FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1921710171> ?p ?o ?g. }

• W1921710171 endingPage "1809" @default.
• W1921710171 startingPage "1803" @default.
• W1921710171 abstract "Hypoxia-induced gene expression is initiated when the hypoxia-inducible factor-1 (HIF-1) α subunit is stabilized in response to a lack of oxygen. An HIF-1α-specific prolyl-hydroxylase (PHD) catalyzes hydroxylation of the proline-564 and/or -402 residues of HIF-1α by an oxygen molecule. The hydroxyproline then interacts with the ubiquitin E3 ligase von Hippel Lindau protein and is degraded by an ubiquitin-dependent proteasome. PHD2 is the most active of three PHD isoforms in hydroxylating HIF-1α. Structural analysis showed that the N-terminal region of PHD2 contains a Myeloid translocation protein 8, Nervy, and DEAF1 (MYND)-type zinc finger domain, whereas the catalytic domain is located in its C-terminal region. We found that deletion of the MYND domain increased the activity of both recombinant PHD2 protein and in vitro-translated PHD2. The zinc chelator <i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-tetrakis(2-pyridylmethyl)ethylenediamine augmented the activity of wild-type PHD2-F but not that of PHD2 lacking the MYND domain, confirming that the zinc finger domain is inhibitory. Overexpression of PHD2 lacking the MYND domain caused a greater reduction in the stability and function of HIF-1α than did overexpression of wild-type PHD2, indicating that the MYND domain also inhibits the catalytic activity of PHD2 in vivo." @default.
• W1921710171 created "2016-06-24" @default.
• W1921710171 creator A5008393937 @default.
• W1921710171 creator A5017116763 @default.
• W1921710171 creator A5029297804 @default.
• W1921710171 creator A5030089119 @default.
• W1921710171 creator A5042415165 @default.
• W1921710171 creator A5057451757 @default.
• W1921710171 creator A5060984373 @default.
• W1921710171 creator A5084274452 @default.
• W1921710171 creator A5091510154 @default.
• W1921710171 date "2005-09-09" @default.
• W1921710171 modified "2023-10-10" @default.
• W1921710171 title "Inhibition of the Catalytic Activity of Hypoxia-Inducible Factor-1α-Prolyl-Hydroxylase 2 by a MYND-Type Zinc Finger" @default.
• W1921710171 cites W1749022239 @default.
• W1921710171 cites W1973962332 @default.
• W1921710171 cites W1977461220 @default.
• W1921710171 cites W2005729255 @default.
• W1921710171 cites W2005868568 @default.
• W1921710171 cites W2010689545 @default.
• W1921710171 cites W2016160962 @default.
• W1921710171 cites W2017575850 @default.
• W1921710171 cites W2025974453 @default.
• W1921710171 cites W2031590347 @default.
• W1921710171 cites W2040031153 @default.
• W1921710171 cites W2042216712 @default.
• W1921710171 cites W2044030331 @default.
• W1921710171 cites W2049346572 @default.
• W1921710171 cites W2059566143 @default.
• W1921710171 cites W2075054245 @default.
• W1921710171 cites W2086812941 @default.
• W1921710171 cites W2094881141 @default.
• W1921710171 cites W2096996870 @default.
• W1921710171 cites W2125724189 @default.
• W1921710171 cites W2127562514 @default.
• W1921710171 cites W2129873928 @default.
• W1921710171 cites W2142210400 @default.
• W1921710171 cites W2144625075 @default.
• W1921710171 cites W2145610465 @default.
• W1921710171 cites W2147718842 @default.
• W1921710171 cites W2152823907 @default.
• W1921710171 cites W2161131510 @default.
• W1921710171 cites W2318784916 @default.
• W1921710171 cites W2596045242 @default.
• W1921710171 doi "https://doi.org/10.1124/mol.105.015271" @default.
• W1921710171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16155211" @default.
• W1921710171 hasPublicationYear "2005" @default.
• W1921710171 type Work @default.
• W1921710171 sameAs 1921710171 @default.
• W1921710171 citedByCount "48" @default.
• W1921710171 countsByYear W19217101712012 @default.
• W1921710171 countsByYear W19217101712013 @default.
• W1921710171 countsByYear W19217101712014 @default.
• W1921710171 countsByYear W19217101712015 @default.
• W1921710171 countsByYear W19217101712016 @default.
• W1921710171 countsByYear W19217101712018 @default.
• W1921710171 countsByYear W19217101712019 @default.
• W1921710171 crossrefType "journal-article" @default.
• W1921710171 hasAuthorship W1921710171A5008393937 @default.
• W1921710171 hasAuthorship W1921710171A5017116763 @default.
• W1921710171 hasAuthorship W1921710171A5029297804 @default.
• W1921710171 hasAuthorship W1921710171A5030089119 @default.
• W1921710171 hasAuthorship W1921710171A5042415165 @default.
• W1921710171 hasAuthorship W1921710171A5057451757 @default.
• W1921710171 hasAuthorship W1921710171A5060984373 @default.
• W1921710171 hasAuthorship W1921710171A5084274452 @default.
• W1921710171 hasAuthorship W1921710171A5091510154 @default.
• W1921710171 hasConcept C104292427 @default.
• W1921710171 hasConcept C104317684 @default.
• W1921710171 hasConcept C134459356 @default.
• W1921710171 hasConcept C143065580 @default.
• W1921710171 hasConcept C153911025 @default.
• W1921710171 hasConcept C181199279 @default.
• W1921710171 hasConcept C185592680 @default.
• W1921710171 hasConcept C186055190 @default.
• W1921710171 hasConcept C190062978 @default.
• W1921710171 hasConcept C207583985 @default.
• W1921710171 hasConcept C24284526 @default.
• W1921710171 hasConcept C25602115 @default.
• W1921710171 hasConcept C2780114586 @default.
• W1921710171 hasConcept C2781109383 @default.
• W1921710171 hasConcept C54757728 @default.
• W1921710171 hasConcept C55493867 @default.
• W1921710171 hasConcept C86339819 @default.
• W1921710171 hasConcept C86803240 @default.
• W1921710171 hasConceptScore W1921710171C104292427 @default.
• W1921710171 hasConceptScore W1921710171C104317684 @default.
• W1921710171 hasConceptScore W1921710171C134459356 @default.
• W1921710171 hasConceptScore W1921710171C143065580 @default.
• W1921710171 hasConceptScore W1921710171C153911025 @default.
• W1921710171 hasConceptScore W1921710171C181199279 @default.
• W1921710171 hasConceptScore W1921710171C185592680 @default.
• W1921710171 hasConceptScore W1921710171C186055190 @default.
• W1921710171 hasConceptScore W1921710171C190062978 @default.
• W1921710171 hasConceptScore W1921710171C207583985 @default.
• W1921710171 hasConceptScore W1921710171C24284526 @default.
• W1921710171 hasConceptScore W1921710171C25602115 @default.
• W1921710171 hasConceptScore W1921710171C2780114586 @default.

• next