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• W1921796284 endingPage "2729" @default.
• W1921796284 startingPage "2721" @default.
• W1921796284 abstract "Invariant NKT (iNKT) cells are a unique subset of T lymphocytes that rapidly carry out effector functions following activation with glycolipid Ags, such as the model Ag alpha-galactosylceramide. Numerous studies have investigated the mechanisms leading to Th1 and Th2 cytokine production by iNKT cells, as well as the effects of the copious amounts of cytokines these cells produce. Less is known, however, about the mechanisms of iNKT cell cytotoxicity. In this study, we investigated the effect of Ag availability and strength, as well as the molecules involved in iNKT cytotoxicity. We demonstrate that the iNKT cell cytotoxicity in vivo correlates directly with the amount of CD1d expressed by the targets as well as the TCR affinity for the target glycolipid Ag. iNKT cells from spleen, liver, and thymus were comparable in their cytotoxicity in vitro. Surprisingly, we show that the Ag-specific cytotoxicity of iNKT cells in vivo depended almost exclusively on the interaction of CD95 (Fas) with CD178 (FasL), and that this mechanism can be efficiently used for tumor protection. Therefore, unlike NK cells, which rely mostly on perforin/granzyme-mediated mechanisms, the Ag-specific cytotoxicity of iNKT cells in vivo is largely restricted to the CD95/CD178 pathway." @default.
• W1921796284 created "2016-06-24" @default.
• W1921796284 creator A5019000846 @default.
• W1921796284 creator A5023137852 @default.
• W1921796284 creator A5049796940 @default.
• W1921796284 creator A5059140393 @default.
• W1921796284 date "2010-09-01" @default.
• W1921796284 modified "2023-10-16" @default.
• W1921796284 title "Antigen-Specific Cytotoxicity by Invariant NKT Cells In Vivo Is CD95/CD178-Dependent and Is Correlated with Antigenic Potency" @default.
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• W1921796284 doi "https://doi.org/10.4049/jimmunol.1001018" @default.
• W1921796284 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2989418" @default.
• W1921796284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20660713" @default.
• W1921796284 hasPublicationYear "2010" @default.
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