @default.
- W1921655426 cites W2155124667 @default.
- W1921655426 cites W2160382843 @default.
- W1921655426 cites W2166138133 @default.
- W1921655426 cites W37732940 @default.
- W1921655426 doi "https://doi.org/10.1002/mc.22372" @default.
- W1921655426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26258493" @default.
- W1921655426 hasPublicationYear "2015" @default.
- W1921655426 type Work @default.
- W1921655426 sameAs 1921655426 @default.
- W1921655426 citedByCount "20" @default.
- W1921655426 countsByYear W19216554262016 @default.
- W1921655426 countsByYear W19216554262017 @default.
- W1921655426 countsByYear W19216554262018 @default.
- W1921655426 countsByYear W19216554262019 @default.
- W1921655426 countsByYear W19216554262020 @default.
- W1921655426 countsByYear W19216554262021 @default.
- W1921655426 countsByYear W19216554262022 @default.
- W1921655426 countsByYear W19216554262023 @default.
- W1921655426 crossrefType "journal-article" @default.
- W1921655426 hasAuthorship W1921655426A5019431038 @default.
- W1921655426 hasAuthorship W1921655426A5020581447 @default.
- W1921655426 hasAuthorship W1921655426A5063700491 @default.
- W1921655426 hasAuthorship W1921655426A5074635368 @default.
- W1921655426 hasAuthorship W1921655426A5090421438 @default.
- W1921655426 hasConcept C104317684 @default.
- W1921655426 hasConcept C119056186 @default.
- W1921655426 hasConcept C127561419 @default.
- W1921655426 hasConcept C140173407 @default.
- W1921655426 hasConcept C150194340 @default.
- W1921655426 hasConcept C153911025 @default.
- W1921655426 hasConcept C189235521 @default.
- W1921655426 hasConcept C190727270 @default.
- W1921655426 hasConcept C33288867 @default.
- W1921655426 hasConcept C502942594 @default.
- W1921655426 hasConcept C54355233 @default.
- W1921655426 hasConcept C81885089 @default.
- W1921655426 hasConcept C86803240 @default.
- W1921655426 hasConceptScore W1921655426C104317684 @default.
- W1921655426 hasConceptScore W1921655426C119056186 @default.
- W1921655426 hasConceptScore W1921655426C127561419 @default.
- W1921655426 hasConceptScore W1921655426C140173407 @default.
- W1921655426 hasConceptScore W1921655426C150194340 @default.
- W1921655426 hasConceptScore W1921655426C153911025 @default.
- W1921655426 hasConceptScore W1921655426C189235521 @default.
- W1921655426 hasConceptScore W1921655426C190727270 @default.
- W1921655426 hasConceptScore W1921655426C33288867 @default.
- W1921655426 hasConceptScore W1921655426C502942594 @default.
- W1921655426 hasConceptScore W1921655426C54355233 @default.
- W1921655426 hasConceptScore W1921655426C81885089 @default.